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Showing papers by "California Institute of Technology published in 2007"


Journal ArticleDOI
05 Mar 2007
TL;DR: A theoretical framework for analysis of consensus algorithms for multi-agent networked systems with an emphasis on the role of directed information flow, robustness to changes in network topology due to link/node failures, time-delays, and performance guarantees is provided.
Abstract: This paper provides a theoretical framework for analysis of consensus algorithms for multi-agent networked systems with an emphasis on the role of directed information flow, robustness to changes in network topology due to link/node failures, time-delays, and performance guarantees. An overview of basic concepts of information consensus in networks and methods of convergence and performance analysis for the algorithms are provided. Our analysis framework is based on tools from matrix theory, algebraic graph theory, and control theory. We discuss the connections between consensus problems in networked dynamic systems and diverse applications including synchronization of coupled oscillators, flocking, formation control, fast consensus in small-world networks, Markov processes and gossip-based algorithms, load balancing in networks, rendezvous in space, distributed sensor fusion in sensor networks, and belief propagation. We establish direct connections between spectral and structural properties of complex networks and the speed of information diffusion of consensus algorithms. A brief introduction is provided on networked systems with nonlocal information flow that are considerably faster than distributed systems with lattice-type nearest neighbor interactions. Simulation results are presented that demonstrate the role of small-world effects on the speed of consensus algorithms and cooperative control of multivehicle formations

9,715 citations


Journal ArticleDOI
TL;DR: The Shuttle Radar Topography Mission produced the most complete, highest-resolution digital elevation model of the Earth, using dual radar antennas to acquire interferometric radar data, processed to digital topographic data at 1 arc sec resolution.
Abstract: [1] The Shuttle Radar Topography Mission produced the most complete, highest-resolution digital elevation model of the Earth. The project was a joint endeavor of NASA, the National Geospatial-Intelligence Agency, and the German and Italian Space Agencies and flew in February 2000. It used dual radar antennas to acquire interferometric radar data, processed to digital topographic data at 1 arc sec resolution. Details of the development, flight operations, data processing, and products are provided for users of this revolutionary data set.

5,019 citations


Proceedings Article
03 Dec 2007
TL;DR: Two sets of random features are explored, provided convergence bounds on their ability to approximate various radial basis kernels, and it is shown that in large-scale classification and regression tasks linear machine learning algorithms applied to these features outperform state-of-the-art large- scale kernel machines.
Abstract: To accelerate the training of kernel machines, we propose to map the input data to a randomized low-dimensional feature space and then apply existing fast linear methods. The features are designed so that the inner products of the transformed data are approximately equal to those in the feature space of a user specified shift-invariant kernel. We explore two sets of random features, provide convergence bounds on their ability to approximate various radial basis kernels, and show that in large-scale classification and regression tasks linear machine learning algorithms applied to these features outperform state-of-the-art large-scale kernel machines.

3,405 citations


Journal ArticleDOI
08 Jun 2007-Science
TL;DR: A large-scale chromatin immunoprecipitation assay based on direct ultrahigh-throughput DNA sequencing was developed, which was then used to map in vivo binding of the neuron-restrictive silencer factor (NRSF; also known as REST) to 1946 locations in the human genome.
Abstract: In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To map these protein-DNA interactions comprehensively across entire mammalian genomes, we developed a large-scale chromatin immunoprecipitation assay (ChIPSeq) based on direct ultrahigh-throughput DNA sequencing. This sequence census method was then used to map in vivo binding of the neuron-restrictive silencer factor (NRSF; also known as REST, for repressor element–1 silencing transcription factor) to 1946 locations in the human genome. The data display sharp resolution of binding position [±50 base pairs (bp)], which facilitated our finding motifs and allowed us to identify noncanonical NRSF-binding motifs. These ChIPSeq data also have high sensitivity and specificity [ROC (receiver operator characteristic) area ≥ 0.96] and statistical confidence (P <10^(–4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development.

2,789 citations


Journal ArticleDOI
TL;DR: This letter addresses the problem of energy detection of an unknown signal over a multipath channel with the no-diversity case, and presents some alternative closed-form expressions for the probability of detection to those recently reported in the literature.
Abstract: This letter addresses the problem of energy detection of an unknown signal over a multipath channel. It starts with the no-diversity case, and presents some alternative closed-form expressions for the probability of detection to those recently reported in the literature. Detection capability is boosted by implementing both square-law combining and square-law selection diversity schemes

2,610 citations


Journal ArticleDOI
TL;DR: The incremental algorithm is compared experimentally to an earlier batch Bayesian algorithm, as well as to one based on maximum-likelihood, which have comparable classification performance on small training sets, but incremental learning is significantly faster, making real-time learning feasible.

2,597 citations


Journal ArticleDOI
TL;DR: It is shown that ‘1 minimization recovers x 0 exactly when the number of measurements exceeds m Const ·µ 2 (U) ·S · logn, where S is the numberof nonzero components in x 0, and µ is the largest entry in U properly normalized: µ(U) = p n · maxk,j |Uk,j|.
Abstract: We consider the problem of reconstructing a sparse signal x 0 2 R n from a limited number of linear measurements. Given m randomly selected samples of Ux 0 , where U is an orthonormal matrix, we show that ‘1 minimization recovers x 0 exactly when the number of measurements exceeds m Const ·µ 2 (U) ·S · logn, where S is the number of nonzero components in x 0 , and µ is the largest entry in U properly normalized: µ(U) = p n · maxk,j |Uk,j|. The smaller µ, the fewer samples needed. The result holds for “most” sparse signals x 0 supported on a fixed (but arbitrary) set T. Given T, if the sign of x 0 for each nonzero entry on T and the observed values of Ux 0 are drawn at random, the signal is recovered with overwhelming probability. Moreover, there is a sense in which this is nearly optimal since any method succeeding with the same probability would require just about this many samples.

2,187 citations


Journal ArticleDOI
09 Feb 2007-Science
TL;DR: New developments in nanotechnology, biotechnology, and the materials and physical sciences may enable step-change approaches to cost-effective, globally scalable systems for solar energy use.
Abstract: At present, solar energy conversion technologies face cost and scalability hurdles in the technologies required for a complete energy system. To provide a truly widespread primary energy source, solar energy must be captured, converted, and stored in a cost-effective fashion. New developments in nanotechnology, biotechnology, and the materials and physical sciences may enable step-change approaches to cost-effective, globally scalable systems for solar energy use.

2,113 citations


Journal ArticleDOI
TL;DR: Application of a selective Rho-associated kinase (ROCK) inhibitor, Y-27632, to hES cells markedly diminishes dissociation-induced apoptosis, increases cloning efficiency and facilitates subcloning after gene transfer, and enables SFEB-cultured hES Cells to survive and differentiate into Bf1+ cortical and basal telencephalic progenitors.
Abstract: Poor survival of human embryonic stem (hES) cells after cell dissociation is an obstacle to research, hindering manipulations such as subcloning. Here we show that application of a selective Rho-associated kinase (ROCK) inhibitor1,2, Y-27632, to hES cells markedly diminishes dissociation-induced apoptosis, increases cloning efficiency (from ∼1% to ∼27%) and facilitates subcloning after gene transfer. Furthermore, dissociated hES cells treated with Y-27632 are protected from apoptosis even in serum-free suspension (SFEB) culture3 and form floating aggregates. We demonstrate that the protective ability of Y-27632 enables SFEB-cultured hES cells to survive and differentiate into Bf1+ cortical and basal telencephalic progenitors, as do SFEB-cultured mouse ES cells.

2,094 citations


Journal ArticleDOI
TL;DR: In this paper, the authors analyzed star formation as a function of stellar mass (M☉) and redshift z in the All-Wavelength Extended Groth Strip International Survey.
Abstract: We analyze star formation (SF) as a function of stellar mass (M☉) and redshift z in the All-Wavelength Extended Groth Strip International Survey. For 2905 field galaxies, complete to 10^10(10^10.8 )M at z < 0.7(1), with Keck spectroscopic redshifts out to z = 1.1, we compile SF rates (SFRs) from emission lines, GALEX, and Spitzer MIPS 24 µm photometry, optical-NIR M* measurements, and HST morphologies. Galaxies with reliable signs of SF form a distinct “main sequence” (MS), with a limited range of SFRs at a given M* and z (1 σ ≾ ±0.3 dex), and log (SFR) approximately proportional to log M*. The range of log (SFR) remains constant to z > 1, while the MS as a whole moves to higher SFR as z increases. The range of the SFR along the MS constrains the amplitude of episodic variations of SF and the effect of mergers on the SFR. Typical galaxies spend ∼67%(95%) of their lifetime since z = 1 within a factor of ≾2(4) of their average SFR at a given M* and z. The dominant mode of the evolution of SF since z ∼ 1 is apparently a gradual decline of the average SFR in most individual galaxies, not a decreasing frequency of starburst episodes, or a decreasing factor by which SFRs are enhanced in starbursts. LIRGs at z ∼ 1 seem to mostly reflect the high SFR typical for massive galaxies at that epoch. The smooth MS may reflect that the same set of few physical processes governs SF prior to additional quenching processes. A gradual process like gas exhaustion may play a dominant role.

1,882 citations


Journal ArticleDOI
TL;DR: In this article, the authors used the HST data to trace the history of cosmic expansion over the last 10 billion years, and found 21 new Type Ia supernovae (SNe Ia) with the Hubble Space Telescope (HST).
Abstract: We have discovered 21 new Type Ia supernovae (SNe Ia) with the Hubble Space Telescope (HST) and have used them to trace the history of cosmic expansion over the last 10 billion yr. These objects, which include 13 spectroscopicallyconfirmedSNeIaat z � 1,werediscoveredduring14epochsofreimagingoftheGOODSfieldsNorthand South over 2 yr with the Advanced Camera for Surveys on HST. Together with a recalibration of our previous HSTdiscovered SNe Ia, the full sample of 23 SNe Ia at z � 1 provides the highest redshift sample known. Combining these data with previous SN Ia data sets, we measured Hz ðÞ at discrete, uncorrelated epochs, reducing the uncertainty of Hz >1 ðÞ from 50% to under 20%, strengthening the evidence for a cosmic jerk—the transition from deceleration in the past to acceleration in thepresent. The uniqueleverage of theHSThigh-redshift SNe Ia provides thefirstmeaningful constraint on the dark energy equation-of-state parameter at z � 1. The result remains consistent with a cosmological constant [ wz ðÞ ¼� 1] and rules out rapidly evolving dark energy (dw/dz 31). The defining property of dark energy, its negative pressure, appears to be present at z > 1, in the epoch preceding acceleration, with � 98% confidenceinourprimaryfit.Moreover,thez > 1sample-averagedspectralenergydistributionisconsistentwiththat of thetypicalSNIaoverthelast10Gyr,indicatingthatanyspectralevolutionofthepropertiesof SNeIawithredshift is still below our detection threshold.

Journal ArticleDOI
TL;DR: The Cosmic Evolution Survey (COSMOS) as mentioned in this paper is designed to probe the correlated evolution of galaxies, star formation, active galactic nuclei (AGNs), and dark matter (DM) with large-scale structure (LSS) over the redshift range z > 0.5-6.
Abstract: The Cosmic Evolution Survey (COSMOS) is designed to probe the correlated evolution of galaxies, star formation, active galactic nuclei (AGNs), and dark matter (DM) with large-scale structure (LSS) over the redshift range z > 0.5-6. The survey includes multiwavelength imaging and spectroscopy from X-ray-to-radio wavelengths covering a 2 deg^2 area, including HST imaging. Given the very high sensitivity and resolution of these data sets, COSMOS also provides unprecedented samples of objects at high redshift with greatly reduced cosmic variance, compared to earlier surveys. Here we provide a brief overview of the survey strategy, the characteristics of the major COSMOS data sets, and a summary the science goals.

Journal ArticleDOI
TL;DR: This study uses microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboinosinic:polyribocytidylic acid or the cytokine IFN-β and characterize miR-155 as a common target of a broad range of inflammatory mediators.
Abstract: The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences of unregulated expression, such as cancer. Recently, microRNAs (miRNAs) have emerged as a class of gene expression regulators that has also been linked to cancer. However, the relationship between inflammation, innate immunity, and miRNA expression is just beginning to be explored. In the present study, we use microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboinosinic:polyribocytidylic acid or the cytokine IFN-β. miR-155 was the only miRNA of those tested that was substantially up-regulated by both stimuli. It also was induced by several Toll-like receptor ligands through myeloid differentiation factor 88- or TRIF-dependent pathways, whereas up-regulation by IFNs was shown to involve TNF-α autocrine signaling. Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-α, suggesting that miR-155-inducing signals use the JNK pathway. Together, these findings characterize miR-155 as a common target of a broad range of inflammatory mediators. Importantly, because miR-155 is known to function as an oncogene, these observations identify a potential link between inflammation and cancer.

Journal ArticleDOI
TL;DR: In this paper, the authors studied the relationship between the local environment of galaxies and their star formation rate (SFR) in the Great Observatories Origins Deep Survey, GOODS, at z∼1.
Abstract: Aims We study the relationship between the local environment of galaxies and their star formation rate (SFR) in the Great Observatories Origins Deep Survey, GOODS, at z∼1 Methods We use ultradeep imaging at 24� m with the MIPS camera onboard Spitzer to determine the contribution of obscured light to the SFR of galaxies over the redshift range 08≤ z ≤12 Accurate galaxy densities are measured thanks to the large sample of ∼1200 spectroscopic redshifts with high (∼70 %) spectroscopic completeness Morphology and stellar masses are derived from deep HST-ACS imaging, supplemented by ground based imaging programs and photometry from the IRAC camera onboard Spitzer Results We show that the star formation‐density relation observed locally was reversed at z∼ 1: the average SFR of an individual galaxy increased with local galaxy density when the universe was less than half its present age Hierarchical galaxy for mation models (simulated lightcones from the Millennium model) predicted such a reversal to occur only at earlier epochs (z>2) and at a lower level We present a remarkable structure at z∼ 1016, containing X-ray traced galaxy concentrations, which will eventually merge into a Virgo-like cluster This structure illustrates how the ind ividual SFR of galaxies increases with density and shows that it is the∼1‐2 Mpc scale that affects most the star formation in galaxies at z∼ 1 The SFR of z∼ 1 galaxies is found to correlate with stellar mass suggesting that mass plays a role in the observed star formation‐density trend However the specific SFR ( =SFR/M⋆) decreases with stellar mass while it increases with galaxy density, which i mplies that the environment does directly affect the star formation activity of galaxies Major mergers do not appear to be the unique or even major cause for this effect since nearly half (46 %) of the luminous infrared galaxies (LIRGs) at z∼ 1 present the HST-ACS morphology of spirals, while only a third present a clear signature of major mergers The remaining galaxies are divided into compact (9 %) and irregular (14 %) galaxies Moreover, the specific SFR o f major mergers is only marginally stronger than that of spirals Conclusions These findings constrain the influence of the growth of large- scale structures on the star formation history of galaxies Reproducing the SFR‐density relation at z∼ 1 is a new challenge for models, requiring a correct balance between mass assembly through mergers and in-situ star formation at early epochs

Journal ArticleDOI
TL;DR: In this article, the authors measured star formation rates (SFRs) of 50,000 optically selected galaxies in the local universe (z ≈ 0.1) by fitting the GALEX (ultraviolet) and SDSS photometry to a library of dustattenuated population synthesis models.
Abstract: We measure star formation rates (SFRs) of ≈50,000 optically selected galaxies in the local universe (z ≈ 0.1)—from gas-rich dwarfs to massive ellipticals. We obtain dust-corrected SFRs by fitting the GALEX (ultraviolet) and SDSS photometry to a library of dust-attenuated population synthesis models. For star-forming galaxies, our UV-based SFRs compare remarkably well with those from SDSS-measured emission lines (Hα). Deviations from perfect agreement are shown to be due to differences in the dust attenuation estimates. In contrast to Hα measurements, UV provides reliable SFRs for galaxies with weak Hα, and where Hα is contaminated with AGN emission (1/2 of the sample). Using full-SED SFRs, we calibrate a simple prescription that uses GALEX far- and near-UV magnitudes to produce dust-corrected SFRs for normal star-forming galaxies. The specific SFR is considered as a function of stellar mass for (1) star-forming galaxies with no AGNs, (2) those hosting an AGN, and (3) galaxies without Hα emission. We find that the three have distinct star formation histories, with AGNs lying intermediate between the star-forming and the quiescent galaxies. Star-forming galaxies without an AGN lie on a relatively narrow linear sequence. Remarkably, galaxies hosting a strong AGN appear to represent the massive continuation of this sequence. On the other hand, weak AGNs, while also massive, have lower SFRs, sometimes extending to the realm of quiescent galaxies. We propose an evolutionary sequence for massive galaxies that smoothly connects normal star-forming galaxies to quiescent galaxies via strong and weak AGNs. We confirm that some galaxies with no Hα show signs of star formation in the UV. We derive a cosmic star formation density at z = 0.1 with significantly smaller total error than previous measurements.

Journal ArticleDOI
TL;DR: In this article, the authors examined a sample of massive galaxies at 1.4 10 11 L and showed a mid-IR excess which is likely due to the presence of obscured active nuclei, as shown in a companion paper.
Abstract: Examining a sample of massive galaxies at 1.4 10 11 L⊙, show a mid-IR excess which is likely due to the presence of obscured active nuclei, as shown in a companion paper. There is a tight and roughly linear correlation between stellar mass and SFR for 24µm-detected galaxies. For a given mass, the SFR at z = 2 was larger by a factor of ∼ 4 and ∼ 30 relative to that in star forming galaxies at z = 1 and z = 0, respectively. Typical ultraluminous infrared galaxies (ULIRGs) at z = 2 are relatively ’transparent’ to ultraviolet light, and their activity is long lived ( > ∼ 400 Myr), unlike that in local ULIRGs and high redshift submillimeter-selected galaxies. ULIRGs are the common mode of star formation in massive galaxies at z = 2, and the high duty cycle suggests that major mergers are not the dominant trigger for this activity. Current galaxy formation models underpredict the normalization of the mass-SFR correlation by about a factor of 4, and the space density of ULIRGs by an order of magnitude, but give better agreement for z > 1.4 quiescent galaxies. Subject headings: galaxies: evolution — galaxies: formation — cosmology: observations — galaxies: starbursts — galaxies: high-redshift

Journal ArticleDOI
TL;DR: It is shown that the cytokine interleukin-6 (IL-6) is critical for mediating the behavioral and transcriptional changes in the offspring and should be identified as a key intermediary in the molecular dissection of the pathways whereby MIA alters fetal brain development.
Abstract: Schizophrenia and autism are thought to result from the interaction between a susceptibility genotype and environmental risk factors. The offspring of women who experience infection while pregnant have an increased risk for these disorders. Maternal immune activation (MIA) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism, making MIA a useful model of the disorders. However, the mechanism by which MIA causes long-term behavioral deficits in the offspring is unknown. Here we show that the cytokine interleukin-6 (IL-6) is critical for mediating the behavioral and transcriptional changes in the offspring. A single maternal injection of IL-6 on day 12.5 of mouse pregnancy causes prepulse inhibition (PPI) and latent inhibition (LI) deficits in the adult offspring. Moreover, coadministration of an anti-IL-6 antibody in the poly(I:C) model of MIA prevents the PPI, LI, and exploratory and social deficits caused by poly(I:C) and normalizes the associated changes in gene expression in the brains of adult offspring. Finally, MIA in IL-6 knock-out mice does not result in several of the behavioral changes seen in the offspring of wild-type mice after MIA. The identification of IL-6 as a key intermediary should aid in the molecular dissection of the pathways whereby MIA alters fetal brain development, which can shed new light on the pathophysiological mechanisms that predispose to schizophrenia and autism.

Journal ArticleDOI
19 Apr 2007-Nature
TL;DR: It is shown that six patients with focal bilateral damage to the ventromedial prefrontal cortex (VMPC), a brain region necessary for the normal generation of emotions, produce an abnormally ‘utilitarian’ pattern of judgements on moral dilemmas that pit compelling considerations of aggregate welfare against highly emotionally aversive behaviours.
Abstract: The psychological and neurobiological processes underlying moral judgement have been the focus of many recent empirical studies. Of central interest is whether emotions play a causal role in moral judgement, and, in parallel, how emotion-related areas of the brain contribute to moral judgement. Here we show that six patients with focal bilateral damage to the ventromedial prefrontal cortex (VMPC), a brain region necessary for the normal generation of emotions and, in particular, social emotions, produce an abnormally 'utilitarian' pattern of judgements on moral dilemmas that pit compelling considerations of aggregate welfare against highly emotionally aversive behaviours (for example, having to sacrifice one person's life to save a number of other lives). In contrast, the VMPC patients' judgements were normal in other classes of moral dilemmas. These findings indicate that, for a selective set of moral dilemmas, the VMPC is critical for normal judgements of right and wrong. The findings support a necessary role for emotion in the generation of those judgements.

Journal ArticleDOI
05 Mar 2007
TL;DR: A survey of the recent efforts towards a systematic understanding of layering as optimization decomposition can be found in this paper, where the overall communication network is modeled by a generalized network utility maximization problem, each layer corresponds to a decomposed subproblem, and the interfaces among layers are quantified as functions of the optimization variables coordinating the subproblems.
Abstract: Network protocols in layered architectures have historically been obtained on an ad hoc basis, and many of the recent cross-layer designs are also conducted through piecemeal approaches. Network protocol stacks may instead be holistically analyzed and systematically designed as distributed solutions to some global optimization problems. This paper presents a survey of the recent efforts towards a systematic understanding of layering as optimization decomposition, where the overall communication network is modeled by a generalized network utility maximization problem, each layer corresponds to a decomposed subproblem, and the interfaces among layers are quantified as functions of the optimization variables coordinating the subproblems. There can be many alternative decompositions, leading to a choice of different layering architectures. This paper surveys the current status of horizontal decomposition into distributed computation, and vertical decomposition into functional modules such as congestion control, routing, scheduling, random access, power control, and channel coding. Key messages and methods arising from many recent works are summarized, and open issues discussed. Through case studies, it is illustrated how layering as Optimization Decomposition provides a common language to think about modularization in the face of complex, networked interactions, a unifying, top-down approach to design protocol stacks, and a mathematical theory of network architectures

Journal ArticleDOI
22 Nov 2007-Nature
TL;DR: In this article, a metagenomic analysis of the bacterial community resident in the hindgut paunch of a wood-feeding Nasutitermes species (which do not contain cellulose-fermenting protozoa) was performed to show the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis.
Abstract: From the standpoints of both basic research and biotechnology, there is considerable interest in reaching a clearer understanding of the diversity of biological mechanisms employed during lignocellulose degradation. Globally, termites are an extremely successful group of wood-degrading organisms and are therefore important both for their roles in carbon turnover in the environment and as potential sources of biochemical catalysts for efforts aimed at converting wood into biofuels. Only recently have data supported any direct role for the symbiotic bacteria in the gut of the termite in cellulose and xylan hydrolysis. Here we use a metagenomic analysis of the bacterial community resident in the hindgut paunch of a wood-feeding ‘higher’ Nasutitermes species (which do not contain cellulose-fermenting protozoa) to show the presence of a large, diverse set of bacterial genes for cellulose and xylan hydrolysis. Many of these genes were expressed in vivo or had cellulase activity in vitro, and further analyses implicate spirochete and fibrobacter species in gut lignocellulose degradation. New insights into other important symbiotic functions including H_2 metabolism, CO_2-reductive acetogenesis and N_2 fixation are also provided by this first system-wide gene analysis of a microbial community specialized towards plant lignocellulose degradation. Our results underscore how complex even a 1-μl environment can be.

Journal ArticleDOI
TL;DR: A review of living ring-opening metathesis polymerization (ROMP) reactions can be found in this article, along with a discussion of state-of-the-art catalysts for use in living ROMP reactions as well as opportunities for the future.

Journal ArticleDOI
TL;DR: The molecular mechanisms that control mitochondrial dynamics, and why are they important for mitochondrial function are reviewed and how defects in mitochondrial dynamics might cause neuronal disease is explored.
Abstract: Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are actively transported to specific subcellular locations. These dynamic processes are essential for mammalian development, and defects lead to neurodegenerative disease. But what are the molecular mechanisms that control mitochondrial dynamics, and why are they important for mitochondrial function? We review these issues and explore how defects in mitochondrial dynamics might cause neuronal disease.

Journal ArticleDOI
10 Aug 2007-Science
TL;DR: A highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 108) whispering-gallery microcavity is reported and label-free, single-molecule detection of interleukin-2 was demonstrated in serum.
Abstract: Current single-molecule detection techniques require labeling the target molecule. We report a highly specific and sensitive optical sensor based on an ultrahigh quality (Q) factor (Q > 10^8) whispering-gallery microcavity. The silica surface is functionalized to bind the target molecule; binding is detected by a resonant wavelength shift. Single-molecule detection is confirmed by observation of single-molecule binding events that shift the resonant frequency, as well as by the statistics for these shifts over many binding events. These shifts result from a thermo-optic mechanism. Additionally, label-free, single-molecule detection of interleukin-2 was demonstrated in serum. These experiments demonstrate a dynamic range of 10^(12) in concentration, establishing the microcavity as a sensitive and versatile detector.

Journal ArticleDOI
TL;DR: The problem of finding the (symmetric) edge weights that result in the least mean-square deviation in steady state is considered and it is shown that this problem can be cast as a convex optimization problem, so the global solution can be found efficiently.

Journal ArticleDOI
TL;DR: Galaxy Evolution Explorer (GALEX) data releases have identical pipeline calibrations that are significantly improved over the GR1 data release, achieving photometric repeatability of 0.05 and 0.03 m(AB) in the FUV and NUV, respectively as mentioned in this paper.
Abstract: We describe the calibration status and data products pertaining to the GR2 and GR3 data releases of the Galaxy Evolution Explorer (GALEX). These releases have identical pipeline calibrations that are significantly improved over the GR1 data release. GALEX continues to survey the sky in the far-ultraviolet (FUV, ~154 nm) and near-ultraviolet (NUV, ~232 nm) bands, providing simultaneous imaging with a pair of photon-counting, microchannel plate, delay line readout detectors. These 1.25° field of view detectors are well suited to ultraviolet observations because of their excellent red rejection and negligible background. A dithered mode of observing and photon list output pose complex requirements on the data processing pipeline, entangling detector calibrations, and aspect reconstruction algorithms. Recent improvements have achieved photometric repeatability of 0.05 and 0.03 m_(AB) in the FUV and NUV, respectively. We have detected a long-term drift of order 1% FUV and 6% NUV over the mission. Astrometric precision is of order 0.5" rms in both bands. In this paper we provide the GALEX user with a broad overview of the calibration issues likely to be confronted in the current release. Improvements are likely as the GALEX mission continues into an extended phase with a healthy instrument, no consumables, and increased opportunities for guest investigations.

Journal ArticleDOI
TL;DR: In this paper, the authors make a number of conjectures about the geometry of continuous moduli parameterizing the string landscape, including that such moduli are always given by expectation value of scalar fields and that moduli spaces with finite non-zero diameter belong to the swampland.

Journal ArticleDOI
25 Jan 2007-Nature
TL;DR: A 160,000-bit molecular electronic memory circuit, fabricated at a density of 1011 bits cm-2 (pitch 33 nm; memory cell size 0.0011 μm2), that is, roughly analogous to the dimensions of a DRAM circuit projected to be available by 2020.
Abstract: The primary metric for gauging progress in the various semiconductor integrated circuit technologies is the spacing, or pitch, between the most closely spaced wires within a dynamic random access memory (DRAM) circuit. Modern DRAM circuits have 140 nm pitch wires and a memory cell size of 0.0408 mum(2). Improving integrated circuit technology will require that these dimensions decrease over time. However, at present a large fraction of the patterning and materials requirements that we expect to need for the construction of new integrated circuit technologies in 2013 have 'no known solution'. Promising ingredients for advances in integrated circuit technology are nanowires, molecular electronics and defect-tolerant architectures, as demonstrated by reports of single devices and small circuits. Methods of extending these approaches to large-scale, high-density circuitry are largely undeveloped. Here we describe a 160,000-bit molecular electronic memory circuit, fabricated at a density of 10(11) bits cm(-2) (pitch 33 nm; memory cell size 0.0011 microm2), that is, roughly analogous to the dimensions of a DRAM circuit projected to be available by 2020. A monolayer of bistable, [2]rotaxane molecules served as the data storage elements. Although the circuit has large numbers of defects, those defects could be readily identified through electronic testing and isolated using software coding. The working bits were then configured to form a fully functional random access memory circuit for storing and retrieving information.

Journal ArticleDOI
TL;DR: Physical dust models for 65 galaxies in SINGS that are strongly detected in the four IRAC bands and three MIPS bands were presented for each galaxy as discussed by the authors, estimating the total dust mass, the fraction of the dust mass contributed by PAHs, and the intensity of the starlight heating the dust grains.
Abstract: Physical dust models are presented for 65 galaxies in SINGS that are strongly detected in the four IRAC bands and three MIPS bands. For each galaxy we estimate (1) the total dust mass, (2) the fraction of the dust mass contributed by PAHs, and (3) the intensity of the starlight heating the dust grains. We find that spiral galaxies have dust properties resembling the dust in the local region of the Milky Way, with similar dust-to-gas ratio and similar PAH abundance. The observed SEDs, including galaxies with SCUBA photometry, can be reproduced by dust models that do not require "cold" (T ≾ 10 K) dust. The dust-to-gas ratio is observed to be dependent on metallicity. In the interstellar media of galaxies with A_O ≡ 12 + log_(10)(O/H) > 8.1, grains contain a substantial fraction of interstellar Mg, Si, and Fe. Galaxies with A_O 8.1 have a median q_(PAH) = 3.55%. The derived dust masses favor a value X_(CO) ≈ 4 × 10^(20) cm^(-2) (K km s^(-1))^(-1) for the CO-to-H_2 conversion factor. Except for some starbursting systems (Mrk 33, Tol 89, NGC 3049), dust in the diffuse ISM dominates the IR power.

Journal ArticleDOI
TL;DR: In this paper, the information retrieval from evaporating black holes is studied under the assumption that the internal dynamics of a black hole is unitary and rapidly mixing, and assuming that the retriever has unlimited control over the emitted Hawking radiation.
Abstract: We study information retrieval from evaporating black holes, assuming that the internal dynamics of a black hole is unitary and rapidly mixing, and assuming that the retriever has unlimited control over the emitted Hawking radiation. If the evaporation of the black hole has already proceeded past the ``half-way'' point, where half of the initial entropy has been radiated away, then additional quantum information deposited in the black hole is revealed in the Hawking radiation very rapidly. Information deposited prior to the half-way point remains concealed until the half-way point, and then emerges quickly. These conclusions hold because typical local quantum circuits are efficient encoders for quantum error-correcting codes that nearly achieve the capacity of the quantum erasure channel. Our estimate of a black hole's information retention time, based on speculative dynamical assumptions, is just barely compatible with the black hole complementarity hypothesis.

Journal ArticleDOI
TL;DR: The fabrication and operation of self-sensing nanocantilevers with fundamental mechanical resonances up to very high frequencies (VHF) are described, enabling applications requiring previously inaccessible sensitivity and bandwidth, such as fast SPM and VHF force sensing.
Abstract: Ultra-sensitive NEMS-based cantilevers for sensing, scanned probe and very high-frequency applications