Boston University

About: Boston University is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 48688 authors who have published 119622 publications receiving 6276020 citations. The organization is also known as: BU & Boston U.

A common genetic variant is associated with adult and childhood obesity.

Abstract: Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

New insights into the classification and nomenclature of cortical GABAergic interneurons

Abstract: A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

Linking control systems to business unit strategy: impact on performance

Abstract: Rooted in contingency theory, this paper examines linkages between strategy, incentive bonus system and effectiveness at the strategic busines unit (SBU) level within diversified firms. Data from 58 SBUs reveal (1) that greater reliance on long-run criteria as well as subjective (non-formula) approaches for determining the SBU general managers’ bonus contributes to effectiveness in the case of ‘build’ SBUs but hampers it in the case of ‘harvest’ SBUs, and (2) that the relationship between extent of reliance on short-run criteria and effectiveness is virtually independent of SBU strategy.

A real-time matching system for large fingerprint databases

Abstract: With the current rapid growth in multimedia technology, there is an imminent need for efficient techniques to search and query large image databases. Because of their unique and peculiar needs, image databases cannot be treated in a similar fashion to other types of digital libraries. The contextual dependencies present in images, and the complex nature of two-dimensional image data make the representation issues more difficult for image databases. An invariant representation of an image is still an open research issue. For these reasons, it is difficult to find a universal content-based retrieval technique. Current approaches based on shape, texture, and color for indexing image databases have met with limited success. Further, these techniques have not been adequately tested in the presence of noise and distortions. A given application domain offers stronger constraints for improving the retrieval performance. Fingerprint databases are characterized by their large size as well as noisy and distorted query images. Distortions are very common in fingerprint images due to elasticity of the skin. In this paper, a method of indexing large fingerprint image databases is presented. The approach integrates a number of domain-specific high-level features such as pattern class and ridge density at higher levels of the search. At the lowest level, it incorporates elastic structural feature-based matching for indexing the database. With a multilevel indexing approach, we have been able to reduce the search space. The search engine has also been implemented on Splash 2-a field programmable gate array (FPGA)-based array processor to obtain near-ASIC level speed of matching. Our approach has been tested on a locally collected test data and on NIST-9, a large fingerprint database available in the public domain.

Predicting the 30-Year Risk of Cardiovascular Disease The Framingham Heart Study

Abstract: Background— Present cardiovascular disease (CVD) risk prediction algorithms were developed for a ≤10-year follow up period. Clustering of risk factors at younger ages and increasing life expectancy suggest the need for longer-term risk prediction tools. Methods and Results— We prospectively followed 4506 participants (2333 women) of the Framingham Offspring cohort aged 20 to 59 years and free of CVD and cancer at baseline examination in 1971–1974 for the development of “hard” CVD events (coronary death, myocardial infarction, stroke). We used a modified Cox model that allows adjustment for competing risk of noncardiovascular death to construct a prediction algorithm for 30-year risk of hard CVD. Cross-validated survival C statistic and calibration χ2 were used to assess model performance. The 30-year hard CVD event rates adjusted for the competing risk of death were 7.6% for women and 18.3% for men. Standard risk factors (male sex, systolic blood pressure, antihypertensive treatment, total and high-densit...