Brown University

About: Brown University is a education organization based out in Providence, Rhode Island, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 35778 authors who have published 90896 publications receiving 4471489 citations. The organization is also known as: brown.edu & Brown.

Void nucleation by inclusion debonding in a crystal matrix

Abstract: In a numerical micromechanical study of void nucleation, a framework is used where constitutive relations are specified independently for the matrix, the void-nucleating particles and the interface. Plane strain analyses are carried out for a doubly periodic array of circular cylindrical particles. The particles are taken to be rigid and the elastic-plastic deformations of the matrix are described in terms of continuum crystalline plasticity, using a planar crystal model that allows for three slip systems. Comparison is made with void-nucleation predictions based on a corresponding flow theory of plasticity with isotropic hardening. The crystal model can give rise to shear localization at the particle-matrix interface and shear localization, which leads to large localized strains in the matrix, is found to inhibit decohesion. The role of the triaxiality of the stress state in determining whether decohesion or localization occurs first is investigated. A parameteric study is also carried out for a crystal matrix using two descriptions of the interface shear behaviour; one is periodic in the shear displacement across the interface, while the other allows for shear decohesion.

Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry

Abstract: To find inherited causes of autism-spectrum disorders, we studied families in which parents share ancestors, enhancing the role of inherited factors. We mapped several loci, some containing large, inherited, homozygous deletions that are likely mutations. The largest deletions implicated genes, including PCDH10 (protocadherin 10) and DIA1 (deleted in autism1, or c3orf58), whose level of expression changes in response to neuronal activity, a marker of genes involved in synaptic changes that underlie learning. A subset of genes, including NHE9 (Na+/H+ exchanger 9), showed additional potential mutations in patients with unrelated parents. Our findings highlight the utility of “homozygosity mapping” in heterogeneous disorders like autism but also suggest that defective regulation of gene expression after neural activity may be a mechanism common to seemingly diverse autism mutations.

Fault localization with nearest neighbor queries

Abstract: We present a method for performing fault localization using similar program spectra. Our method assumes the existence of a faulty run and a larger number of correct runs. It then selects according to a distance criterion the correct run that most resembles the faulty run, compares the spectra corresponding to these two runs, and produces a report of "suspicious" parts of the program. Our method is widely applicable because it does not require any knowledge of the programinput and no more information from the user than a classification of the runs as either "correct" or "faulty". To experimentally validate the viability of the method, we implemented it in a tool, WHITHER using basic block profiling spectra. We experimented with two different similarity measures and the Siemens suite of 132 programs with injected bugs. To measure the success of the tool, we developed a generic method for establishing the quality of a report. The method is based on the way an "ideal user" would navigate the program using the report to save effort during debugging. The best results we obtained were, on average, above 50%, meaning that our ideal user would avoid looking at half of the program.

Targeting natural killer cells and natural killer T cells in cancer.

Abstract: Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on the manipulation of NK and NKT cells. Recent studies have highlighted how the immune reactivity of NK and NKT cells is shaped by the environment in which they develop. The rational use of these cells in cancer immunotherapies awaits a better understanding of their effector functions, migratory patterns and survival properties in humans.