Boston University

About: Boston University is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 48688 authors who have published 119622 publications receiving 6276020 citations. The organization is also known as: BU & Boston U.

Scaling behaviour in the dynamics of an economic index

Abstract: THE large-scale dynamical properties of some physical systems depend on the dynamical evolution of a large number of nonlinearly coupled subsystems. Examples include systems that exhibit self-organized criticality1 and turbulence2,3. Such systems tend to exhibit spatial and temporal scaling behaviour–power–law behaviour of a particular observable. Scaling is found in a wide range of systems, from geophysical4 to biological5. Here we explore the possibility that scaling phenomena occur in economic systemsa-especially when the economic system is one subject to precise rules, as is the case in financial markets6–8. Specifically, we show that the scaling of the probability distribution of a particular economic index–the Standard & Poor's 500–can be described by a non-gaussian process with dynamics that, for the central part of the distribution, correspond to that predicted for a Levy stable process9–11. Scaling behaviour is observed for time intervals spanning three orders of magnitude, from 1,000 min to 1 min, the latter being close to the minimum time necessary to perform a trading transaction in a financial market. In the tails of the distribution the fall-off deviates from that for a Levy stable process and is approximately exponential, ensuring that (as one would expect for a price difference distribution) the variance of the distribution is finite. The scaling exponent is remarkably constant over the six-year period (1984-89) of our data. This dynamical behaviour of the economic index should provide a framework within which to develop economic models.

Age-specific Incidence Rates of Myocardial Infarction and Angina in Women With Systemic Lupus Erythematosus: Comparison With the Framingham Study

Abstract: The authors ascertained cardiovascular events (myocardial infarction and angina pectoris) in 498 women with systemic lupus erythematosus seen at the University of Pittsburgh Medical Center from 1980 to 1993 (3,522 person-years). Subjects were stratified by age, and cardiovascular event incidence rates were determined. The authors compared these rates with cardiovascular event rates were determined. The authors compared these rates with cardiovascular event rates occurring over the same time period in 2,208 women of similar age participating in the Framingham Offspring Study (17,519 person-years). Age-specific rate ratios were computed to determine whether the cardiovascular events in the lupus cohort were greater than expected. The risk factors associated with cardiovascular events in women with lupus were determined. There were 33 first events (11 myocardial infarction, 10 angina pectoris, and 12 both angina pectoris and myocardial infarction) after the diagnosis of lupus: two thirds were under the age of 55 years at the time of event. Women with lupus in the 35- to 44-year age group were over 50 times more likely to have a myocardial infarction than were women of similar age in the Framingham Offspring Study (rate ratio = 52.43, 95% confidence interval 21.6-98.5). Older age at lupus diagnosis, longer lupus disease duration, longer duration of corticosteroid use, hypercholesterolemia, and postmenopausal status were more common in the women with lupus who had a cardiovascular event than in those who did not have an event. Premature cardiovascular disease is much more common in young premenopausal women with lupus than in a population sample. With the increased life expectancy of lupus patients due to improved therapy, cardiovascular disease has emerged as a significant threat to the health of these women. The impact of this problem has been underrecognized, with little focus placed on aggressive management of hypercholesterolemia and other possible risk factors.

Probability of stroke: a risk profile from the Framingham Study.

Abstract: A health risk appraisal function has been developed for the prediction of stroke using the Framingham Study cohort. The stroke risk factors included in the profile are age, systolic blood pressure, the use of antihypertensive therapy, diabetes mellitus, cigarette smoking, prior cardiovascular disease (coronary heart disease, cardiac failure, or intermittent claudication), atrial fibrillation, and left ventricular hypertrophy by electrocardiogram. Based on 472 stroke events occurring during 10 years' follow-up from biennial examinations 9 and 14, stroke probabilities were computed using the Cox proportional hazards model for each sex based on a point system. On the basis of the risk factors in the profile, which can be readily determined on routine physical examination in a physician's office, stroke risk can be estimated. An individual's risk can be related to the average risk of stroke for persons of the same age and sex. The information that one's risk of stroke is several times higher than average may provide the impetus for risk factor modification. It may also help to identify persons at substantially increased stroke risk resulting from borderline levels of multiple risk factors such as those with mild or borderline hypertension and facilitate multifactorial risk factor modification.