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Canadian Real Estate Association

About: Canadian Real Estate Association is a based out in . It is known for research contribution in the topics: Population & Thermal energy storage. The organization has 2279 authors who have published 4014 publications receiving 79321 citations.

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Journal ArticleDOI
TL;DR: In this paper, a review of the history of thermal energy storage with solid-liquid phase change has been carried out and three aspects have been the focus of this review: materials, heat transfer and applications.
Abstract: Thermal energy storage in general, and phase change materials (PCMs) in particular, have been a main topic in research for the last 20 years, but although the information is quantitatively enormous, it is also spread widely in the literature, and difficult to find. In this work, a review has been carried out of the history of thermal energy storage with solid–liquid phase change. Three aspects have been the focus of this review: materials, heat transfer and applications. The paper contains listed over 150 materials used in research as PCMs, and about 45 commercially available PCMs. The paper lists over 230 references.

4,019 citations

Journal ArticleDOI
Bin Zhou1, Yuan Lu2, Kaveh Hajifathalian2, James Bentham1  +494 moreInstitutions (170)
TL;DR: In this article, the authors used a Bayesian hierarchical model to estimate trends in diabetes prevalence, defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs in 200 countries and territories in 21 regions, by sex and from 1980 to 2014.
Abstract: Background: One of the global targets for non-communicable diseases is to halt, by 2025, the rise in the age standardised adult prevalence of diabetes at its 2010 levels. We aimed to estimate worldwide trends in diabetes, how likely it is for countries to achieve the global target, and how changes in prevalence, together with population growth and ageing, are aff ecting the number of adults with diabetes. Methods: We pooled data from population-based studies that had collected data on diabetes through measurement of its biomarkers. We used a Bayesian hierarchical model to estimate trends in diabetes prevalence-defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs-in 200 countries and territories in 21 regions, by sex and from 1980 to 2014. We also calculated the posterior probability of meeting the global diabetes target if post-2000 trends continue. Findings: We used data from 751 studies including 4372000 adults from 146 of the 200 countries we make estimates for. Global age-standardised diabetes prevalence increased from 4.3% (95% credible interval 2.4-17.0) in 1980 to 9.0% (7.2-11.1) in 2014 in men, and from 5.0% (2.9-7.9) to 7.9% (6.4-9.7) in women. The number of adults with diabetes in the world increased from 108 million in 1980 to 422 million in 2014 (28.5% due to the rise in prevalence, 39.7% due to population growth and ageing, and 31.8% due to interaction of these two factors). Age-standardised adult diabetes prevalence in 2014 was lowest in northwestern Europe, and highest in Polynesia and Micronesia, at nearly 25%, followed by Melanesia and the Middle East and north Africa. Between 1980 and 2014 there was little change in age-standardised diabetes prevalence in adult women in continental western Europe, although crude prevalence rose because of ageing of the population. By contrast, age-standardised adult prevalence rose by 15 percentage points in men and women in Polynesia and Micronesia. In 2014, American Samoa had the highest national prevalence of diabetes (>30% in both sexes), with age-standardised adult prevalence also higher than 25% in some other islands in Polynesia and Micronesia. If post-2000 trends continue, the probability of meeting the global target of halting the rise in the prevalence of diabetes by 2025 at the 2010 level worldwide is lower than 1% for men and is 1% for women. Only nine countries for men and 29 countries for women, mostly in western Europe, have a 50% or higher probability of meeting the global target. Interpretation: Since 1980, age-standardised diabetes prevalence in adults has increased, or at best remained unchanged, in every country. Together with population growth and ageing, this rise has led to a near quadrupling of the number of adults with diabetes worldwide. The burden of diabetes, both in terms of prevalence and number of adults aff ected, has increased faster in low-income and middle-income countries than in high-income countries.

2,782 citations

Journal ArticleDOI
Rudi Appels1, Rudi Appels2, Kellye Eversole, Nils Stein3  +204 moreInstitutions (45)
17 Aug 2018-Science
TL;DR: This annotated reference sequence of wheat is a resource that can now drive disruptive innovation in wheat improvement, as this community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.
Abstract: An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

2,118 citations

Journal ArticleDOI
Paul Bastard1, Paul Bastard2, Paul Bastard3, Lindsey B. Rosen4, Qian Zhang2, Eleftherios Michailidis2, Hans-Heinrich Hoffmann2, Yu Zhang4, Karim Dorgham1, Quentin Philippot1, Quentin Philippot3, Jérémie Rosain1, Jérémie Rosain3, Vivien Béziat2, Vivien Béziat1, Vivien Béziat3, Jeremy Manry3, Jeremy Manry1, Elana Shaw4, Liis Haljasmägi5, Pärt Peterson5, Lazaro Lorenzo3, Lazaro Lorenzo1, Lucy Bizien3, Lucy Bizien1, Sophie Trouillet-Assant6, Kerry Dobbs4, Adriana Almeida de Jesus4, Alexandre Belot6, Anne Kallaste7, Emilie Catherinot, Yacine Tandjaoui-Lambiotte3, Jérémie Le Pen2, Gaspard Kerner3, Gaspard Kerner1, Benedetta Bigio2, Yoann Seeleuthner1, Yoann Seeleuthner3, Rui Yang2, Alexandre Bolze, András N Spaan2, András N Spaan8, Ottavia M. Delmonte4, Michael S. Abers4, Alessandro Aiuti9, Giorgio Casari9, Vito Lampasona9, Lorenzo Piemonti9, Fabio Ciceri9, Kaya Bilguvar10, Richard P. Lifton10, Richard P. Lifton2, Marc Vasse, David M. Smadja1, Mélanie Migaud3, Mélanie Migaud1, Jérôme Hadjadj1, Benjamin Terrier1, Darragh Duffy11, Lluis Quintana-Murci11, Lluis Quintana-Murci12, Diederik van de Beek13, Lucie Roussel14, Donald C. Vinh14, Stuart G. Tangye15, Stuart G. Tangye16, Filomeen Haerynck17, David Dalmau18, Javier Martinez-Picado19, Javier Martinez-Picado20, Petter Brodin21, Petter Brodin22, Michel C. Nussenzweig2, Michel C. Nussenzweig23, Stéphanie Boisson-Dupuis2, Stéphanie Boisson-Dupuis1, Stéphanie Boisson-Dupuis3, Carlos Rodríguez-Gallego, Guillaume Vogt1, Trine H. Mogensen24, Trine H. Mogensen25, Andrew J. Oler4, Jingwen Gu4, Peter D. Burbelo4, Jeffrey I. Cohen4, Andrea Biondi26, Laura Rachele Bettini26, Mariella D'Angiò26, Paolo Bonfanti26, Patrick Rossignol27, Julien Mayaux1, Frédéric Rieux-Laucat1, Eystein S. Husebye28, Eystein S. Husebye29, Eystein S. Husebye30, Francesca Fusco, Matilde Valeria Ursini, Luisa Imberti31, Alessandra Sottini31, Simone Paghera31, Eugenia Quiros-Roldan32, Camillo Rossi, Riccardo Castagnoli33, Daniela Montagna33, Amelia Licari33, Gian Luigi Marseglia33, Xavier Duval, Jade Ghosn1, Hgid Lab4, Covid Clinicians5, Covid-Storm Clinicians§4, CoV-Contact Cohort§1, Amsterdam Umc Covid Biobank3, Amsterdam Umc Covid Biobank1, Amsterdam Umc Covid Biobank2, Covid Human Genetic Effort2, John S. Tsang4, Raphaela Goldbach-Mansky4, Kai Kisand5, Michail S. Lionakis4, Anne Puel2, Anne Puel3, Anne Puel1, Shen-Ying Zhang3, Shen-Ying Zhang2, Shen-Ying Zhang1, Steven M. Holland4, Guy Gorochov1, Emmanuelle Jouanguy3, Emmanuelle Jouanguy2, Emmanuelle Jouanguy1, Charles M. Rice2, Aurélie Cobat3, Aurélie Cobat2, Aurélie Cobat1, Luigi D. Notarangelo4, Laurent Abel2, Laurent Abel3, Laurent Abel1, Helen C. Su4, Jean-Laurent Casanova 
23 Oct 2020-Science
TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.
Abstract: Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

1,913 citations

Journal ArticleDOI
Qian Zhang1, Paul Bastard2, Paul Bastard3, Zhiyong Liu1  +169 moreInstitutions (34)
23 Oct 2020-Science
TL;DR: The COVID Human Genetic Effort established to test the general hypothesis that life-threatening COVID-19 in some or most patients may be caused by monogenic inborn errors of immunity to SARS-CoV-2 with incomplete or complete penetrance finds an enrichment in variants predicted to be loss-of-function (pLOF), with a minor allele frequency <0.001.
Abstract: Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection. By testing these and other rare variants at these 13 loci, we experimentally defined LOF variants underlying autosomal-recessive or autosomal-dominant deficiencies in 23 patients (3.5%) 17 to 77 years of age. We show that human fibroblasts with mutations affecting this circuit are vulnerable to SARS-CoV-2. Inborn errors of TLR3- and IRF7-dependent type I IFN immunity can underlie life-threatening COVID-19 pneumonia in patients with no prior severe infection.

1,659 citations


Showing all 2279 results

Diego F. Torres13794872180
Filippo Crea90111146264
Jacques-François Thisse8053129570
Nigel G. Yoccoz7834524044
Luisa F. Cabeza7654929134
Juan-Manuel Anaya7043817483
Francisco J. Varela6617939129
Riccardo Velasco6122613306
Luca Salvati5956710765
Robert I. Handin5914010434
Luigi Cattivelli5724614921
Aldo M. Roccaro552539512
J. Rico5412611569
Mauro Serafini5324613258
Claudio Tondo5230511707
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