Cardiff Metropolitan University

About: Cardiff Metropolitan University is a education organization based out in Cardiff, United Kingdom. It is known for research contribution in the topics: Tourism & Population. The organization has 1337 authors who have published 2958 publications receiving 72104 citations. The organization is also known as: UWIC & University of Wales Institute, Cardiff.

Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

Abstract: Normal cells can permanently lose the ability to proliferate when challenged by potentially oncogenic stress, a process termed cellular senescence. Senescence-associated beta-galactosidase (SA-betagal) activity, detectable at pH 6.0, permits the identification of senescent cells in culture and mammalian tissues. Here we describe first a cytochemical protocol suitable for the histochemical detection of individual senescent cells both in culture and tissue biopsies. The second method is based on the alkalinization of lysosomes, followed by the use of 5-dodecanoylaminofluorescein di-beta-D-galactopyranoside (C12FDG), a fluorogenic substrate for betagal activity. The cytochemical method takes about 30 min to execute, and several hours to a day to develop and score. The fluorescence methods take between 4 and 8 h to execute and can be scored in a single day. The cytochemical method is applicable to tissue sections and requires simple reagents and equipment. The fluorescence-based methods have the advantages of being more quantitative and sensitive.

The use of performance indicators in performance analysis

Abstract: The aims of this paper are to examine the application of performance indicators in different sports and, using the different structural definitions of games, to make general recommendations about the use and application of these indicators. Formal games are classified into three categories: net and wall games, invasion games, and striking and fielding games. The different types of sports are also sub-categorized by the rules of scoring and ending the respective matches. These classes are analysed further, to enable definition of useful performance indicators and to examine similarities and differences in the analysis of the different categories of game. The indices of performance are sub-categorized into general match indicators, tactical indicators, technical indicators and biomechanical indicators. Different research examples and the accuracy of their presentation are discussed. We conclude that, to enable a full and objective interpretation of the data from the analysis of a performance, comparisons of data are vital. In addition, any analysis of the distribution of actions across the playing surface should also be presented normalized, or non-dimensionalized, to the total distribution of actions across the area. Other normalizations of performance indicators should also be used more widely in conjunction with the accepted forms of data analysis. Finally, we recommend that biomechanists should pay more attention to games to enrich the analysis of performance in these sports.

Movement systems as dynamical systems: The functional role of variability and its implications for sports medicine

Abstract: In recent years, concepts and tools from dynamical systems theory have been successfully applied to the study of movement systems, contradicting traditional views of variability as noise or error. From this perspective, it is apparent that variability in movement systems is omnipresent and unavoidable due to the distinct constraints that shape each individual's behaviour. In this position paper, it is argued that trial-to-trial movement variations within individuals and performance differences observed between individuals may be best interpreted as attempts to exploit the variability that is inherent within and between biological systems. That is, variability in movement systems helps individuals adapt to the unique constraints (personal, task and environmental) impinging on them across different timescales. We examine the implications of these ideas for sports medicine, by: (i) focusing on intra-individual variability in postural control to exemplify within-individual real-time adaptations to changing informational constraints in the performance environment; and (ii) interpreting recent evidence on the role of the angiotensin-converting enzyme gene as a genetic (developmental) constraint on individual differences in physical performance. The implementation of a dynamical systems theoretical interpretation of variability in movement systems signals a need to re-evaluate the ubiquitous influence of the traditional 'medical model' in interpreting motor behaviour and performance constrained by disease or injury to the movement system. Accordingly, there is a need to develop new tools for providing individualised plots of motor behaviour and performance as a function of key constraints. Coordination profiling is proposed as one such alternative approach for interpreting the variability and stability demonstrated by individuals as they attempt to construct functional, goal-directed patterns of motor behaviour during each unique performance. Finally, the relative contribution of genes and training to between-individual performance variation is highlighted, with the conclusion that dynamical systems theory provides an appropriate multidisciplinary theoretical framework to explain their interaction in supporting physical performance.

Destination branding and the role of the stakeholders: the case of New Zealand

Abstract: Managing a destination brand presents many challenges, and this paper opens by briefly reviewing the destination brand management context. It focuses particularly on the political processes involved in successful brand management and on the vital role of public and private sector stakeholders. Critical to the creation of a durable destination brand is the identification of the brand’s values, the translation of those into a suitably emotionally appealing personality and the targeted and efficient delivery of that message. While this is difficult to achieve in destination marketing, it is not impossible and, having reviewed some of the key issues in brand management, the paper explores the context and creation of the New Zealand brand. It identifies the stakeholders crucial to the delivery of this destination brand and examines the positioning process and the creation of its largely web-driven strategy. The paper suggests that through stakeholder partnerships and the harnessing of non-traditional media, To...