Showing papers by "Cancer Epidemiology Unit published in 1987"
TL;DR: A multicentre retrospective cohort study of long-term survivors of childhood and adolescent cancer identified 7 cases of cancer among 2308 offspring of 2283 case-survivors and 11 cases among 4719 offspring of 3604 controls, but no excess was observed.
110 citations
TL;DR: Out of the 13 cases of mesothelioma, 6 were textile workers and 5 of these were "rag-sorters", there were only 5 textile workers among the 52 controls.
Abstract: By means of a review of histological diagnosis in the Pathology Department of the University of Florence, suspected cases of malignant mesothelioma, diagnosed in the period 1979-1984, were identified. Study of histological specimens permitted the selection of 13 cases of malignant mesothelioma resident in the Province of Florence. To these cases, referents were matched for age, sex, and year of hospital admission, with residence weighted for the general population of the Province. Both cases and referents (or their next of kin) completed an occupational questionnaire detailing possible occupational exposures. Out of the 13 cases of mesothelioma, 6 were textile workers and 5 of these were rag-sorters. There were only 5 textile workers among the 52 controls. No asbestos cloth production plants have been in operation in the area from which the cases and referents are derived. Possible sources of exposure to asbestos in the textile industry of this area are discussed.
20 citations
Journal Article•
TL;DR: The evidence for fat as a cause of breast cancer seems to have been exaggerated, and insufficient attention given to alternative explanations for the geographical correlations and for the changes among the Japanese in the frequency of the disease.
Abstract: Breast cancer mortality and incidence in different countries show a strongly positive correlation with the per caput consumption of fat. In addition, the disease has increased among the Japanese, both in Japan and in the United States, and in both groups fat consumption has been increasing. In contrast, both case-control and prospective studies have on the whole failed to confirm the relationship. Despite these negative findings, the hypothesis that fat causes breast cancer has continued to be popular. The evidence for fat as a cause of breast cancer seems to have been exaggerated, and insufficient attention given to alternative explanations for the geographical correlations and for the changes among the Japanese in the frequency of the disease. These include the effects on breast cancer risk of body weight, body size, age at menarche (all influenced by excess calories) and age at the birth of the first child, as well as effects of obesity on the fatality rate in breast cancer. Evidence is lacking that the source of calories is important.
8 citations
TL;DR: The hypothesis that a probable risk of lung cancer in textile workers in the Prato area was related to asbestos exposure is supported and is maintained in selected jobs in the textile industry.
Abstract: A case series in the Province of Florence showed an increased risk of mesothelioma in textile workers (nonasbestos) and a survey of working conditions confirmed potential exposure to asbestos. In order to investigate the risk in textile workers, including some specific job titles, a case-referent study on lung tumors was carried out. The lung cancer cases included 441 males with histologically confirmed primary lung cancer during the period 1980-1983. Referents included 1,075 males selected from two hospitals and matched for age, sex, and smoking habits. Those who had ''ever worked'' in the textile industry showed an adjusted odds ratio of 1.52 (95% C.I. 1-2.25) compared with other ''industrial workers.'' This moderately increased risk is maintained in selected jobs in the textile industry. An analysis of the modifying effect of time factors showed an increased risk in the period of 15-35 years from the date of first employment in the industry. The results support the hypothesis that a probable risk of lung cancer in textile workers in the Prato area was related to asbestos exposure.
4 citations