California Institute of Technology

About: California Institute of Technology is a education organization based out in Pasadena, California, United States. It is known for research contribution in the topics: Galaxy & Redshift. The organization has 57649 authors who have published 146691 publications receiving 8620287 citations. The organization is also known as: Caltech & Cal Tech.

Fluorescence detection in automated DNA sequence analysis

Abstract: We have developed a method for the partial automation of DNA sequence analysis. Fluorescence detection of the DNA fragments is accomplished by means of a fluorophore covalently attached to the oligonucleotide primer used in enzymatic DNA sequence analysis. A different coloured fluorophore is used for each of the reactions specific for the bases A, C, G and T. The reaction mixtures are combined and co-electrophoresed down a single polyacrylamide gel tube, the separated fluorescent bands of DNA are detected near the bottom of the tube, and the sequence information is acquired directly by computer.

Neuromorphic electronic systems

Abstract: It is shown that for many problems, particularly those in which the input data are ill-conditioned and the computation can be specified in a relative manner, biological solutions are many orders of magnitude more effective than those using digital methods. This advantage can be attributed principally to the use of elementary physical phenomena as computational primitives, and to the representation of information by the relative values of analog signals rather than by the absolute values of digital signals. This approach requires adaptive techniques to mitigate the effects of component differences. This kind of adaptation leads naturally to systems that learn about their environment. Large-scale adaptive analog systems are more robust to component degradation and failure than are more conventional systems, and they use far less power. For this reason, adaptive analog technology can be expected to utilize the full potential of wafer-scale silicon fabrication. >

Nonholonomic motion planning: steering using sinusoids

Abstract: Methods for steering systems with nonholonomic c.onstraints between arbitrary configurations are investigated. Suboptimal trajectories are derived for systems that are not in canonical form. Systems in which it takes more than one level of bracketing to achieve controllability are considered. The trajectories use sinusoids at integrally related frequencies to achieve motion at a given bracketing level. A class of systems that can be steered using sinusoids (claimed systems) is defined. Conditions under which a class of two-input systems can be converted into this form are given. >

The Hubble Space Telescope Cluster Supernova Survey. V. Improving the Dark-energy Constraints above z > 1 and Building an Early-type-hosted Supernova Sample

Abstract: We present Advanced Camera for Surveys, NICMOS, and Keck adaptive-optics-assisted photometry of 20 Type Ia supernovae (SNe Ia) from the Hubble Space Telescope (HST) Cluster Supernova Survey. The SNe Ia were discovered over the redshift interval 0.623 1 SNe Ia. We describe how such a sample could be efficiently obtained by targeting cluster fields with WFC3 on board HST. The updated supernova Union2.1 compilation of 580 SNe is available at http://supernova.lbl.gov/Union.