Institution
Brunel University London
Education•London, United Kingdom•
About: Brunel University London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Context (language use) & Large Hadron Collider. The organization has 10918 authors who have published 29515 publications receiving 893330 citations. The organization is also known as: Brunel & University of Brunel.
Papers published on a yearly basis
Papers
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TL;DR: A draft genome sequence of the red jungle fowl, Gallus gallus, provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes.
Abstract: We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to have its genome sequenced, the draft sequence of its genome--composed of approximately one billion base pairs of sequence and an estimated 20,000-23,000 genes--provides a new perspective on vertebrate genome evolution, while also improving the annotation of mammalian genomes. For example, the evolutionary distance between chicken and human provides high specificity in detecting functional elements, both non-coding and coding. Notably, many conserved non-coding sequences are far from genes and cannot be assigned to defined functional classes. In coding regions the evolutionary dynamics of protein domains and orthologous groups illustrate processes that distinguish the lineages leading to birds and mammals. The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture.
2,579 citations
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TL;DR: This work was supported in part by the Royal Society of the UK, the National Natural Science Foundation of China, and the Alexander von Humboldt Foundation of Germany.
2,404 citations
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TL;DR: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva).
Abstract: The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems, as established by test beam measurements and simulation studies, is described.
2,286 citations
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European Bioinformatics Institute1, University of California, Santa Cruz2, University of Lausanne3, University of Bern4, Broad Institute5, Massachusetts Institute of Technology6, Brunel University London7, Yale University8, University of Warsaw9, Ohio State University10, Pompeu Fabra University11, King's College London12
TL;DR: This work generates primary data, creates bioinformatics tools and provides analysis to support the work of expert manual gene annotators and automated gene annotation pipelines to identify and characterise gene loci to the highest standard.
Abstract: The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 years, the GENCODE consortium has been producing reference quality gene annotations to provide this foundational resource. The GENCODE consortium includes both experimental and computational biology groups who work together to improve and extend the GENCODE gene annotation. Specifically, we generate primary data, create bioinformatics tools and provide analysis to support the work of expert manual gene annotators and automated gene annotation pipelines. In addition, manual and computational annotation workflows use any and all publicly available data and analysis, along with the research literature to identify and characterise gene loci to the highest standard. GENCODE gene annotations are accessible via the Ensembl and UCSC Genome Browsers, the Ensembl FTP site, Ensembl Biomart, Ensembl Perl and REST APIs as well as https://www.gencodegenes.org.
2,095 citations
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TL;DR: It is concluded that in patients with angiographically proven symptomatic coronary atherosclerosis, alpha-tocopherol treatment substantially reduces the rate of non-fatal MI, with beneficial effects apparent after 1 year of treatment.
2,032 citations
Authors
Showing all 11074 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yang Yang | 171 | 2644 | 153049 |
Hongfang Liu | 166 | 2356 | 156290 |
Gavin Davies | 159 | 2036 | 149835 |
Marjo-Riitta Järvelin | 156 | 923 | 100939 |
Matt J. Jarvis | 144 | 1064 | 85559 |
Alexander Belyaev | 142 | 1895 | 100796 |
Louis Lyons | 138 | 1747 | 98864 |
Silvano Tosi | 135 | 1712 | 97559 |
John A Coughlan | 135 | 1312 | 96578 |
Kenichi Hatakeyama | 134 | 1731 | 102438 |
Kristian Harder | 134 | 1613 | 96571 |
Peter R Hobson | 133 | 1590 | 94257 |
Christopher Seez | 132 | 1256 | 89943 |
Liliana Teodorescu | 132 | 1471 | 90106 |
Umesh Joshi | 131 | 1249 | 90323 |