Showing papers by "Cairo University published in 2015"
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TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
5,792 citations
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Mohammad H. Forouzanfar1, Lily Alexander, H. Ross Anderson, Victoria F Bachman1 +733 more•Institutions (289)
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as discussed by the authors provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.
5,668 citations
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TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as mentioned in this paper, the authors estimated the quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
4,510 citations
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Mohammad H. Forouzanfar1, Lily Alexander1, H. Ross Anderson2, Victoria F Bachman1 +718 more•Institutions (295)
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as mentioned in this paper provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.
1,656 citations
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Christopher J L Murray1, Ryan M Barber, Kyle J Foreman2, Ayse Abbasoglu Ozgoren +608 more•Institutions (251)
TL;DR: Patterns of the epidemiological transition with a composite indicator of sociodemographic status, which was constructed from income per person, average years of schooling after age 15 years, and the total fertility rate and mean age of the population, were quantified.
1,609 citations
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TL;DR: The demand for flexible/wearable electronic devices that have aesthetic appeal and multi-functionality has stimulated the rapid development of flexible supercapacitors with enhanced electrochemical performance and mechanical flexibility and current progress made with graphene-based electrodes is summarized.
Abstract: The demand for flexible/wearable electronic devices that have aesthetic appeal and multi-functionality has stimulated the rapid development of flexible supercapacitors with enhanced electrochemical performance and mechanical flexibility. After a brief introduction to flexible supercapacitors, we summarize current progress made with graphene-based electrodes. Two recently proposed prototypes for flexible supercapacitors, known as micro-supercapacitors and fiber-type supercapacitors, are then discussed. We also present our perspective on the development of graphene-based electrodes for flexible supercapacitors.
971 citations
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Hamad Medical Corporation1, Wayne State University2, Tzu Chi University3, Taipei Medical University4, Columbia University5, University of Bologna6, University of South Florida7, Harbin Institute of Technology8, National Research Council9, University of South Carolina10, Purdue University11, University of Surrey12, Nara Medical University13, National Technical University of Athens14, University of Florence15, Cairo University16, United Arab Emirates University17, University of Illinois at Urbana–Champaign18, Creighton University19, Shanmugha Arts, Science, Technology & Research Academy20, University of Rome Tor Vergata21, University of Glasgow22, New York Medical College23, Mayo Clinic24
TL;DR: This review provides a roadmap for the design of successful anti-cancer strategies that overcome resistance to apoptosis for better therapeutic outcome in patients with cancer.
522 citations
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TL;DR: 3D high-performance hybrid supercapacitor systems based on graphene and MnO2 are developed that can store as much charge as a lead acid battery, yet they can be recharged in seconds compared with hours for conventional batteries.
Abstract: Supercapacitors now play an important role in the progress of hybrid and electric vehicles, consumer electronics, and military and space applications. There is a growing demand in developing hybrid supercapacitor systems to overcome the energy density limitations of the current generation of carbon-based supercapacitors. Here, we demonstrate 3D high-performance hybrid supercapacitors and microsupercapacitors based on graphene and MnO2 by rationally designing the electrode microstructure and combining active materials with electrolytes that operate at high voltages. This results in hybrid electrodes with ultrahigh volumetric capacitance of over 1,100 F/cm3. This corresponds to a specific capacitance of the constituent MnO2 of 1,145 F/g, which is close to the theoretical value of 1,380 F/g. The energy density of the full device varies between 22 and 42 Wh/l depending on the device configuration, which is superior to those of commercially available double-layer supercapacitors, pseudocapacitors, lithium-ion capacitors, and hybrid supercapacitors tested under the same conditions and is comparable to that of lead acid batteries. These hybrid supercapacitors use aqueous electrolytes and are assembled in air without the need for expensive “dry rooms” required for building today’s supercapacitors. Furthermore, we demonstrate a simple technique for the fabrication of supercapacitor arrays for high-voltage applications. These arrays can be integrated with solar cells for efficient energy harvesting and storage systems.
484 citations
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TL;DR: The study results should facilitate molecular genetic diagnostics of SRNS, etiologic classification for therapeutic studies, generation of genotype-phenotype correlations, and the identification of individuals in whom a targeted treatment for SRNS may be available.
Abstract: Steroid-resistant nephrotic syndrome (SRNS) is the second most frequent cause of ESRD in the first two decades of life. Effective treatment is lacking. First insights into disease mechanisms came from identification of single-gene causes of SRNS. However, the frequency of single-gene causation and its age distribution in large cohorts are unknown. We performed exon sequencing of NPHS2 and WT1 for 1783 unrelated, international families with SRNS. We then examined all patients by microfluidic multiplex PCR and next-generation sequencing for all 27 genes known to cause SRNS if mutated. We detected a single-gene cause in 29.5% (526 of 1783) of families with SRNS that manifested before 25 years of age. The fraction of families in whom a single-gene cause was identified inversely correlated with age of onset. Within clinically relevant age groups, the fraction of families with detection of the single-gene cause was as follows: onset in the first 3 months of life (69.4%), between 4 and 12 months old (49.7%), between 1 and 6 years old (25.3%), between 7 and 12 years old (17.8%), and between 13 and 18 years old (10.8%). For PLCE1, specific mutations correlated with age of onset. Notably, 1% of individuals carried mutations in genes that function within the coenzyme Q10 biosynthesis pathway, suggesting that SRNS may be treatable in these individuals. Our study results should facilitate molecular genetic diagnostics of SRNS, etiologic classification for therapeutic studies, generation of genotype-phenotype correlations, and the identification of individuals in whom a targeted treatment for SRNS may be available.
480 citations
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam2 +2802 more•Institutions (215)
TL;DR: In this paper, the branching fractions of the B meson (B-s(0)) and the B-0 meson decaying into two oppositely charged muons (mu(+) and mu(-)) were observed.
Abstract: The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilities, or branching fractions, of the strange B meson (B-s(0)) and the B-0 meson decaying into two oppositely charged muons (mu(+) and mu(-)) are especially interesting because of their sensitivity to theories that extend the standard model. The standard model predicts that the B-s(0)->mu(+)mu(-) and B-0 ->mu(+)mu(-) decays are very rare, with about four of the former occurring for every billion B-s(0) mesons produced, and one of the latter occurring for every ten billion B-0 mesons(1). A difference in the observed branching fractions with respect to the predictions of the standard model would provide a direction in which the standard model should be extended. Before the Large Hadron Collider (LHC) at CERN2 started operating, no evidence for either decay mode had been found. Upper limits on the branching fractions were an order of magnitude above the standard model predictions. The CMS (Compact Muon Solenoid) and LHCb(Large Hadron Collider beauty) collaborations have performed a joint analysis of the data from proton-proton collisions that they collected in 2011 at a centre-of-mass energy of seven teraelectronvolts and in 2012 at eight teraelectronvolts. Here we report the first observation of the B-s(0)->mu(+)mu(-) decay, with a statistical significance exceeding six standard deviations, and the best measurement so far of its branching fraction. Furthermore, we obtained evidence for the B-0 ->mu(+)mu(-) decay with a statistical significance of three standard deviations. Both measurements are statistically compatible with standard model predictions and allow stringent constraints to be placed on theories beyond the standard model. The LHC experiments will resume taking data in 2015, recording proton-proton collisions at a centre-of-mass energy of 13 teraelectronvolts, which will approximately double the production rates of B-s(0) and B-0 mesons and lead to further improvements in the precision of these crucial tests of the standard model.
467 citations
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HealthPartners1, King's College London2, Obafemi Awolowo University3, Fred Hutchinson Cancer Research Center4, University of Washington5, University of Liverpool6, Guy's and St Thomas' NHS Foundation Trust7, University of London8, University of Texas Southwestern Medical Center9, Memorial Sloan Kettering Cancer Center10, University of Toronto11, Institut Gustave Roussy12, University of Oxford13, Lund University14, Pontifical Catholic University of Chile15, University of Texas at Austin16, Union for International Cancer Control17, Peking University18, Boston Children's Hospital19, Indiana University20, Harvard University21, Cairo University22, University of Zambia23, University of North Carolina at Chapel Hill24, Leiden University25, European Institute of Oncology26, Amrita Institute of Medical Sciences and Research Centre27, Barwon Health28, Deakin University29, Peking Union Medical College30, Guangdong General Hospital31
TL;DR: To deliver safe, affordable, and timely cancer surgery to all, surgery must be at the heart of global and national cancer control planning and wide equity and economic gaps are found.
Abstract: Surgery is essential for global cancer care in all resource settings. Of the 15.2 million new cases of cancer in 2015, over 80% of cases will need surgery, some several times. By 2030, we estimate that annually 45 million surgical procedures will be needed worldwide. Yet, less than 25% of patients with cancer worldwide actually get safe, affordable, or timely surgery. This Commission on global cancer surgery, building on Global Surgery 2030, has examined the state of global cancer surgery through an analysis of the burden of surgical disease and breadth of cancer surgery, economics and financing, factors for strengthening surgical systems for cancer with multiple-country studies, the research agenda, and the political factors that frame policy making in this area. We found wide equity and economic gaps in global cancer surgery. Many patients throughout the world do not have access to cancer surgery, and the failure to train more cancer surgeons and strengthen systems could result in as much as US $6.2 trillion in lost cumulative gross domestic product by 2030. Many of the key adjunct treatment modalities for cancer surgery--e.g., pathology and imaging--are also inadequate. Our analysis identified substantial issues, but also highlights solutions and innovations. Issues of access, a paucity of investment in public surgical systems, low investment in research, and training and education gaps are remarkably widespread. Solutions include better regulated public systems, international partnerships, super-centralisation of surgical services, novel surgical clinical trials, and new approaches to improve quality and scale up cancer surgical systems through education and training. Our key messages are directed at many global stakeholders, but the central message is that to deliver safe, affordable, and timely cancer surgery to all, surgery must be at the heart of global and national cancer control planning.
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TL;DR: In this article, a comprehensive review is presented on the researches and developments related to superhydrophobicity phenomena, fabrication of super-hydrophobic surface and applications, and significant attention is paid to state of the art on corrosion performance of super hydrophobic coatings.
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Harvard University1, Linköping University2, University of California, San Diego3, University of North Carolina at Chapel Hill4, Emory University5, University of Bari6, Alderson Broaddus University7, Nara Medical University8, National Technical University of Athens9, Mayo Clinic10, University of Florence11, Cairo University12, United Arab Emirates University13, University of Illinois at Urbana–Champaign14, University of Rome Tor Vergata15, New York Medical College16, Purdue University17, Wayne State University18, University of Glasgow19, Karolinska Institutet20
TL;DR: 10 important aspects of tumor angiogenesis and the pathological tumor vasculature which would be well suited as targets for anti-angiogenic therapy are identified and 10 plant-derived compounds could be combined to constitute a broader acting and more effective inhibitory cocktail at doses that would not be likely to cause excessive toxicity.
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TL;DR: An asymmetric supercapacitor composed of mesoporous CuCo2O4 nanowires for the positive electrode and activated carbon for the negative electrode demonstrates an ultrahigh energy density of 42.8 Wh kg 1 with a power density of 15 kW kg 1 plus excellent cycle life as discussed by the authors.
Abstract: The search for faster, safer, and more efficient energy storage systems continues to inspire researchers to develop new energy storage materials with ultrahigh performance. Mesoporous nanostructures are interesting for supercapacitors because of their high surface area, controlled porosity, and large number of active sites, which promise the utilization of the full capacitance of active materials. Herein, highly ordered mesoporous CuCo2O4 nanowires have been synthesized by nanocasting from a silica SBA-15 template. These nanowires exhibit superior pseudocapacitance of 1210 F g–1 in the initial cycles. Electroactivation of the electrode in the subsequent 250 cycles causes a significant increase in capacitance to 3080 F g–1. An asymmetric supercapacitor composed of mesoporous CuCo2O4 nanowires for the positive electrode and activated carbon for the negative electrode demonstrates an ultrahigh energy density of 42.8 Wh kg–1 with a power density of 15 kW kg–1 plus excellent cycle life. We also show that two a...
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TL;DR: A distinct profile of cytokine imbalance in SLE patients was showed and reduction in IFN-γ (TH1) and TGF-β1 (Treg) with the elevation in IL-6 and IL-17 (TH17) could imply skewing of T-cells toward TH17 cells.
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TL;DR: The biological roles of bacterial volatile compounds in inter- and intraspecies bacterial interactions are described, a new and yet unexplored research area, with potential clinical and industrial applications.
Abstract: Bacterial interactions with neighboring microorganisms via production of small metabolites enable bacteria to respond and adapt to environmental changes. The study of intercellular interactions primarily focused on soluble metabolites, but bacteria also produce and release into their headspace a wide variety of volatile secondary metabolites, the ecological roles of which have generally been overlooked. However, bacterial volatile compounds are known to contribute to interkingdom interactions (plant, fungi and nematodes), and recent studies also identified their at-a-distance influence on bacterial behavior. The present review describes the biological roles of bacterial volatile compounds in inter- and intraspecies bacterial interactions, a new and yet unexplored research area, with potential clinical and industrial applications.
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07 Feb 2015
TL;DR: This educational review will simply define and calculate the accuracy, sensitivity, specificity, positive andnegative predictive values and positive and negative likelihood ratios of a hypothetical test.
Abstract: Emergency physicians, like other specialists, are faced with different patients and various situations each day. They have to use ancillary diagnostic tools like laboratory tests and imaging studies to be able to manage them. In most cases, numerous tests are available. Tests with the least error and the most accuracy are more desirable. The power of a test to separate patients from healthy ones determines its accuracy and diagnostic value. Therefore, a test with 100% accuracy should be the first choice. This does not happen in reality as the accuracy of a test varies for different diseases and in different situations. For example, the value of D-dimer for diagnosing pulmonary embolism varies based on pre-test probability. It shows high accuracy in low risk patient and low accuracy in high risk ones. The characteristics of a test that reflects the aforementioned abilities are accuracy, sensitivity, specificity, positive and negative predictive values and positive and negative likelihood ratios. In this educational review, we will simply define and calculate the accuracy, sensitivity, and specificity of a hypothetical test.
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TL;DR: The combined Pecs I and II block is a simple, easy-to-learn technique that produces good analgesia for radical breast surgery.
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01 Sep 2015TL;DR: ASTD, an Arabic social sentiment analysis dataset gathered from Twitter, consists of about 10,000 tweets which are classified as objective, subjective positive, subjective negative, and subjective mixed.
Abstract: This paper introduces ASTD, an Arabic social sentiment analysis dataset gathered from Twitter. It consists of about 10,000 tweets which are classified as objective, subjective positive, subjective negative, and subjective mixed. We present the properties and the statistics of the dataset, and run experiments using standard partitioning of the dataset. Our experiments provide benchmark results for 4 way sentiment classification on the dataset.
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2204 more•Institutions (181)
TL;DR: In this paper, the performance of the Cern LHC detector for photon reconstruction and identification in proton-proton collisions at a centre-of-mass energy of 8 TeV at the CERN LHC is described.
Abstract: A description is provided of the performance of the CMS detector for photon reconstruction and identification in proton-proton collisions at a centre-of-mass energy of 8 TeV at the CERN LHC. Details are given on the reconstruction of photons from energy deposits in the electromagnetic calorimeter (ECAL) and the extraction of photon energy estimates. The reconstruction of electron tracks from photons that convert to electrons in the CMS tracker is also described, as is the optimization of the photon energy reconstruction and its accurate modelling in simulation, in the analysis of the Higgs boson decay into two photons. In the barrel section of the ECAL, an energy resolution of about 1% is achieved for unconverted or late-converting photons from H→γγ decays. Different photon identification methods are discussed and their corresponding selection efficiencies in data are compared with those found in simulated events.
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TL;DR: In this article, the authors investigate the moderating effect of Islamic religiosity on the relationship between Muslim customer perceived value (MCPV) and Muslim customer satisfaction, and find that Islam's religiosity moderates the effects of Islamic physical attributes value and Islamic non-physical attributes value on Muslim customers' satisfaction.
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TL;DR: Women with an MHV have only a 58% chance of experiencing an uncomplicated pregnancy with a live birth and their markedly increased mortality and morbidity warrant extensive prepregnancy counseling and centralization of care.
Abstract: Background - Pregnant women with a mechanical heart valve (MHV) are at a heightened risk of a thrombotic event, and their absolute need for adequate anticoagulation puts them at considerable risk of bleeding and, with some anticoagulants, fetotoxicity. Methods and Results - Within the prospective, observational, contemporary, worldwide Registry of Pregnancy and Cardiac disease (ROPAC), we describe the pregnancy outcome of 212 patients with an MHV. We compare them with 134 patients with a tissue heart valve and 2620 other patients without a prosthetic valve. Maternal mortality occurred in 1.4% of the patients with an MHV, in 1.5% of patients with a tissue heart valve (P=1.000), and in 0.2% of patients without a prosthetic valve (P=0.025). Mechanical valve thrombosis complicated pregnancy in 10 patients with an MHV (4.7%). In 5 of these patients, the valve thrombosis occurred in the first trimester, and all 5 patients had been switched to some form of heparin. Hemorrhagic events occurred in 23.1% of patients with an MHV, in 5.1% of patients with a tissue heart valve (P<0.001), and in 4.9% of patients without a prosthetic valve (P<0.001). Only 58% of the patients with an MHV had a pregnancy free of serious adverse events compared with 79% of patients with a tissue heart valve (P<0.001) and 78% of patients without a prosthetic valve (P<0.001). Vitamin K antagonist use in the first trimester compared with heparin was associated with a higher rate of miscarriage (28.6% versus 9.2%; P<0.001) and late fetal death (7.1% versus 0.7%; P=0.016). Conclusions - Women with an MHV have only a 58% chance of experiencing an uncomplicated pregnancy with a live birth. The markedly increased mortality and morbidity warrant extensive prepregnancy counseling and centralization of care.
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TL;DR: In this study, a series of biobased polyols were prepared from olive, canola, grape seed, linseed, and castor oil using a novel, solvent/catalyst-free synthetic method and the molecular structures of the polyols and the resulting polyurethane were characterized.
Abstract: In this study, a series of biobased polyols were prepared from olive, canola, grape seed, linseed, and castor oil using a novel, solvent/catalyst-free synthetic method. The biobased triglyceride oils were first oxidized into epoxidized vegetable oils with formic acid and hydrogen peroxide, followed by ring-opening reaction with castor oil fatty acid. The molecular structures of the polyols and the resulting polyurethane were characterized. The effects of cross-linking density and the structures of polyols on the thermal, mechanical, and shape memory properties of the polyurethanes were also investigated.
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William H. Goodson1, Leroy Lowe2, David O. Carpenter3, Michael Gilbertson +177 more•Institutions (105)
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Abstract: Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.
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TL;DR: In this paper, a review of P-glycoprotein (P-gp) inhibitors/blockers is presented, focusing only on major classes of naturally occurring inhibitors viz., flavonoids, coumarins, terpenoids, alkaloids and saponins.
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam +2353 more•Institutions (181)
TL;DR: In this paper, a search for a heavy Higgs boson in the H to WW and H to ZZ decay channels is reported, based upon proton-proton collision data samples corresponding to an integrated luminosity of up to 5.1 inverse femtobarns at sqrt(s)=7 TeV and up to 19.7 inverse femto-bars at square root of 8 TeV, recorded by the CMS experiment at the CERN LHC.
Abstract: A search for a heavy Higgs boson in the H to WW and H to ZZ decay channels is reported. The search is based upon proton-proton collision data samples corresponding to an integrated luminosity of up to 5.1 inverse femtobarns at sqrt(s)=7 TeV and up to 19.7 inverse femtobarns at sqrt(s)=8 TeV, recorded by the CMS experiment at the CERN LHC. Several final states of the H to WW and H to ZZ decays are analyzed. The combined upper limit at the 95% confidence level on the product of the cross section and branching fraction exclude a Higgs boson with standard model-like couplings and decays in the range 145 < m[H] < 1000 GeV. We also interpret the results in the context of an electroweak singlet extension of the standard model.
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University of Auckland1, University of British Columbia2, University of Oslo3, Mario Negri Institute for Pharmacological Research4, University of Texas Health Science Center at Tyler5, University College Cork6, Johns Hopkins University7, University of Florence8, Cairo University9, United Arab Emirates University10, University of Rome Tor Vergata11, University of Rochester12, University of Glasgow13, Creighton University14, Nara Medical University15, New York Medical College16, University of Illinois at Urbana–Champaign17, Purdue University18, Louisiana State University in Shreveport19, University of Alabama at Birmingham20
TL;DR: Vitamin D and B, selenium, carotenoids, PARP inhibitors, resveratrol, and isothiocyanates are highlighted as priority approaches against genomic instability.
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TL;DR: The results showed that targeted MTX delivery might be achieved using topically applied niosomes for enhanced treatment of psoriasis.
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Duke University1, Deakin University2, Central European Institute of Technology3, University of Barcelona4, OhioHealth5, Hebrew University of Jerusalem6, French Institute of Health and Medical Research7, University of Naples Federico II8, Autonomous University of Barcelona9, Cairo University10, University of Zagreb11, Mater Misericordiae University Hospital12
TL;DR: The International Collaboration on Endocarditis-PLUS (ICEPLUS) is a prospective cohort of consecutively enrolled patients with definite infective endocarditis from 29 centers in 16 countries.
Abstract: Background—Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. Methods and Results—The International Collaboration on Endocarditis–PLUS (ICE-PLUS) is a prospective cohort of consecutively enrolled patients with definite IE from 29 centers in 16 countries. We included patients from ICE-PLUS with definite left-sided, non–cardiac device–related IE who were enrolled between September 1, 2008, and December 31, 2012. A total of 1296 patients with left-sided IE were included. Surgical treatment was performed in 57% of the overall cohort and in 76% of patients with a surgical indication. Reasons for nonsurgical treatment included poor prognosis (33.7%), hemodynamic instability (19.8%), death before surgery (23.3%), stroke (22.7%), and sepsis (21%). Among patients with a surgical indication, surgical treatment was independently associated with the presence of severe aortic regurgitation, abscess, embolization...
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TL;DR: In this article, a simple one-step process for the synthesis and processing of laser-scribed graphene/RuO 2 nanocomposites into electrodes that exhibit ultrahigh energy and power densities was demonstrated.