Institution
Cancer Epidemiology Unit
About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.
Topics: Population, Cancer, Breast cancer, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study
Papers published on a yearly basis
Papers
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TL;DR: This study implies that the relatively low BMI of vegetarians and vegans does cause small changes in SHBG and in post-menopausal oestradiol, but that the composition of vegetarian diets may not have any additional effects on these hormones.
Abstract: Endogenous oestradiol is strongly associated with breast cancer risk but its determinants are poorly understood. To test the hypothesis that vegetarians have lower plasma oestradiol and higher sex hormone-binding globulin (SHBG) than meat-eaters we assayed samples from 640 premenopausal women (153 meat-eaters, 382 vegetarians, 105 vegans) and 457 post-menopausal women (223 meat-eaters, 196 vegetarians, 38 vegans). Vegetarians and vegans had lower mean body mass indices (BMI) and lower plasma cholesterol concentrations than meat-eaters, but there were no statistically significant differences between meat-eaters, vegetarians and vegans in pre- or post-menopausal plasma concentrations of oestradiol or SHBG. Before adjusting for BMI there were small differences in the direction expected, with the vegetarians and vegans having higher SHBG and lower oestradiol (more noticeable amongst post-menopausal women) than the meat-eaters. These small differences were essentially eliminated by adjusting for BMI. Thus this study implies that the relatively low BMI of vegetarians and vegans does cause small changes in SHBG and in post-menopausal oestradiol, but that the composition of vegetarian diets may not have any additional effects on these hormones.
56 citations
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TL;DR: A favourable pattern in colorectal cancer mortality for both genders was observed in most European countries from the 1990s onwards, and deaths are likely to decline further in Europe in the current decade.
56 citations
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TL;DR: Using national mortality data to compare specific death rates from testicular cancer in western and eastern Europe, the USA, and Japan, it is found that many avoidable deaths, mainly in young adults, are still occurring in eastern Europe.
56 citations
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Utrecht University1, University of Malaya2, Ministry of Health (Malaysia)3, Imperial College London4, Aarhus University5, University of Paris-Sud6, Institut Gustave Roussy7, German Cancer Research Center8, National and Kapodistrian University of Athens9, University of Naples Federico II10, Prevention Institute11, Wageningen University and Research Centre12, University of Tromsø13, University of Granada14, Lund University15, Umeå University16, University of Cambridge17, Medical Research Council18, Cancer Epidemiology Unit19, International Agency for Research on Cancer20, Queen Mary University of London21
TL;DR: Higher caffeinated coffee consumption may be associated with lower risk of postmenopausal breast cancer, and decaffeinated coffee intake does not seem to be associatedWith breast cancer.
Abstract: Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P-trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P-trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.
55 citations
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University of Paris1, International Agency for Research on Cancer2, Imperial College London3, Aarhus University4, University of Copenhagen5, Université Paris-Saclay6, Institut Gustave Roussy7, German Cancer Research Center8, University of Potsdam9, National and Kapodistrian University of Athens10, Prevention Institute11, University Medical Center Utrecht12, University of Tromsø13, University of Granada14, Andalusian School of Public Health15, University of Antioquia16, Basque Government17, Lund University18, Umeå University19, University of Cambridge20, University of Ioannina21, Cancer Epidemiology Unit22
TL;DR: In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with aHigher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm -NPS to characterise healthier food choices in the context of public health policies for European populations.
Abstract: Objective To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide consumers towards healthier food choices, is associated with mortality. Design Population based cohort study. Setting European Prospective Investigation into Cancer and Nutrition (EPIC) cohort from 23 centres in 10 European countries. Participants 521 324 adults; at recruitment, country specific and validated dietary questionnaires were used to assess their usual dietary intakes. A FSAm-NPS score was calculated for each food item per 100 g content of energy, sugars, saturated fatty acids, sodium, fibre, and protein, and of fruit, vegetables, legumes, and nuts. The FSAm-NPS dietary index was calculated for each participant as an energy weighted mean of the FSAm-NPS score of all foods consumed. The higher the score the lower the overall nutritional quality of the diet. Main outcome measure Associations between the FSAm-NPS dietary index score and mortality, assessed using multivariable adjusted Cox proportional hazards regression models. Results After exclusions, 501 594 adults (median follow-up 17.2 years, 8 162 730 person years) were included in the analyses. Those with a higher FSAm-NPS dietary index score (highest versus lowest fifth) showed an increased risk of all cause mortality (n=53 112 events from non-external causes; hazard ratio 1.07, 95% confidence interval 1.03 to 1.10, P Conclusions In this large multinational European cohort, consuming foods with a higher FSAm-NPS score (lower nutritional quality) was associated with a higher mortality for all causes and for cancer and diseases of the circulatory, respiratory, and digestive systems, supporting the relevance of FSAm-NPS to characterise healthier food choices in the context of public health policies (eg, the Nutri-Score) for European populations. This is important considering ongoing discussions about the potential implementation of a unique nutrition labelling system at the European Union level.
55 citations
Authors
Showing all 669 results
Name | H-index | Papers | Citations |
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Richard Peto | 183 | 683 | 231434 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Silvia Franceschi | 155 | 1340 | 112504 |
Timothy J. Key | 146 | 808 | 90810 |
Hans-Olov Adami | 145 | 908 | 83473 |
Alicja Wolk | 135 | 778 | 66239 |
Paolo Vineis | 134 | 1088 | 86608 |
Lars Klareskog | 131 | 697 | 63281 |
Eva Negri | 129 | 1010 | 66735 |
John A. Baron | 128 | 609 | 61182 |
Jack Cuzick | 128 | 754 | 79979 |
Anders Ekbom | 116 | 613 | 51430 |
C. La Vecchia | 115 | 817 | 53460 |
Valerie Beral | 114 | 471 | 53729 |
Carlo La Vecchia | 112 | 1265 | 56282 |