Institution
Cancer Epidemiology Unit
About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.
Topics: Population, Cancer, Breast cancer, European Prospective Investigation into Cancer and Nutrition, Prospective cohort study
Papers published on a yearly basis
Papers
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TL;DR: In reviewing the current evidence related to excess body fat and cancer, the European Code against Cancer Nutrition Working Group has developed the following recommendation: 'Take action to be a healthy body weight'.
109 citations
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TL;DR: This study provides strong evidence that asbestos pollution from an industrial source greatly increases mesothelioma risk and relative risks from occupational exposure were underestimated and were markedly increased when adjusted for residential distance.
Abstract: BackgroundEnvironmental asbestos pollution can cause malignant mesothelioma, but few studies have involved dose–response analyses with detailed information on occupational, domestic, and environmen...
109 citations
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TL;DR: IARC Monographs provide strengthened evidence that the consumption of alcoholic beverages is causally associated with cancers of the oral cavity, pharynX, larynx, oesophagus, liver, colorectum and female breast, even for low and moderate alcohol intakes.
109 citations
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TL;DR: The polygenic risk score was substantially more predictive of ER-positive than of ER -negative breast cancer, particularly for absolute risk.
Abstract: Context There is limited evidence on how the risk of breast cancer and its subtypes depend on low-penetrance susceptibility loci, individually or in combination. Objective To analyze breast cancer risk, overall and by tumor subtype, in relation to 14 individual single-nucleotide polymorphisms (SNPs) previously linked to the disease, and in relation to a polygenic risk score. Design, Setting, and Participants Study of 10 306 women with breast cancer (mean age at diagnosis, 58 years) and 10 393 women without breast cancer who in 2005-2008 provided blood samples for genotyping in a large prospective study of UK women; and meta-analysis of these results and of other published results. Main Outcome Measures Estimated per-allele odds ratio (OR) for individual SNPs, and cumulative incidence of breast cancer to age 70 years in relation to a polygenic risk score based on the 4, 7, or 10 SNPs most strongly associated with risk. Results Odds ratios for breast cancer were greatest for FGFR2-rs2981582 and TNRC9-rs3803662 and, for these 2 SNPs, were significantly greater for estrogen receptor (ER)–positive than for ER-negative disease, both in our data and in meta-analyses of all published data (pooled per-allele ORs [95% confidence intervals] for ER-positive vs ER-negative disease: 1.30 [1.26-1.33] vs 1.05 [1.01-1.10] for FGFR2; interaction P Conclusions The polygenic risk score was substantially more predictive of ER-positive than of ER-negative breast cancer, particularly for absolute risk.
109 citations
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TL;DR: It is demonstrated that high intake of fruits and vegetables may be particularly beneficial in smokers, and the risk estimates associated with cigarette smoking were higher among those with low fruit consumption than among frequent fruit‐eaters.
Abstract: Previous studies have provided conflicting information on the role of tobacco and alcohol in gastric carcinogenesis. A population-based case-control study with 338 histologically confirmed gastric-cancer cases and 679 control subjects was conducted. Information relating to life-time tobacco consumption, alcohol intake and diet during adolescence and 20 years before interview, and to socio-economic conditions was obtained through face-to-face interviews. Current cigarette smokers were found to have a greater risk than non-users of tobacco. The duration of cigarette or pipe smoking was positively associated with gastric-cancer risk. There was significant interaction between tobacco use and fruit consumption. High fruit intake was more protective among users of tobacco than among non-users, and the risk estimates associated with cigarette smoking were higher among those with low fruit consumption than among frequent fruit-eaters. Likewise, though to a lesser extent, vegetable intake interacted with tobacco use. Snuff dipping and alcohol intake was not associated with gastric-cancer risk. However, high alcohol intake tended to increase the risk associated with tobacco use. This study adds further support to the role of tobacco smoking in gastric carcinogenesis, and demonstrates that high intake of fruits and vegetables may be particularly beneficial in smokers. © Wiley-Liss, Inc.
109 citations
Authors
Showing all 669 results
Name | H-index | Papers | Citations |
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Richard Peto | 183 | 683 | 231434 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Silvia Franceschi | 155 | 1340 | 112504 |
Timothy J. Key | 146 | 808 | 90810 |
Hans-Olov Adami | 145 | 908 | 83473 |
Alicja Wolk | 135 | 778 | 66239 |
Paolo Vineis | 134 | 1088 | 86608 |
Lars Klareskog | 131 | 697 | 63281 |
Eva Negri | 129 | 1010 | 66735 |
John A. Baron | 128 | 609 | 61182 |
Jack Cuzick | 128 | 754 | 79979 |
Anders Ekbom | 116 | 613 | 51430 |
C. La Vecchia | 115 | 817 | 53460 |
Valerie Beral | 114 | 471 | 53729 |
Carlo La Vecchia | 112 | 1265 | 56282 |