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Institution

Boise State University

EducationBoise, Idaho, United States
About: Boise State University is a education organization based out in Boise, Idaho, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 3698 authors who have published 8664 publications receiving 210163 citations. The organization is also known as: BSU & Boise State.


Papers
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Journal ArticleDOI
TL;DR: Self-assemble an aptamer-based nanoscaffold that contains separate cell-targeting and photo-regulated drug-carrying domains, realizing multiple therapeutic functionalities in a single construct.
Abstract: Platforms for targeted drug-delivery must simultaneously exhibit serum stability, efficient directed cell internalization, and triggered drug release. Here, using lipid-mediated self-assembly of aptamers, we combine multiple structural motifs into a single nanoconstruct that targets hepatocyte growth factor receptor (cMet). The nanocarrier consists of lipidated versions of a cMet-binding aptamer and a separate lipidated GC-rich DNA hairpin motif loaded with intercalated doxorubicin. Multiple 2',6'-dimethylazobenzene moieties are incorporated into the doxorubicin-binding motif to trigger the release of the chemotherapeutics by photoisomerization. The lipidated DNA scaffolds self-assemble into spherical hybrid-nanoconstructs that specifically bind cMet. The combined features of the nanocarriers increase serum nuclease resistance, favor their import into cells presumably mediated by endocytosis, and allow selective photo-release of the chemotherapeutic into the targeted cells. cMet-expressing H1838 tumor cells specifically internalize drug-loaded nanoconstructs, and subsequent UV exposure enhances cell mortality. This modular approach thus paves the way for novel classes of powerful aptamer-based therapeutics.

58 citations

Journal ArticleDOI
TL;DR: On average and for both generations, economic pressure predicted relative increases in couples' hostile, contemptuous, and angry behaviors; however, couples who were highly effective problem solvers experienced no increases in these behaviors in response to economic pressure.
Abstract: Research suggests that economic stress disrupts perceived romantic relationship quality; yet less is known regarding the direct influence of economic stress on negative behavioral exchanges between partners over time. Another intriguing question concerns the degree to which effective problem-solving might protect against this hypothesized association. To address these issues, the authors studied two generations of couples who were assessed approximately 13 years apart (Generation 1: N = 367, Generation 2: N = 311). On average and for both generations, economic pressure predicted relative increases in couples' hostile, contemptuous, and angry behaviors; however, couples who were highly effective problem solvers experienced no increases in these behaviors in response to economic pressure. Less effective problem solvers experienced the steepest increases in hostile behaviors in response to economic pressure. Because these predictive pathways were replicated in both generations of couples it appears that these stress and resilience processes unfold over time and across generations.

58 citations

Journal ArticleDOI
TL;DR: This work considers the design of identical one-bit probabilistic quantizers for distributed estimation in sensor networks and forms an optimization problem to obtain the optimum minimax-CRB quantizer, which demonstrates the superior performance of the new quantizer-particularly in the moderate to high-SNR regime.
Abstract: We consider the design of identical one-bit probabilistic quantizers for distributed estimation in sensor networks. We assume the parameter-range to be finite and known and use the maximum Cramer-Rao lower bound (CRB) over the parameter-range as our performance metric. We restrict our theoretical analysis to the class of antisymmetric quantizers and determine a set of conditions for which the probabilistic quantizer function is greatly simplified. We identify a broad class of noise distributions, which includes Gaussian noise in the low-SNR regime, for which the often used threshold-quantizer is found to be minimax-optimal. Aided with theoretical results, we formulate an optimization problem to obtain the optimum minimax-CRB quantizer. For a wide range of noise distributions, we demonstrate the superior performance of the new quantizer-particularly in the moderate to high-SNR regime.

58 citations

Journal ArticleDOI
TL;DR: Several causes of zero-flow gage readings are described: frozen surface water, flow reversals, instrument error, and natural or human-driven upstream source losses or bypass flow and their implications for reach- and watershed-scale dynamics are described.
Abstract: Streamflow observations can be used to understand, predict, and contextualize hydrologic, ecological, and biogeochemical processes and conditions in streams. Stream gages are point measurements along rivers where streamflow is measured, and are often used to infer upstream watershed-scale processes. When stream gages read zero, this may indicate that the stream has fully dried; however, zero-flow readings can also be caused by a wide range of other factors. Our ability to identify whether or not a zero-flow gage reading indicates a dry fluvial system has far reaching environmental implications. Incorrect identification and interpretation by the data user can lead to hydrologic, ecological, and/or biogeochemical predictions from models and analyses. Here, we describe several causes of zero-flow gage readings: frozen surface water, flow reversals, instrument error, and natural or human-driven upstream source losses or bypass flow. For these examples, we discuss the implications of zero-flow interpretations. We also highlight additional methodss for determining flow presence, including direct observations, statistical methods, and hydrologic models, which can be applied to interpret causes of zero-flow gage readings and implications for reach- and watershed-scale dynamics. Such efforts are necessary to improve our ability to understand and predict surface flow activation, cessation, and connectivity across river networks. Developing this integrated understanding of the wide range of possible meanings of zero-flows will only attain greater importance in a more variable and changing hydrologic climate.

58 citations

Journal ArticleDOI
TL;DR: An examination of research relevant to this hypothesis suggests that there are a variety of cognitive and affective processes that may produce a relatively condoning attitude toward perpetrators as a result of explaining their actions.
Abstract: Analysts of evil and violence express the concern that to explain harmdoing may result in a condoning attitude toward perpetrators. An examination of research relevant to this hypothesis suggests that there are a variety of cognitive and affective processes that may produce a relatively condoning attitude toward perpetrators as a result of explaining their actions. Evidence from 3 exploratory studies supported the exonerating effects of explanations. Participants generating explicit explanations of harmdoing displayed a more condoning attitude toward pelpetrators than did those forming impressions of perpetrators without first explaining the acts. Participants reading social-psychological explanations of harmdoing also judged the researcher to be more condoning of perpetrators than those reading dispositional explanations of the same behavior. Implications of these findings are discussed.

58 citations


Authors

Showing all 3902 results

NameH-indexPapersCitations
Jeffrey G. Andrews11056263334
Zhu Han109140748725
Brian R. Flay8932526390
Jeffrey W. Elam8343524543
Pramod K. Varshney7989430834
Scott Fendorf7924421035
Gregory F. Ball7634221193
Yan Wang72125330710
David C. Dunand7252719212
Juan Carlos Diaz-Velez6433414252
Michael K. Lindell6218619865
Matthew J. Kohn6216413741
Maged Elkashlan6129414736
Bernard Yurke5824217897
Miguel Ferrer5847811560
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202370
2022210
2021763
2020695
2019620
2018637