Institution
Bulgarian Academy of Sciences
Government•Sofia, Bulgaria•
About: Bulgarian Academy of Sciences is a government organization based out in Sofia, Bulgaria. It is known for research contribution in the topics: Catalysis & Coupling constant. The organization has 17989 authors who have published 36276 publications receiving 642820 citations. The organization is also known as: Bulgarian Academy of Sciences,簡稱:BAS & Balgarska Akademiya na Naukite.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors prove stability estimates for the hyperbolic Dirichlet to Neumann map associated to the wave equation in anisotropic media, which is the basis for our work.
123 citations
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TL;DR: Genome-wide and high-density CRISPR-Cas9 “tag, mutate and enrich” mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance and suggest that interactions between non-DNA binding domains ofPARP1 influence cytotoxicity.
Abstract: PARP inhibitors (PARPi) target homologous recombination defective tumour cells via synthetic lethality. Genome-wide and high-density CRISPR-Cas9 "tag, mutate and enrich" mutagenesis screens identified single amino acid mutations in PARP1 that cause profound PARPi-resistance. These included PARP1 mutations outside of the DNA interacting regions of the protein, such as mutations in solvent exposed regions of the catalytic domain and clusters of mutations around points of contact between ZnF, WGR and HD domains. These mutations altered PARP1 trapping, as did a mutation found in a clinical case of PARPi resistance. These genetic studies reinforce the importance of trapped PARP1 as a key cytotoxic DNA lesion and suggest that interactions between non-DNA binding domains of PARP1 influence cytotoxicity. Finally, different mechanisms of PARPi resistance (BRCA1 reversion, PARP1, 53BP1, REV7 mutation) had differing effects on chemotherapy sensitivity, suggesting that the underlying mechanism of PARPi resistance likely influences the success of subsequent therapies.
123 citations
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TL;DR: Possible applications of polarization holography are demonstrated, including recording of pairs of superimposed holograms with one spatial frequency and logical operations on two data arrays recorded simultaneously in the material.
Abstract: Possible applications of polarization holography are demonstratedrecording of pairs of superimposed holograms with one spatial frequency; logical operations on two data arrays recorded simultaneously in the material; double-exposure holographic interferometry.
123 citations
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Norwegian University of Science and Technology1, Finnish Forest Research Institute2, University of Santiago de Compostela3, Environment Agency4, Çanakkale Onsekiz Mart University5, University of Navarra6, Jožef Stefan Institute7, Slovak Academy of Sciences8, University of Vechta9, Bulgarian Academy of Sciences10, University of Vienna11
TL;DR: The total nitrogen concentrations in mosses complement deposition measurements, helping to identify areas in Europe at risk from high nitrogen deposition at a high spatial resolution.
123 citations
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TL;DR: An increase in RA and RBP protein contents was observed under 24-h HS and HSR in light, in accordance with their role as chaperones and the function of RBP as a heat shock protein.
Abstract: Changes in chlorophyll content, ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) binding protein (RBP), Rubisco activase (RA), Rubisco large (LS) and small (SS) subunits, and electrolyte leakage were investigated in wheat leaf segments during heat stress (HS) for 1 h and for 24 h at 40 °C in darkness or in light, as well as after recovery from heat stress (HSR) for 24 h at 25 °C in light. The 24-h HS treatment in darkness decreased irreversibly photosynthetic pigments, soluble proteins, RBP, RA, Rubisco LS and SS. An increase in RA and RBP protein contents was observed under 24-h HS and HSR in light. This increase was in accordance with their role as chaperones and the function of RBP as a heat shock protein.
123 citations
Authors
Showing all 18074 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dimitri Bourilkov | 134 | 1489 | 96884 |
Eduardo De Moraes Gregores | 133 | 1454 | 92464 |
Georgi Sultanov | 132 | 1493 | 93318 |
Plamen Iaydjiev | 131 | 1285 | 87958 |
Pedro G Mercadante | 129 | 1331 | 86378 |
Jordan Damgov | 129 | 1195 | 85490 |
Roumyana Hadjiiska | 126 | 1003 | 73091 |
Mircho Rodozov | 124 | 972 | 70519 |
Cesar Augusto Bernardes | 124 | 965 | 70889 |
Viktor Matveev | 123 | 1212 | 73939 |
Ayda Beddall | 120 | 816 | 67063 |
Andrey Marinov | 119 | 893 | 57183 |
Mariana Vutova | 117 | 606 | 56698 |
Lester Packer | 112 | 751 | 63116 |
Patrick Couvreur | 111 | 678 | 56735 |