British Hospital

About: British Hospital is a healthcare organization based out in Montevideo, Uruguay. It is known for research contribution in the topics: Population & Hazard ratio. The organization has 445 authors who have published 358 publications receiving 7878 citations. The organization is also known as: British Hospital.

Late post-partum dyspareunia: does delivery play a role?

Abstract: Summary Objective To study whether post-partum dyspareunia one year after a delivery is associated with characteristics of delivery: perineal trauma, obstetric interventions and women's experience. Methods A self-administered questionnaire on post-partum sexual function was mailed in May 2002 to all consecutive women who gave birth to a live-born term infant in a maternity unit, between January 2001 and June 2001. Obstetric data were abstracted from the hospital computerized medical database. Late dyspareunia was defined as pain during intercourse, one year after delivery. Multiple logistic regression modeling was used to select independent predictors of late post-partum dyspareunia. Results Seventy (27.6%) of the 254 women studied experienced late dyspareunia. There was no relation between late post-partum dyspareunia and neither the mode of delivery nor state of the perineum, including perineal laceration or episiotomy. Multiple logistic regression analysis showed that late post-partum dyspareunia was associated with dyspareunia before pregnancy, low satisfaction with delivery, and employment status. Conclusions Late post-partum dyspareunia seemed to be linked more with the mother's experience of childbirth than with perineal trauma. This hypothesis should be investigated further.

Expanding the importance of HMERF titinopathy: new mutations and clinical aspects.

Abstract: Hereditary myopathy with early respiratory failure (HMERF) is caused by titin A-band mutations in exon 344 and considered quite rare. Respiratory insufficiency is an early symptom. A collection of families and patients with muscle disease suggestive of HMERF was clinically and genetically studied. Altogether 12 new families with 19 affected patients and diverse nationalities were studied. Most of the patients were investigated using targeted next-generation sequencing; Sanger sequencing was applied in some of the patients and available family members. Histological data and muscle MRI findings were evaluated. Three families had several family members studied while the rest were single patients. Most patients had distal and proximal muscle weakness together with respiratory insufficiency. Five heterozygous TTN A-band mutations were identified of which two were novel. Also with the novel mutations the muscle pathology and imaging findings were compatible with the previous reports of HMERF. Our collection of 12 new families expands mutational spectrum with two new mutations identified. HMERF is not that rare and can be found worldwide, but maybe underdiagnosed. Diagnostic process seems to be complex as this study shows with mostly single patients without clear dominant family history.

Congenital atrophic dermatofibrosarcoma protuberans.

Abstract: A 16-year-old girl presented with a congenital atrophic plaque on the anterior aspect of her right leg. The lesion had slowly enlarged until she was 9 years of age; subsequently, several tumors appeared on the surface and later became reddish, hot, and mildly painful. Within a few months, all the tumors flattened and involuted. A previous biopsy showed a congenital fibroma. The patient was in good health; the physical examination, chest X-ray films, and laboratory studies were normal. No history of personal or familial diseases was recorded. Initially, the atrophic plaque measured 6 × 8 cm; shortly after, multiple 0.5–2 cm tumors appeared. These tumors alternated with atrophic and ill-defined livedo-like areas (Fig. 1). A satellite lesion, measuring 2 cm in diameter, was also observed. A new biopsy revealed dermatofibrosarcoma protuberans. Figure 1. (A) 6 × 8 cm plaque on the anterior aspect of the right leg. Multiple tumors alternate with atrophic and ill-defined livedo-like areas Download figure to PowerPoint Immunohistochemical findings included positive vimentin and CD34, and negative Factor XIIIa, S-100 protein, and muscle actin (Fig. 2). One month later, several tumors had almost disappeared. The patient was successfully treated with Mohs' micrographic surgery and remained disease free 9 months later. Figure 2. The cells are characteristically arranged in a ‘‘storiform’' pattern, sometimes centered around small blood vessels. Involvement of the subcutaneous fat is usual Download figure to PowerPoint

Ten-year persistence of antibody to hepatitis B surface antigen in healthcare workers vaccinated against hepatitis B virus, and response to booster vaccination.

Abstract: This study estimated the number of HCWs with protective antibody levels 5 and 10 years after HBV vaccination. Kaplan-Meier probabilities of protective levels were 0.95 at 60 days after vaccination, 0.87 at 5 years, and 0.79 at 10 years. Those without protective levels displayed good response 7 and 30 days after a booster.

Differential patterns of memory performance in relapsing, remitting and secondary progressive multiple sclerosis.

Abstract: Background: Memory dysfunction is common in multiple sclerosis (MS). A retrieval failure has been reported as the primary cause for the memory deficits, although some studies also described a faulty acquisition. Aims: The aim of the study was to examine memory function in relapsing remitting (RR) and secondary progressive (SP) MS patients, analyze the patterns of performance and to investigate whether disease course influences this performance. Design and settings: Case-control prospective study conducted in a clinical setting. Materials and Methods: Fifty-five RR, 23 SP MS patients and 80 normal subjects were evaluated with a comprehensive neuropsychological battery. Memory was assessed with tasks from the Signoret memory battery. Attention and executive function were also assessed. Statistical Analysis : Univariate analysis of variance, Mann-Whitney U-test, multivariate logistic regression and Chi-square test were used as appropriate. Results: MS patients performed significantly worse than controls on almost all measures of memory ( P <0,001). MS subgroups differed in tasks of delayed recall (logical memory- P =0,019; wordlist delayed recall, P <0,001), semantic cued recall ( P <0,001), recognition trials ( P =0,006) rate of forgetting ( P <0,001) and confabulation and intrusion errors ( P =0,004). Conclusions: Memory is consistently impaired in MS patients and disease course differentially affects the pattern of performance. SP patients show greater difficulties and a more pervasive pattern of dysfunction than RR patients. Delayed recall was the most affected memory measure and performance on this task discriminates between RR and SP MS patients. Relapsing remitting patients performed within the mildly impaired range while SP patients showed a moderate to severe impairment.