Bonn-Rhein-Sieg University of Applied Sciences

About: Bonn-Rhein-Sieg University of Applied Sciences is a education organization based out in Sankt Augustin, Germany. It is known for research contribution in the topics: Bond graph & Gas chromatography. The organization has 507 authors who have published 814 publications receiving 7524 citations.

A strong magnetic field around the supermassive black hole at the centre of the Galaxy

Abstract: Earth's nearest candidate supermassive black hole lies at the centre of the Milky Way Its electromagnetic emission is thought to be powered by radiatively inefficient accretion of gas from its environment, which is a standard mode of energy supply for most galactic nuclei X-ray measurements have already resolved a tenuous hot gas component from which the black hole can be fed The magnetization of the gas, however, which is a crucial parameter determining the structure of the accretion flow, remains unknown Strong magnetic fields can influence the dynamics of accretion, remove angular momentum from the infalling gas, expel matter through relativistic jets and lead to synchrotron emission such as that previously observed Here we report multi-frequency radio measurements of a newly discovered pulsar close to the Galactic Centre and show that the pulsar's unusually large Faraday rotation (the rotation of the plane of polarization of the emission in the presence of an external magnetic field) indicates that there is a dynamically important magnetic field near the black hole If this field is accreted down to the event horizon it provides enough magnetic flux to explain the observed emission-from radio to X-ray wavelengths-from the black hole

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.

Abstract: Triple-negative breast cancer (TNBC) lacks targeted therapies and has a worse prognosis than other breast cancer subtypes, underscoring an urgent need for new therapeutic targets and strategies. IRE1 is an endoplasmic reticulum (ER) stress sensor, whose activation is predominantly linked to the resolution of ER stress and, in the case of severe stress, to cell death. Here we demonstrate that constitutive IRE1 RNase activity contributes to basal production of pro-tumorigenic factors IL-6, IL-8, CXCL1, GM-CSF, and TGFβ2 in TNBC cells. We further show that the chemotherapeutic drug, paclitaxel, enhances IRE1 RNase activity and this contributes to paclitaxel-mediated expansion of tumor-initiating cells. In a xenograft mouse model of TNBC, inhibition of IRE1 RNase activity increases paclitaxel-mediated tumor suppression and delays tumor relapse post therapy. We therefore conclude that inclusion of IRE1 RNase inhibition in therapeutic strategies can enhance the effectiveness of current chemotherapeutics.

Real-time Convolutional Neural Networks for Emotion and Gender Classification

Abstract: In this paper we propose an implement a general convolutional neural network (CNN) building framework for designing real-time CNNs. We validate our models by creating a real-time vision system which accomplishes the tasks of face detection, gender classification and emotion classification simultaneously in one blended step using our proposed CNN architecture. After presenting the details of the training procedure setup we proceed to evaluate on standard benchmark sets. We report accuracies of 96% in the IMDB gender dataset and 66% in the FER-2013 emotion dataset. Along with this we also introduced the very recent real-time enabled guided back-propagation visualization technique. Guided back-propagation uncovers the dynamics of the weight changes and evaluates the learned features. We argue that the careful implementation of modern CNN architectures, the use of the current regularization methods and the visualization of previously hidden features are necessary in order to reduce the gap between slow performances and real-time architectures. Our system has been validated by its deployment on a Care-O-bot 3 robot used during RoboCup@Home competitions. All our code, demos and pre-trained architectures have been released under an open-source license in our public repository.

Mechanisms Underlying the Osteo- and Adipo-Differentiation of Human Mesenchymal Stem Cells

Abstract: Human mesenchymal stem cells (hMSCs) are considered a promising cell source for regenerative medicine, because they have the potential to differentiate into a variety of lineages among which the mesoderm-derived lineages such adipo- or osteogenesis are investigated best. Human MSCs can be harvested in reasonable to large amounts from several parts of the patient's body and due to this possible autologous origin, allorecognition can be avoided. In addition, even in allogenic origin-derived donor cells, hMSCs generate a local immunosuppressive microenvironment, causing only a weak immune reaction. There is an increasing need for bone replacement in patients from all ages, due to a variety of reasons such as a new recreational behavior in young adults or age-related diseases. Adipogenic differentiation is another interesting lineage, because fat tissue is considered to be a major factor triggering atherosclerosis that ultimately leads to cardiovascular diseases, the main cause of death in industrialized countries. However, understanding the differentiation process in detail is obligatory to achieve a tight control of the process for future clinical applications to avoid undesired side effects. In this review, the current findings for adipo- and osteo-differentiation are summarized together with a brief statement on first clinical trials.

Robust 3D-mapping with time-of-flight cameras

Abstract: Time-of-Flight cameras constitute a smart and fast technology for 3D perception but lack in measurement precision and robustness. The authors present a comprehensive approach for 3D environment mapping based on this technology. Imprecision of depth measurements are properly handled by calibration and application of several filters. Robust registration is performed by a novel extension to the Iterative Closest Point algorithm. Remaining registration errors are reduced by global relaxation after loop-closure and surface smoothing. A laboratory ground truth evaluation is provided as well as 3D mapping experiments in a larger indoor environment.