Brown University

About: Brown University is a education organization based out in Providence, Rhode Island, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 35778 authors who have published 90896 publications receiving 4471489 citations. The organization is also known as: brown.edu & Brown.

Family of crack-tip fields characterized by a triaxiality parameter—II. Fracture applications

Abstract: C entral to the J-based fracture mechanics approach is the concept of J-dominance whereby J alone sets the stress level as well as the size scale of the zone of high stresses and strains. In Part I the idea of a J Q annulus was developed. Within the annulus, the plane strain plastic near-tip fields are members of a family of solutions parameterized by Q when distances are normalized by J σ 0 , where σ0is the yield stress, J and Q have distinct roles: J sets the size scale over which large stresses and strains develop while Q scales the near-tip stress distribution and the stress triaxiality achieved ahead of the crack. Specifically, negative (positive) Q values mean that the hydrostatic stress is reduced (increased) by Qσ0 from the Q = 0 plane strain reference state. Therefore Q provides a quantitative measure of crack-tip constraint, a term widely used in the literature concerning geometry and size effects on a material's resistance to fracture. These developments are discussed further in this paper. It is shown that the J Q approach considerably extends the range of applicability of fracture mechanics for shallow-crack geometries loaded in tension and bending, and deep-crack geometries loaded in tension. The J Q theory provides a framework to organize toughness data as a function of constraint and to utilize such data in engineering applications. Two methods for estimating Q at fully yielded conditions and an interpolation scheme are discussed. The effects of crack size and specimen type on fracture toughness are addressed.

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster

Abstract: Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we present a genome-wide chromatin landscape for Drosophila melanogaster based on eighteen histone modifications, summarized by nine prevalent combinatorial patterns. Integrative analysis with other data (non-histone chromatin proteins, DNase I hypersensitivity, GRO-Seq reads produced by engaged polymerase, short/long RNA products) reveals discrete characteristics of chromosomes, genes, regulatory elements and other functional domains. We find that active genes display distinct chromatin signatures that are correlated with disparate gene lengths, exon patterns, regulatory functions and genomic contexts. We also demonstrate a diversity of signatures among Polycomb targets that include a subset with paused polymerase. This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function.

Combined results of searches for the standard model Higgs boson in pp collisions at √s = 7 TeV

Abstract: Combined results are reported from searches for the standard model Higgs boson in proton-proton collisions at sqrt(s)=7 TeV in five Higgs boson decay modes: gamma pair, b-quark pair, tau lepton pair, W pair, and Z pair. The explored Higgs boson mass range is 110-600 GeV. The analysed data correspond to an integrated luminosity of 4.6-4.8 inverse femtobarns. The expected excluded mass range in the absence of the standard model Higgs boson is 118-543 GeV at 95% CL. The observed results exclude the standard model Higgs boson in the mass range 127-600 GeV at 95% CL, and in the mass range 129-525 GeV at 99% CL. An excess of events above the expected standard model background is observed at the low end of the explored mass range making the observed limits weaker than expected in the absence of a signal. The largest excess, with a local significance of 3.1 sigma, is observed for a Higgs boson mass hypothesis of 124 GeV. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-600 (110-145) GeV is estimated to be 1.5 sigma (2.1 sigma). More data are required to ascertain the origin of this excess.