Institution
Cancer Epidemiology Unit
About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.
Topics: Population, Cancer, Breast cancer, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study
Papers published on a yearly basis
Papers
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TL;DR: This nomogram based on preoperative risk factors may assist surgeons in decision making to minimize risk by either not restoring bowel continuity or protecting the anastomosis with a temporary diverting stoma.
Abstract: Anastomotic leak after rectal cancer surgery is a severe complication associated with poorer oncologic outcome and quality of life. Preoperative assessment of the risk for anastomotic leak is a key component of surgical planning, including the opportunity to create a defunctioning stoma. The purpose of this study was to identify and quantify the risk factors for anastomotic leak to minimize risk by either not restoring bowel continuity or protecting the anastomosis with a temporary diverting stoma. Potentially relevant studies were identified from the following databases: PubMed, Embase and Cochrane Library. This meta-analysis included studies on transabdominal resection for rectal cancer that reported data about anastomotic leak. The risk for anastomotic leak after rectal cancer surgery was investigated. Preoperative, intraoperative, and postoperative factors were extracted and used to compare anastomotic leak rates. All variables demonstrating a p value 0.0791 to identify anastomotic leak were 79.1% and 32.9%, respectively. Accuracy of the threshold value was confirmed in the validation set with 77.8% sensitivity and 35.2% specificity. We trust that, with further refinement using prospective data, this nomogram based on preoperative risk factors may assist surgeons in decision making. The score is now available online (
http://www.real-score.org
).
37 citations
TL;DR: Trends in cancer incidence in the whole of Sweden for the period 1958 to 1987 predict a continuing rise in the incidence rate of cancer, and suggest a worrying pattern of increasing population exposure to carcinogenic influences.
36 citations
TL;DR: Gene methylation in NTAT is a possible prognostic marker to be evaluated in clinical studies and may play a role in cancer progression.
Abstract: Background
Markers that can discriminate between indolent and aggressive prostate tumours are needed. We studied gene methylation in non-neoplastic tissue adjacent to prostate tumour (NTAT) in association with prostate cancer mortality.
36 citations
TL;DR: The EUROCARE database represents a unique source of information on survival of childhood cancer patients in Europe, intercountry differences and time trends in survival, and the methodology used to analyse and report survival.
36 citations
University of California, San Diego1, Institute of Cancer Research2, University of Manchester3, University of Warwick4, Turku University Hospital5, University of Turku6, University College London7, University of Cambridge8, Translational Research Institute9, Queensland University of Technology10, Karolinska Institutet11, John Radcliffe Hospital12, University of Bristol13, University of Oxford14, National Institute for Health Research15, Medical Research Council16, Copenhagen University Hospital17, University of Copenhagen18, Fred Hutchinson Cancer Research Center19, University of Melbourne20, Monash University, Clayton campus21, Cancer Council Victoria22, Uppsala University23, Cancer Epidemiology Unit24, Vanderbilt University Medical Center25, Meharry Medical College26, University of Washington27, Harvard University28, Manchester Academic Health Science Centre29, Brigham and Women's Hospital30, University of Paris31, Aarhus University Hospital32, Aarhus University33, Pomeranian Medical University34, Oslo University Hospital35, University of Paris-Sud36, Université Paris-Saclay37, University of Southern California38, University of Toronto39, Princess Margaret Cancer Centre40, Mayo Clinic41, Icahn School of Medicine at Mount Sinai42, Queen Mary University of London43, Pompeu Fabra University44, University of Texas MD Anderson Cancer Center45, University of Porto46, University of Rennes47, University of Texas Health Science Center at San Antonio48, United States Department of Veterans Affairs49, University of Utah50, German Cancer Research Center51, Stanford University52, Sofia Medical University53, City of Hope National Medical Center54, Ghent University55, University of Surrey56, University of Malaya57, University of Tennessee Health Science Center58, University Hospital Centre Zagreb59, Cross Cancer Institute60, University of Alberta61, Katholieke Universiteit Leuven62, Case Western Reserve University63, Erasmus University Medical Center64, Université de Montréal65, Institut national de la recherche scientifique66, University of Miami67
TL;DR: In this paper, a polygenic hazard score (PHS2) is associated with age at diagnosis of any and aggressive prostate cancer, stage T3-T4, PSA ≥ 10 ng/mL or nodal/distant metastasis.
Abstract: Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
36 citations
Authors
Showing all 669 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Richard Peto | 183 | 683 | 231434 |
| Kay-Tee Khaw | 174 | 1389 | 138782 |
| Silvia Franceschi | 155 | 1340 | 112504 |
| Timothy J. Key | 146 | 808 | 90810 |
| Hans-Olov Adami | 145 | 908 | 83473 |
| Alicja Wolk | 135 | 778 | 66239 |
| Paolo Vineis | 134 | 1088 | 86608 |
| Lars Klareskog | 131 | 697 | 63281 |
| Eva Negri | 129 | 1010 | 66735 |
| John A. Baron | 128 | 609 | 61182 |
| Jack Cuzick | 128 | 754 | 79979 |
| Anders Ekbom | 116 | 613 | 51430 |
| C. La Vecchia | 115 | 817 | 53460 |
| Valerie Beral | 114 | 471 | 53729 |
| Carlo La Vecchia | 112 | 1265 | 56282 |