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Institution

Brunel University London

EducationLondon, United Kingdom
About: Brunel University London is a education organization based out in London, United Kingdom. It is known for research contribution in the topics: Context (language use) & Large Hadron Collider. The organization has 10918 authors who have published 29515 publications receiving 893330 citations. The organization is also known as: Brunel & University of Brunel.


Papers
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Journal ArticleDOI
TL;DR: Polymorphism in p53 may influence individual responsiveness to cancer therapy, and clinical response following cisplatin-based chemo-radiotherapy for advanced head and neck cancer is influenced by this polymorphism, cancers expressing 72R mutants having lower response rates than those expressing 72P mutants.

432 citations

Journal ArticleDOI
TL;DR: In this article, the authors offer a new theoretical perspective on the unique nature and function of job satisfaction change, or systematic improvement or decline in job satisfaction over time, using four diverse groups.
Abstract: This study offers a new theoretical perspective on the unique nature and function of job satisfaction change, or systematic improvement or decline in job satisfaction over time. Using four diverse ...

429 citations

Journal ArticleDOI
TL;DR: Vitellogenin, a yolk-precursor protein normally found only in the blood plasma of sexually mature female teleosts and other egg-laying vertebrates, was used as an indicator of exposure of male rainbow trout to exogenous estrogens.
Abstract: Vitellogenin, a yolk-precursor protein normally found only in the blood plasma of sexually mature female teleosts and other egg-laying vertebrates, was used as an indicator of exposure of male rainbow trout (Oncorhynchus mykiss) to exogenous estrogens. Vitellogenin concentrations were measured using a specific radioimmunoassay for trout. Cages containing adult male trout were placed at the points of discharge and at varying distances downstream of treated sewage effluent outfalls into the River Lea (UK) during the summer and winter months of 1992. After 3 weeks exposure at the majority of sites, fish held up to 15 km downstream of inputs showed an increase in plasma vitellogenin concentration, with statistically significant elevations up to 4.5 km downstream. A repeat survey in November 1992 below Harpenden sewage treatment works showed that the only two stations to give a significant response were 3 m and 1.6 km downstream of the outfall. This reduced effect compared to the first survey is thought to be due to dilution of both the influent sewage to the treatment works and of the river water itself by increased rainfall, the overall increase in dilution being approx. 36%. Trout were also placed in 15 raw water storage reservoirs in southeast England during the summer of 1993 for an exposure period of 6 weeks. No biologically significant increases in plasma vitellogenin concentration were observed in any of the reservoirs.

428 citations

Journal ArticleDOI
TL;DR: The lab-based studies demonstrated that all of the tested chemicals (known to be estrogenic and to cause reproductive effects in fish) also affected embryo production in P. antipodarum, making it potentially a sensitive test organism for assessing estrogenicity of chemicals with a relevance to their activity in vertebrates.

427 citations

Journal ArticleDOI
TL;DR: A robust protocol which was nonselective and reproducible, and a considerable reduction in analysis time compared with previous methods, is likely to provide an essential tool for further research into the pathways by which microplastics enter the environment.
Abstract: Microplastics (<5 mm) have been documented in environmental samples on a global scale. While these pollutants may enter aquatic environments via wastewater treatment facilities, the abundance of microplastics in these matrices has not been investigated. Although efficient methods for the analysis of microplastics in sediment samples and marine organisms have been published, no methods have been developed for detecting these pollutants within organic-rich wastewater samples. In addition, there is no standardized method for analyzing microplastics isolated from environmental samples. In many cases, part of the identification protocol relies on visual selection before analysis, which is open to bias. In order to address this, a new method for the analysis of microplastics in wastewater was developed. A pretreatment step using 30% hydrogen peroxide (H2O2) was employed to remove biogenic material, and focal plane array (FPA)-based reflectance micro-Fourier-transform (FT-IR) imaging was shown to successfully im...

426 citations


Authors

Showing all 11074 results

NameH-indexPapersCitations
Yang Yang1712644153049
Hongfang Liu1662356156290
Gavin Davies1592036149835
Marjo-Riitta Järvelin156923100939
Matt J. Jarvis144106485559
Alexander Belyaev1421895100796
Louis Lyons138174798864
Silvano Tosi135171297559
John A Coughlan135131296578
Kenichi Hatakeyama1341731102438
Kristian Harder134161396571
Peter R Hobson133159094257
Christopher Seez132125689943
Liliana Teodorescu132147190106
Umesh Joshi131124990323
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202380
2022235
20211,532
20201,475
20191,445
20181,345