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Institution

Cancer Epidemiology Unit

About: Cancer Epidemiology Unit is a based out in . It is known for research contribution in the topics: Population & Cancer. The organization has 669 authors who have published 1725 publications receiving 93979 citations.


Papers
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Journal ArticleDOI
TL;DR: It is concluded that epidemiologic studies provide little support for existence of a widespread TDS because there are no consistent non-causal associations between its different manifestations and furthermore little evidence of shared causes between the alleged components of the syndrome.
Abstract: The concept of an increasingly common Testicular Dysgenesis Syndrome (TDS) has been widely adopted with little epidemiological appraisal. In this paper we critically review the epidemiologic evidence of the existence of a non-genetic TDS. We systematically assess and discuss the evidence of all six possible associations between the four defining conditions of TDS: impaired spermatogenesis, undescended testis, hypospadia and testicular cancer. We also evaluate whether there are common risk factors for these four conditions. We conclude that epidemiologic studies provide little support for existence of a widespread TDS because there are no consistent non-causal associations between its different manifestations. There is furthermore little evidence of shared causes between the alleged components of the syndrome.

90 citations

Journal ArticleDOI
TL;DR: Cigarette smoking could be a risk factor for follicular NHL among women among women and for HD, MM, or LEU, no clear association was observed.
Abstract: Objective: Tobacco use is the most prominent cause of respiratory cancers. Little is known, however, about the influence of smoking on hematolymphopoietic malignancies. To evaluate this relation, a population-based case–control study was carried out in 12 areas of Italy. Methods: Detailed interviews on tobacco smoking habits were administered to 1450 non-Hodgkin's lymphoma (NHL), 365 Hodgkin's disease (HD), 270 multiple myeloma (MM), and 649 leukemia (LEU) patients occurring from 1990 to 1993, and 1779 population controls. Results: We found a slightly increased risk for NHL in smokers (odds ratio 1.2, 95% confidence interval 1.0–1.4 for ever smokers), but a consistent positive association was shown only for follicular NHL. In this subtype, a significant excess risk was observed for ever versus never smokers, after adjustment for gender, age, geographic residence, education, and respondent (OR = 1.8, 95%, CI 1.3–2.7), with a positive exposure–response gradient for smoking duration (p<0.01). The risk for follicular NHL was significantly elevated only among women, with ever smokers showing OR = 2.3 (CI 1.4–3.8), while for men we found OR = 1.3 (CI 0.69–2.3). No major differences were shown according to age. Female subjects also showed significant positive exposure–response trends for duration. Conclusion: Cigarette smoking could be a risk factor for follicular NHL among women. For HD, MM, or LEU, no clear association was observed.

90 citations

Journal ArticleDOI
TL;DR: The results support a probable causal relationship between circulating IGF-1 concentrations and breast cancer, suggesting that interventions targeting the IGF pathway may be beneficial in preventing breast tumorigenesis.

90 citations

Journal ArticleDOI

90 citations

Journal ArticleDOI
02 Sep 2013-PLOS ONE
TL;DR: The results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk and the inverse associations the authors observed did not differ by the fat content of the dairy products considered.
Abstract: Background: Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. However, less is known about whether the inverse associations vary for individual dairy products with differing fat contents. Materials and Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between intakes of total milk and milk subtypes (whole-fat, semi-skimmed and skimmed), yoghurt, cheese, and dietary calcium with colorectal cancer risk amongst 477,122 men and women. Dietary questionnaires were administered at baseline. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for relevant confounding variables. Results: During the mean 11 years of follow-up, 4,513 incident cases of colorectal cancer occurred. After multivariable adjustments, total milk consumption was inversely associated with colorectal cancer risk (HR per 200 g/day 0.93, 95% CI: 0.89-0.98). Similar inverse associations were observed for whole-fat (HR per 200 g/day 0.90, 95% CI: 0.82-0.99) and skimmed milk (HR per 200 g/day 0.90, 95% CI: 0.79-1.02) in the multivariable models. Inverse associations were observed for cheese and yoghurt in the categorical models; although in the linear models, these associations were non-significant. Dietary calcium was inversely associated with colorectal cancer risk (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99); this association was limited to dairy sources of calcium only (HR per 200 mg/day 0.95, 95% CI: 0.91-0.99), with no association observed for non-dairy calcium sources (HR per 200 mg/day 1.00, 95% CI: 0.81-1.24). Conclusions: Our results strengthen the evidence for a possible protective role of dairy products on colorectal cancer risk. The inverse associations we observed did not differ by the fat content of the dairy products considered.

90 citations


Authors

Showing all 669 results

NameH-indexPapersCitations
Richard Peto183683231434
Kay-Tee Khaw1741389138782
Silvia Franceschi1551340112504
Timothy J. Key14680890810
Hans-Olov Adami14590883473
Alicja Wolk13577866239
Paolo Vineis134108886608
Lars Klareskog13169763281
Eva Negri129101066735
John A. Baron12860961182
Jack Cuzick12875479979
Anders Ekbom11661351430
C. La Vecchia11581753460
Valerie Beral11447153729
Carlo La Vecchia112126556282
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2021174
2020131
2019130
201890
201784
201678