Showing papers by "Boston University published in 1991"

Connections: New Ways of Working in the Networked Organization

Abstract: From the Publisher: Computer networking is changing the way people work and the way organizations function. "Connections" is an accessible guide to the promise and the pitfalls of this latest phase of the computer revolution.

Probability of stroke: a risk profile from the Framingham Study.

Abstract: A health risk appraisal function has been developed for the prediction of stroke using the Framingham Study cohort. The stroke risk factors included in the profile are age, systolic blood pressure, the use of antihypertensive therapy, diabetes mellitus, cigarette smoking, prior cardiovascular disease (coronary heart disease, cardiac failure, or intermittent claudication), atrial fibrillation, and left ventricular hypertrophy by electrocardiogram. Based on 472 stroke events occurring during 10 years' follow-up from biennial examinations 9 and 14, stroke probabilities were computed using the Cox proportional hazards model for each sex based on a point system. On the basis of the risk factors in the profile, which can be readily determined on routine physical examination in a physician's office, stroke risk can be estimated. An individual's risk can be related to the average risk of stroke for persons of the same age and sex. The information that one's risk of stroke is several times higher than average may provide the impetus for risk factor modification. It may also help to identify persons at substantially increased stroke risk resulting from borderline levels of multiple risk factors such as those with mild or borderline hypertension and facilitate multifactorial risk factor modification.

Lower Class Culture As a Generating Milieu of Gang Delinquency

Abstract: The etiology of delinquency has long been a controversial issue, and is particularly so at present. The bulk of the substantive data on which the following material is based was collected in connection with a service-research project in the control of gang delinquency. The major sets of etiological factors adduced to explain delinquency are, in simplified terms, the physiological, the psychodynamic, and the environmental. In the case of "gang" delinquency, the cultural system which exerts the most direct influence on behavior is that of the lower class community itself—a long-established, distinctively patterned tradition with integrity of its own—rather than a so-called "delinquent subculture". The dominant concern over "trouble" involves a distinction of critical importance for the lower class community—that between "law-abiding" and "non-law-abiding" behavior. The one-sex peer group is a highly prevalent and significant structural form in the lower class community.

Learning from Samples of One or Fewer

Abstract: Organizations learn from experience. Sometimes, however, history is not generous with experience. We explore how organizations convert infrequent events into interpretations of history, and how they balance the need to achieve agreement on interpretations with the need to interpret history correctly. We ask what methods are used, what problems are involved, and what improvements might be made. Although the methods we observe are not guaranteed to lead to consistent agreement on interpretations, valid knowledge, improved organizational performance, or organizational survival, they provide possible insights into the possibilities for and problems of learning from fragments of history.

Switching Cognitive Gears: From Habits of Mind to Active Thinking

Abstract: The phrase "switching cognitive gears" is used to call attention to the fact that cognitive functioning involves the capacity to shift between cognitive modes, from automatic processing to conscious engagement and back again. Effectiveness may be as much a function of an actor's capacity to sense when a switch is appropriate, as to process in one or another mode. In this paper the authors develop a perspective on the switch from automatic to active thinking and the conditions that provoke it. They apply the perspective to work settings and identify types of situations in which actors are expected to switch from habits of mind to active thinking. They propose further work to develop a framework for understanding the switch from active thinking to automatic.

Checking computations in polylogarithmic time

Abstract: Motivated by Manuel Blum’s concept of inst ante checking, we consider new, very fast and generic mechanisms of checking computations. Our results exploit recent advances in interactive proof protocols [LFKN], [Sh], and especially the MIP = NEXP protocol from [BFL]. WJe show that every nondeterministic computational task S(Z, y), defined as a polynomial time relation between the instance x, representing the input and output combined, and the witness y can be modified to a task S such that: (i) the same instances remain accepted; (ii) each instance/witness pair becomes checkable in poly!ogariihmic Monte Carlo time; and (iii) a witness satisfying S’ can be computed in polynomial time from a witness satisfying S. Here the instance and the description of S have to be provided in error-correcting code (since the checker will not notice slight changes). A modification of the MIP proof was required to achieve polynomial time in (iii); the earlier technique yields N“(*OglOg’1 time only. This result becomes significant if software and hardware reliability are regarded aa a considerable cost factor. The polylogarithmic checker is the only part of the system that needs to be trusted; it can be hard wired. (We use just one Checker for all problems!) The checker is tiny and so presumably can be optimized and checked off-line at a modest cost. In this setup, a single reliable PC can monitor the operation of a herd of supercomputers working with possibly extremely powerful but unreliable software and untested hardware. 1Research partially supported by NSF Grant CCR-871OO78. Email: laci@cs.uchicago. edu 2Rese~& partiay supported by NSF Grant CCR-SMXI$XEK5. E-mail: fortnow@cs.uc&cago. edu 3Supported by NSF grant CCR-SJC115276. E-mail: Lnd@cs.bu.edu 4111 cummington St., Boston MA 02215. 5E-mail: mario@cs.uchicago .edu ~1100 E 58th St, Chicago IL 60637. Permission to copy without fee all or part of this msterisl is granted provided that tie copies are not made or distributed for direct commercial advantage, the ACM copyright notice and the title of the publication and its date appear, and notice is given that copying is by permission of the Association for Computing Machinery. To copy otherwise, or to republish, requires a fee snd/or specific permission. @ 1991 ACM 089791-397-31911000410021 $1.50 Leonid A. Levin 3

A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer

Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and tumor growth in the rodent colon. We assessed NSAID use in relation to risk of human large-bowel cancer in a hospital-based, case-control study of 1326 patients with colorectal cancer and 4891 control patients. For regular NSAID use that continued into the year before interview, the multivariate relative risk estimate was 0.5 (95% confidence interval, 0.4 to 0.8); the estimate decreased as the duration of use increased, but the trend was not statistically significant. Similar results were obtained whether cancer or non-cancer controls were used, and the inverse association was apparent for both colon cancer and rectal cancer in men and women and in subjects younger and older than 60 years. Regular NSAID use that had been discontinued at least 1 year previously and non-regular use were not associated with risk. Almost all regular NSAID use was of aspirin-containing drugs. The present data suggest that the sustained use of NSAIDs reduces the incidence of human large-bowel cancer.

Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.

Abstract: The N-methyl-D-aspartate (NMDA) receptor is believed to play a major role in learning and in excitotoxic neuronal damage associated with stroke and epilepsy. Pregnenolone sulfate, a neurosteroid, specifically enhances NMDA-gated currents in spinal cord neurons, while inhibiting receptors for the inhibitory amino acids glycine and gamma-aminobutyric acid, as well as non-NMDA glutamate receptors. This observation is consistent with the hypothesis that neurosteroids such as pregnenolone sulfate are involved in regulating the balance between excitation and inhibition in the central nervous system.

Cerebral amyloid angiopathy without and with cerebral hemorrhages: a comparative histological study.

Abstract: To identify those factors associated with cerebral hemorrhage among brains with cerebral amyloid angiopathy (CAA), we undertook a comparative postmortem histopathological study of amyloid-containing vessels in the brains of patients with and without hemorrhage. Those without hemorrhage were represented by the following two groups: (1) elderly patients from a large general hospital (n = 66; age range, 75–107 years) and (2) patients with various neuropsychiatric disorders (n = 70; age range, 27–96 years). CAA was found in 45% of thefirst group and in 54% of the second group. The findings in these patients were compared with those in 17 brains in which both CAA and cerebral hemorrhage were present. We found that CAA was more severe in the brains with cerebral hemorrhage than in those without, and that fibrinoid necrosis was seen only in the brains with cerebral hemorrhage (12 of the 17 brains). Microaneurysms occurred only in the presence of severe, rather than moderate or mild, CAA. Serial sections in 2 brains of patients with cerebral hemorrhage showed fibrinoid necrosis, microaneurysms, and vascular rupture in close association with the hemorrhage. In 2 patients, hemorrhage was precipitated by trauma, and in 1, it was secondary to metastatic carcinoma. The features of brains from patients with CAA that are most consistently related to cerebral hemorrhage are (1) a severe degree of CAA and (2) the presence of fibrinoid necrosis, with or without microaneurysms.

A genetic study of male sexual orientation.

Abstract: Homosexual male probands with monozygotic cotwins, dizygotic cotwins, or adoptive brothers were recruited using homophile publications. Sexual orientation of relatives was assessed either by asking relatives directly, or when this was impossible, asking the probands. Of the relatives whose sexual orientation could be rated, 52% (29/56) of monozygotic cotwins, 22% (12/54) of dizygotic cotwins, and 11% (6/57) of adoptive brothers were homosexual. Heritabilities were substantial under a wide range of assumptions about the population base rate of homosexuality and ascertainment bias. However, the rate of homosexuality among nontwin biological siblings, as reported by probands, 9.2% (13/142), was significantly lower than would be predicted by a simple genetic hypothesis and other published reports. A proband's self-reported history of childhood gender non-conformity did not predict homosexuality in relatives in any of the three subsamples. Thus, childhood gender nonconformity does not appear to be an indicator of genetic loading for homosexuality. Cotwins from concordant monozygotic pairs were very similar for childhood gender nonconformity.

The constituent equations of piezoelectric heterogeneous bimorphs

Abstract: The electromechanical characteristics of a heterogeneous piezoelectric bender subjected to various electrical and mechanical boundary conditions are discussed based on the results of the free bender analysis. The mechanical boundary conditions considered are: a mechanical moment at the end of the bender, a force applied perpendicularly to the tip of the bender, and a uniform load applied over the entire length of the bender. The constituent equations of the bender under these electromechanical influences are derived by calculating the internal energy assuming thermodynamic equilibrium. >

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

Abstract: A possible relationship between protein kinase C activation and impaired receptor-mediated endothelium-dependent relaxation in diabetes mellitus was examined in isolated aorta from normal rabbit exposed to elevated glucose. Aorta treated for 10 min with 4-phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, showed decreased relaxations to the endothelium-dependent vasodilator, acetylcholine, similar to normal aorta exposed to elevated glucose (22 and 44 mM) for 6 h. Relaxations to the receptor-independent endothelium-dependent vasodilator, A23187, and those caused by the direct smooth muscle vasodilator, sodium nitroprusside, were unaffected by treatment with PMA or exposure to elevated glucose. Indomethacin increased relaxations to acetylcholine of aorta treated with PMA indicating a role for vasoconstrictor prostanoids. PMA caused a significant increase in basal and acetylcholine-stimulated release of vasoconstrictor prostanoids including thromboxane A2 from aortic segments with, but not without endothelium. Protein kinase C inhibitors, H-7 or sphingosine, restored the abnormal acetylcholine-induced relaxations as well as suppressed the abnormal release of prostanoids in aorta exposed to elevated glucose. These findings suggest that the dysfunction of receptor-mediated endothelium-dependent relaxation associated with exposure to elevated glucose is due to increased production of vasoconstrictor prostanoids by the endothelium as a consequence of protein kinase C activation.

Multiple pulse interactions and averaging in systems of coupled neural oscillators

Abstract: Oscillators coupled strongly are capable of complicated behavior which may be pathological for biological control systems. Nevertheless, strong coupling may be needed to prevent asynchrony. We discuss how some neural networks may be designed to achieve only simple locking behavior when the coupling is strong. The design is based on the fact that the method of averaging produces equations that are capable only of locking or drift, not pathological complexity. Furthermore, it is shown that oscillators that interact by means of multiple pulses per cycle, dispersed around the cycle, behave like averaged equations, even if the number of pulses is small. We discuss the biological intuition behind this scheme, and show numerically that it works when the oscillators are taken to be composites, each unit of which is governed by a well-known model of a neural oscillator. Finally, we describe numerical methods for computing from equations for coupled limit cycle oscillators the averaged coupling functions of our theory.

The constituent equations of piezoelectric bimorphs

Abstract: A brief review of applications of piezoelectric bimorphs is presented. The constituent equations which describe the behavior of piezoelectric bimorphs for various mechanical boundary conditions are derived. The internal energy density of infinitesimally small volume elements in thermodynamic equilibrium is calculated in the presence of a voltage on the electrodes, a clamped cantilever beam condition on one side of the beam and a set of three different classical boundary conditions on the other side of the beam. These are a mechanical moment M at the end of the beam, a force F perpendicular to the beam, applied at its tip, and a uniformly distributed body force p. The total internal energy content is calculated by integrating over the entire volume of the beam. Two different beam configurations are considered: parallel polarizations of the two adjoining elements of the beam with an internal electrode; and antiparallel orientation without an internal electrode. The canonical conjugate of the moment is calculated as the angular deflection at the tip of the beam α, while that of the force at the tip is the local vertical deflection δ. The canonical conjugate of the uniform load on the beam is found to be the volume displacement V of the beam. The canonical conjugate of the voltage across the electrodes is the charge on the electrodes. The equations are given in the direct form, with external parameters (M, V), (F, V), and (p, V) as independent variables and also in a linear combination with (M, F, p, V) as variables. These constituent equations can be used to calculate the behavior of the bimorph under any condition that can be described as a linear combination of forces at the tip, moments at the tip and uniform loads on the entire beam. This allows us to use the bimorph as a black box, without having to consider its internal movement or charges.

The effects of glyceride structure on absorption and metabolism.

Abstract: The subtle effects of the stereochemistry of acyl glycerols are apparent from the cited studies. It is not adequate to simply measure the fatty acid composition of dietary lipids or chylomicrons generated from them. To understand the importance of stereospecific acyl glycerols, simplification of the systems is necessary because of the incredible diversity found among dietary triacylglycerols. By feeding simple analogues corresponding to major triacylglycerols found in oils and fats it should be possible to determine the absorption, uptake into the mucosa, resynthesis into chylomicrons, and the stereospecificity that remains. Hydrolysis and uptake of these defined chylomicron triacylglycerols into adipose tissue or muscle could be followed and stereospecificity again determined in depot fats. Finally, the composition of the remnants, particularly the core and surface, and of the bound apoproteins needs to be related to their plasma residence time, hepatic removal, and deposition in nonhepatic tissues such as spleen, bone marrow, and arterial intima. Since increased serum cholesterol and atherogenicity in animals have been related to different dietary fats, some of the effects noted here, that is the retention of certain kinds of remnants in plasma, may lead to increased serum cholesterol and atherogenesis. We must study the metabolism of a few key stereospecific triacylglycerols in more detail to increase our understanding of their effects on hypercholesterolemia and atherogenesis.

Aging and immune function

Abstract: Since it is too difficult to study aging of the organism as a whole, most investigators try to focus on a specific physiological system that exhibits age-dependent functional changes, in the hopes that elucidation (in biochemical and developmental terms) of the mechanism of senescent change will provide insight into the aging process itself. The immune system is among the most maleable of such models, in that well-defined cell types will produce well-defined molecules with predictable functions in vitro and in vivo. The increasing power of basic immunological science should, in the next decade, permit an increasingly fine appreciation of how aging leads to immune decline. This expanding conceptual framework will then suggest new ideas about the role of immunosenescence in degenerative, infectious, and neoplastic illnesses and may also generate increasingly rational strategies for therapeutic intervention.

Reduced Cerebral Grey Matter Observed in Alcoholics Using Magnetic Resonance Imaging

Abstract: Twenty-eight chronic alcoholics and 36 age- and sex-matched non-alcoholic controls were examined with magnetic resonance imaging and brain morphometric analyses. Results confirmed large increases in subarachnoid cerebrospinal fluid (CSF) volume and mild ventricular enlargement in the alcoholics and revealed associated volume reductions of localized cortical and subcortical cerebral structures. Volume losses in the diencephalon, the caudate nucleus, dorsolateral frontal and parietal cortex, and mesial temporal lobe structures were the most prominent. Significant correlations between increments in cortical and ventricular CSF and decrements in the volume of cortical and subcortical grey matter were noted. Although there was little evidence for relationships between performance on neuropsychological tests and volume of grey matter structures, significant correlations between some cognitive measures and subcortical and cortical fluid volumes were found. The parallels between this pattern of affected structures and recent neuropathological findings are discussed.

Plantar fasciitis. Etiology, treatment, surgical results, and review of the literature.

Abstract: Plantar fasciitis is a common orthopedic syndrome among athletes and nonathletes. The etiology of the pain is multifactorial but usually involves inflammation and degeneration of the plantar fascia origin. The majority of patients will respond to conservative measures. Surgical treatment is reserved for those patients who do not respond. A complete plantar fascia release is performed through a medial longitudinal incision. Prominent heel spurs and degenerated areas in the plantar fascia are resected. Of 27 surgically treated cases followed from one to three years, satisfactory results were obtained in 24 cases. Histologically, localized fibrosis or granulomatous changes or both were noted in several cases.

Effect of defects on molecular mobility in liquid water

Abstract: LIQUID water is a totally connected random network of hydrogen bonds, the connectivity lying well above the percolation threshold1–3 But despite this extensive association of hydrogen bonds with strengths greater than the thermal energy, the diffusion and rotation rates of water molecules at ambient temperatures are comparable to those of non-associated simple liquids. Many experiments have indicated that the random tetrahedral network cannot be perfect but must contain defects, which are characterized geometrically by the presence of an extra (fifth) molecule in the first coordination shell, or topologically by the presence of 'bifurcated' hydrogen bonds4–7. Here we use molecular-dynamics simulations to examine the effect of such defects on molecular mobility in water. We find that they provide pathways of lower energy between different tetrahedral local arrangements, thus acting as 'catalysts'. The anomalous mobility of water under compression8,9 and the decreased mobility in hydrophobic hydration shells10,11 can be interpreted on the same basis. We suggest that our results are relevant to studies on 'stretched' water12,13.

Properties and function of lysyl oxidase.

Abstract: Lysyl oxidase catalyzes the oxidation of peptidyl lysine to alpha-aminoadipic-delta-semialdehyde, the precursor to the covalent crosslinkages that stabilize fibers of elastin and collagen. This enzyme contains both copper and a carbonyl cofactor consistent with an o-quinone. The proposed mechanism of action is derived from available kinetic and chemical data and also can account for mechanism-based inhibition of the enzyme by specific monoamines and diamines. Recent evidence for biosynthetic precursors and for the regulation of lysyl oxidase in fibrotic and malignant diseases is discussed.

Occupational physical demands, knee bending, and knee osteoarthritis : results from the framingham study

Abstract: We sought to assess occupational joint use and osteoarthritis (OA) longitudinally in a large population with multiple occupations. Subjects were members of the Framingham Heart Study cohort followed over 40 years with occupational status assessed at the beginning of the Heart Study [from Examination 1 (1948-51) through Examination 6 (1958-61)] and knee OA assessed by weight bearing knee radiograph at Examination 18 (1983-85) when mean age of subjects was 73 years. Each subject's job was characterized by its level of physical demand and whether the job was associated with knee bending. Odds ratios (OR) testing the association of job demand with OA were adjusted by logistic regression for age, body mass, knee injury history, smoking, and educational level. Men whose jobs required knee bending and at least medium physical demands had higher rates of later radiographic knee OA (at least definite osteophytes) than men whose jobs required neither (43.4 vs 26.8%; OR of OA = 2.22, 95% CI 1.38, 3.58). Rates of severe radiographic OA (osteophytes and joint space narrowing) and of bilateral radiographic OA were also significantly increased in these men. Few women had jobs requiring knee bending or that were physically demanding and these jobs were generally unassociated with later radiographic OA. Only a small number of men (n = 28) had symptomatic knee OA, and we could not confirm that it was associated with occupation in men. Thus, among men, occupations which combine knee bending and physical demands may be an important cause of radiographic OA.

Prefrontostriatal connections in relation to cortical architectonic organization in rhesus monkeys.

Abstract: Prefrontostriatal connections were investigated in rhesus monkeys using the autoradiographic technique to examine whether there are systematic relationships with regard to the architectonic organization of the prefrontal cortex. On the basis of progressive laminar elaboration, the different regions of the prefrontal cortex can be grouped into two architectonic trends. The dorsal trend, which begins in the medial proisocortical areas, can be followed through the dorsolateral prefrontal cortex, culminating in the dorsal arcuate region. The ventral trend, which originates in the orbital proisocortex, can be traced through the inferior prefrontal convexity to the ventral arcuate region. The results show that the main connections from the prefrontal cortex to the striatum are to the head and body of the caudate nucleus. These connections are topographically organized. Medial and dorsal prefrontal areas project predominantly to the dorsal and central portion of the head and body of the caudate nucleus, whereas orbital and inferior prefrontal areas are related mainly to the ventral and central portion. Moreover, prefrontostriatal connections have a medial-lateral topography. Medial and orbital prefrontal areas project medially in the head and body of the caudate nucleus, whereas the dorsal and ventral arcuate regions project laterally, adjacent to the internal capsule. The prefrontal regions above and below the principal sulcus project mainly to the intermediate sector of the head and body of the nucleus. However, there appears to be some degree of overlap of corticostriatal projections from the dorsal and ventral prefrontal regions, as well as within each trend. Relatively minor projections are directed to the putamen as well as to the tail of the caudate nucleus from certain subregions of the prefrontal cortex. Thus the distribution of prefrontostriatal connections seems to reflect the architectonic organization of the prefrontal cortex. Possible functional aspects of prefrontostriatal connectivity are considered in the light of behavioral and physiological studies.