Boston College

About: Boston College is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 9749 authors who have published 25406 publications receiving 1105145 citations. The organization is also known as: BC.

Overreaction, Delayed Reaction, and Contrarian Profits

Abstract: This article examines the contribution of stock price overreaction and delayed reaction to the profitability of contrarian strategies. The evidence indicates that stock prices overreact to firm-specific information, but react with a delay to common factors. Delayed reactions to common factors give rise to a size-related lead-lag effect in stock returns. In sharp contrast with the conclusions in the extant literature, however, this article finds that most of the contrarian profit is due to stock price overreaction and a very small fraction of the profit can be attributed to the lead-lag effect

Development of the Conformity to Feminine Norms Inventory

Abstract: This article describes the construction of the Conformity to Feminine Norms Inventory (CFNI), which was designed to assess women’s conformity to an array of feminine norms found in the dominant culture in the United States. In addition, we present four studies in which the psychometric properties of the CFNI were examined. In Study 1, factor analysis indicated that the CFNI is comprised of eight distinct factors labeled as Nice in Relationships, Thinness, Modesty, Domestic, Care for Children, Romantic Relationship, Sexual Fidelity, and Invest in Appearance. Results from Study 2 indicated that the CFNI has strong internal consistency estimates and differentiates college women from college men. In addition, Study 2 demonstrated that the CFNI Total score and subscale scores relate to Bem Sex Role Inventory and Feminist Identity Development Scale scores in theoretically consistent patterns. Study 3 indicated that the CFNI Total score and several of the subscales significantly and positively relate to scores on the Eating Disorder Inventory. Finally, Study 4 demonstrated that the CFNI Total score and subscale scores have high test-retest estimates for a 2–3 week period. The discussion focuses on potential uses of the CFNI, limitations to the study, and suggestions for future research.

Probing the alpha-helical structural stability of stapled p53 peptides: molecular dynamics simulations and analysis.

Abstract: Reactivation of the p53 cell apoptosis pathway through inhibition of the p53-hDM2 interaction is a viable approach to suppress tumor growth in many human cancers and stabilization of the helical structure of synthetic p53 analogs via a hydrocarbon cross-link (staple) has been found to lead to increased potency and inhibition of protein-protein binding (J. Am. Chem. Soc. 129: 5298). However, details of the structure and dynamic stability of the stapled peptides are not well understood. Here, we use extensive all-atom molecular dynamics simulations to study a series of stapled alpha-helical peptides over a range of temperatures in solution. The peptides are found to exhibit substantial variations in predicted alpha-helical propensities that are in good agreement with the experimental observations. In addition, we find significant variation in local structural flexibility of the peptides with the position of the linker, which appears to be more closely related to the observed differences in activity than the absolute alpha-helical stability. These simulations provide new insights into the design of alpha-helical stapled peptides and the development of potent inhibitors of alpha-helical protein-protein interfaces.