Boston University

About: Boston University is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 48688 authors who have published 119622 publications receiving 6276020 citations. The organization is also known as: BU & Boston U.

Switching Cognitive Gears: From Habits of Mind to Active Thinking

Abstract: The phrase "switching cognitive gears" is used to call attention to the fact that cognitive functioning involves the capacity to shift between cognitive modes, from automatic processing to conscious engagement and back again. Effectiveness may be as much a function of an actor's capacity to sense when a switch is appropriate, as to process in one or another mode. In this paper the authors develop a perspective on the switch from automatic to active thinking and the conditions that provoke it. They apply the perspective to work settings and identify types of situations in which actors are expected to switch from habits of mind to active thinking. They propose further work to develop a framework for understanding the switch from active thinking to automatic.

Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection

Abstract: In the modified intention-to-treat analysis, tuberculosis developed in 7 of 3986 subjects in the combination-therapy group (cumulative rate, 0.19%) and in 15 of 3745 subjects in the isoniazid-only group (cumulative rate, 0.43%), for a difference of 0.24 percentage points. Rates of treatment completion were 82.1% in the combination-therapy group and 69.0% in the isoniazid-only group (P<0.001). Rates of permanent drug discontinuation owing to an adverse event were 4.9% in the combination-therapy group and 3.7% in the isoniazid-only group (P = 0.009). Rates of investigator-assessed drug-related hepatotoxicity were 0.4% and 2.7%, respectively (P<0.001). Conclusions The use of rifapentine plus isoniazid for 3 months was as effective as 9 months of isoniazid alone in preventing tuberculosis and had a higher treatment-completion rate. Long-term safety monitoring will be important. (Funded by the Centers for Disease Control and Prevention; PREVENT TB ClinicalTrials.gov number, NCT00023452.)

Subduction zone infancy: Examples from the Eocene Izu-Bonin-Mariana and Jurassic California arcs

Abstract: A new model for the earliest stages in the evolution of subduction zones is developed from recent geologic studies of the Izu-Bonin-Mariana (IBM) arc system and then applied to Late Jurassic ophiolites of Cailfornia. The model accounts for several key observations about the earliest stages in the evolution of the IBM system: (1) subduction nucleated along an active transform boundary, which separated younger, less-dense lithosphere in the west from older, more-dense lithosphere to the east; (2) initial arc magmatic activity occupied a much broader zone than existed later; (3) initial magmatism extended up to the modern trench, over a region now characterized by subnormal heat flow; (4) early are magmatism was characterized by depleted (tholeiitic) and ultra-depleted (boninitic) magmas, indicating that melting was more extensive and involved more depleted mantle than is found anywhere else on earth; (5) early arc magmatism was strongly extensional, with crust forming in a manner similar to slow-spreading ridges; and (6) crust production rates were 120 to 180 km 3 /km-Ma, several times greater than for mature arc systems. These observations require that the earliest stages of subduction involve rapid retreat of the trench; we infer that this resulted from continuous subsidence of denser lithosphere along the transform fault. This resulted in strong extension and thinning of younger, more buoyant lithosphere to the west. This extension was accompanied by the flow of water from the sinking oceanic lithosphere to the base of the extending lithosphere and the underlying asthenosphere. Addition of water and asthenospheric upwelling led to catastrophic melting, which continued until lithosphere subsidence was replaced by lithospheric subduction . Application of the subduction-zone infancy model to the Late Jurassic ophiolites of California provides a framework in which to understand the rapid formation of oceanic crust with strong arc affinities between the younger Sierran magmatic arc and the Franciscan subduction complex, provides a mechanism for the formation and subsidence of the Great Valley forearc basin, and explains the limited duration of high-T, high-P metamorphism experienced by Franciscan melanges.

First M87 Event Horizon Telescope Results. II. Array and Instrumentation

Abstract: The Event Horizon Telescope (EHT) is a very long baseline interferometry (VLBI) array that comprises millimeter- and submillimeter-wavelength telescopes separated by distances comparable to the diameter of the Earth. At a nominal operating wavelength of ~1.3 mm, EHT angular resolution (λ/D) is ~25 μas, which is sufficient to resolve nearby supermassive black hole candidates on spatial and temporal scales that correspond to their event horizons. With this capability, the EHT scientific goals are to probe general relativistic effects in the strong-field regime and to study accretion and relativistic jet formation near the black hole boundary. In this Letter we describe the system design of the EHT, detail the technology and instrumentation that enable observations, and provide measures of its performance. Meeting the EHT science objectives has required several key developments that have facilitated the robust extension of the VLBI technique to EHT observing wavelengths and the production of instrumentation that can be deployed on a heterogeneous array of existing telescopes and facilities. To meet sensitivity requirements, high-bandwidth digital systems were developed that process data at rates of 64 gigabit s^(−1), exceeding those of currently operating cm-wavelength VLBI arrays by more than an order of magnitude. Associated improvements include the development of phasing systems at array facilities, new receiver installation at several sites, and the deployment of hydrogen maser frequency standards to ensure coherent data capture across the array. These efforts led to the coordination and execution of the first Global EHT observations in 2017 April, and to event-horizon-scale imaging of the supermassive black hole candidate in M87.

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

Abstract: Bacterial persistence is a state in which a sub-population of dormant cells, or 'persisters', tolerates antibiotic treatment. Bacterial persisters have been implicated in biofilms and in chronic and recurrent infections. Despite this clinical relevance, there are currently no viable means for eradicating persisters. Here we show that specific metabolic stimuli enable the killing of both Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) persisters with aminoglycosides. This potentiation is aminoglycoside-specific, it does not rely on growth resumption and it is effective in both aerobic and anaerobic conditions. It proceeds by the generation of a proton-motive force which facilitates aminoglycoside uptake. Our results demonstrate that persisters, although dormant, are primed for metabolite uptake, central metabolism and respiration. We show that aminoglycosides can be used in combination with specific metabolites to treat E. coli and S. aureus biofilms. Furthermore, we demonstrate that this approach can improve the treatment of chronic infections in a mouse urinary tract infection model. This work establishes a strategy for eradicating bacterial persisters that is based on metabolism, and highlights the importance of the metabolic environment to antibiotic treatment.