Institution
Bielefeld University
Education•Bielefeld, Nordrhein-Westfalen, Germany•
About: Bielefeld University is a education organization based out in Bielefeld, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Quantum chromodynamics. The organization has 10123 authors who have published 26576 publications receiving 728250 citations. The organization is also known as: University of Bielefeld & UNIVERSITAET BIELEFELD.
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TL;DR: In this article, several discrete molecular transition metal and lanthanide-containing polyoxo-tungstates and -molybdates with a focus on their magnetic properties are reported.
491 citations
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TL;DR: Two phylotypes of the candidate genus ‘Entotheonella’ with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei.
Abstract: Cultivated bacteria such as actinomycetes are a highly useful source of biomedically important natural products. However, such ‘talented’ producers represent only a minute fraction of the entire, mostly uncultivated, prokaryotic diversity. The uncultured majority is generally perceived as a large, untapped resource of new drug candidates, but so far it is unknown whether taxa containing talented bacteria indeed exist. Here we report the single-cell- and metagenomics-based discovery of such producers. Two phylotypes of the candidate genus ‘Entotheonella’ with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei. Almost all bioactive polyketides and peptides known from this animal were attributed to a single phylotype. ‘Entotheonella’ spp. are widely distributed in sponges and belong to an environmental taxon proposed here as candidate phylum ‘Tectomicrobia’. The pronounced bioactivities and chemical uniqueness of ‘Entotheonella’ compounds provide significant opportunities for ecological studies and drug discovery.
490 citations
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TL;DR: In this article, a comprehensive chemical kinetic model for all the four isomers of butanol (e.g., 1-, 2-, iso- and tert-butanol) is presented.
489 citations
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TL;DR: The Eating Disorder Examination-Questionnaire (EDE-Q) as discussed by the authors is a variant of the EDE-Q, which is used by Fairburn and Beglin to diagnose eating disorders.
Abstract: Zusammenfassung. Der Eating Disorder Examination-Questionnaire von Fairburn und Beglin (EDE-Q; 1994) ist die Fragebogenversion des strukturierten Essstorungsinterviews Eating Disorder Examination (EDE). Der EDE-Q erfasst die spezifische Essstorungspsychopathologie mithilfe von vier Subskalen zum gezugelten Essverhalten, zu Sorgen uber das Essen, Gewicht und Figur. Die in diesem Beitrag vorgestellte deutschsprachige Ubersetzung des EDE-Q wurde in Stichproben mit Anorexia nervosa, Bulimia nervosa und atypischen Essstorungen, sowie nicht-klinischen, subklinischen und psychiatrischen Vergleichsgruppen teststatistisch untersucht (N = 706). Der EDE-Q erwies sich als intern konsistent und stabil. Seine faktorielle Struktur wurde teilweise reproduziert. Die Kennwerte des EDE-Q waren signifikant mit denen des EDE korreliert, fielen erwartungsgemas jedoch teilweise hoher aus. Weitere Hinweise fur die konvergente Validitat ergaben sich durch Korrelationen mit konzeptverwandten Fragebogen. Der EDE-Q zeigte eine gute ...
488 citations
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TL;DR: A reference genome sequence for sugar beet is presented as the first non-rosid, non-asterid eudicot genome, advancing comparative genomics and phylogenetic reconstructions and provides evidence for the separation of Caryophyllales before the split of asterids and rosids, and revealed lineage-specific gene family expansions and losses.
Abstract: Sugar beet (Beta vulgaris ssp. vulgaris) is an important crop of temperate climates which provides nearly 30% of the world's annual sugar production and is a source for bioethanol and animal feed. The species belongs to the order of Caryophylalles, is diploid with 2n = 18 chromosomes, has an estimated genome size of 714-758 megabases and shares an ancient genome triplication with other eudicot plants. Leafy beets have been cultivated since Roman times, but sugar beet is one of the most recently domesticated crops. It arose in the late eighteenth century when lines accumulating sugar in the storage root were selected from crosses made with chard and fodder beet. Here we present a reference genome sequence for sugar beet as the first non-rosid, non-asterid eudicot genome, advancing comparative genomics and phylogenetic reconstructions. The genome sequence comprises 567 megabases, of which 85% could be assigned to chromosomes. The assembly covers a large proportion of the repetitive sequence content that was estimated to be 63%. We predicted 27,421 protein-coding genes supported by transcript data and annotated them on the basis of sequence homology. Phylogenetic analyses provided evidence for the separation of Caryophyllales before the split of asterids and rosids, and revealed lineage-specific gene family expansions and losses. We sequenced spinach (Spinacia oleracea), another Caryophyllales species, and validated features that separate this clade from rosids and asterids. Intraspecific genomic variation was analysed based on the genome sequences of sea beet (Beta vulgaris ssp. maritima; progenitor of all beet crops) and four additional sugar beet accessions. We identified seven million variant positions in the reference genome, and also large regions of low variability, indicating artificial selection. The sugar beet genome sequence enables the identification of genes affecting agronomically relevant traits, supports molecular breeding and maximizes the plant's potential in energy biotechnology.
485 citations
Authors
Showing all 10375 results
Name | H-index | Papers | Citations |
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Stefan Grimme | 113 | 680 | 105087 |
Alfred Pühler | 102 | 658 | 45871 |
James Barber | 102 | 642 | 42397 |
Swagata Mukherjee | 101 | 1048 | 46234 |
Hans-Joachim Werner | 98 | 317 | 48508 |
Krzysztof Redlich | 98 | 609 | 32693 |
Graham C. Walker | 93 | 381 | 36875 |
Christian Meyer | 93 | 1081 | 38149 |
Muhammad Farooq | 92 | 1341 | 37533 |
Jean Willy Andre Cleymans | 90 | 542 | 27685 |
Bernhard T. Baune | 90 | 608 | 50706 |
Martin Wikelski | 89 | 420 | 25821 |
Niklas Luhmann | 85 | 421 | 42743 |
Achim Müller | 85 | 926 | 35874 |
Oliver T. Wolf | 83 | 337 | 24211 |