Bielefeld University

About: Bielefeld University is a education organization based out in Bielefeld, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 10123 authors who have published 26576 publications receiving 728250 citations. The organization is also known as: University of Bielefeld & UNIVERSITAET BIELEFELD.

Stochastic potential and quantum decoherence of heavy quarkonium in the quark-gluon plasma

Abstract: We propose an open quantum systems approach to the physics of heavy quarkonia in a thermal medium, based on stochastic quantum evolution This description emphasizes the importance of collisions with the environment and focuses on the concept of spatial decoherence of the heavy quarkonium wave function It is shown how to determine the parameters of the dynamical evolution, ie the real potential and the noise strength, from a comparison with quantities to be obtained from lattice QCD Furthermore the imaginary part of the lattice QCD heavy quark potential is found to be naturally related to the strength of the noise correlations We discuss the time evolution of Q Q analytically in a limiting scenario for the spatial decoherence and provide a qualitative 1-dimensional numerical simulation of the real-time dynamics PACS numbers:

Use of a novel collagen matrix with oriented pore structure for muscle cell differentiation in cell culture and in grafts

Abstract: Tissue engineering of skeletal muscle from cultured cells has been attempted using a variety of synthetic and natural macromolecular scaffolds. Our study describes the application of artificial scaffolds (collagen sponges, CS) consisting of collagen-I with parallel pores (width 20–50 μm) using the permanent myogenic cell line C2C12. CS were infiltrated with a high-density cell suspension, incubated in medium for proliferation of myoblasts prior to further culture in fusion medium to induce differentiation and formation of multinucleated myotubes. This resulted in a parallel arrangement of myotubes within the pore structures. CS with either proliferating cells or with myotubes were grafted into the beds of excised anterior tibial muscles of immunodeficient host mice. The recipient mice were transgenic for enhanced green fluorescent protein (eGFP) to determine a host contribution to the regenerated muscle tissue. Histological analysis 14–50 days after surgery showed that donor muscle fibres had formed in situ with host contributions in the outer portions of the regenerates. The function of the regenerates was assessed by direct electrical stimulation which resulted in the generation of mechanical force. Our study demonstrated that biodegradable CS with parallel pores support the formation of oriented muscle fibres and are compatible with force generation in regenerated muscle.

Slow-roll inflation with a Gauss-Bonnet correction

Abstract: We consider slow-roll inflation for a single scalar field with an arbitrary potential and an arbitrary nonminimal coupling to the Gauss-Bonnet term. By introducing a combined hierarchy of Hubble and Gauss-Bonnet flow functions, we analytically derive the power spectra of scalar and tensor perturbations. The standard consistency relation between the tensor-to-scalar ratio and the spectral index of tensor perturbations is broken. We apply this formalism to a specific model with a monomial potential and an inverse monomial Gauss-Bonnet coupling and constrain it by the 7-year Wilkinson Microwave Anisotropy Probe data. The Gauss-Bonnet term with a positive (or negative) coupling may lead to a reduction (or enhancement) of the tensor-to-scalar ratio and hence may revive the quartic potential ruled out by recent cosmological data.

Bacterial community shift in treated periodontitis patients revealed by ion torrent 16S rRNA gene amplicon sequencing.

Abstract: Periodontitis, one of the most common diseases in the world, is caused by a mixture of pathogenic bacteria and inflammatory host responses and often treated by antimicrobials as an adjunct to scaling and root planing (SRP). Our study aims to elucidate explorative and descriptive temporal shifts in bacterial communities between patients treated by SRP alone versus SRP plus antibiotics. This is the first metagenomic study using an Ion Torrent Personal Genome Machine (PGM). Eight subgingival plaque samples from four patients with chronic periodontitis, taken before and two months after intervention were analyzed. Amplicons from the V6 hypervariable region of the 16S rRNA gene were generated and sequenced each on a 314 chip. Sequencing reads were clustered into operational taxonomic units (OTUs, 3% distance), described by community metrics, and taxonomically classified. Reads ranging from 599,933 to 650,416 per sample were clustered into 1,648 to 2,659 non-singleton OTUs, respectively. Increased diversity (Shannon and Simpson) in all samples after therapy was observed regardless of the treatment type whereas richness (ACE) showed no correlation. Taxonomic analysis revealed different microbial shifts between both therapy approaches at all taxonomic levels. Most remarkably, the genera Porphyromonas, Tannerella, Treponema, and Filifactor all harboring periodontal pathogenic species were removed almost only in the group treated with SPR and antibiotics. For the species T. forsythia and P. gingivalis results were corroborated by real-time PCR analysis. In the future, hypothesis free metagenomic analysis could be the key in understanding polymicrobial diseases and be used for therapy monitoring. Therefore, as read length continues to increase and cost to decrease, rapid benchtop sequencers like the PGM might finally be used in routine diagnostic.