Carleton University

About: Carleton University is a education organization based out in Ottawa, Ontario, Canada. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 15852 authors who have published 39650 publications receiving 1106610 citations.

Measurement of the total active B-8 solar neutrino flux at the Sudbury Neutrino Observatory with enhanced neutral current sensitivity

Abstract: The Sudbury Neutrino Observatory has precisely determined the total active (nu(x)) B-8 solar neutrino flux without assumptions about the energy dependence of the nu(e) survival probability. The measurements were made with dissolved NaCl in heavy water to enhance the sensitivity and signature for neutral-current interactions. The flux is found to be 5.21+/-0.27(stat)+/-0.38(syst)x10(6) cm(-2) s(-1), in agreement with previous measurements and standard solar models. A global analysis of these and other solar and reactor neutrino results yields Deltam(2)=7.1(-0.6)(+1.2)x10(-5) eV(2) and theta= 32.5(-2.3)(+2.4) degrees. Maximal mixing is rejected at the equivalent of 5.4 standard deviations.

Earthquake Ground-Motion Prediction Equations for Eastern North America

Abstract: New earthquake ground-motion relations for hard-rock and soil sites in eastern North America (ENA), including estimates of their aleatory uncertainty (vari- ability) have been developed based on a stochastic finite-fault model. The model incorporates new information obtained from ENA seismographic data gathered over the past 10 years, including three-component broadband data that provide new in- formation on ENA source and path effects. Our new prediction equations are similar to the previous ground-motion prediction equations of Atkinson and Boore (1995), which were based on a stochastic point-source model. The main difference is that high-frequency amplitudes (f 5 Hz) are less than previously predicted (by about a factor of 1.6 within 100 km), because of a slightly lower average stress parameter (140 bars versus 180 bars) and a steeper near-source attenuation. At frequencies less than 5 Hz, the predicted ground motions from the new equations are generally within 25% of those predicted by Atkinson and Boore (1995). The prediction equations agree well with available ENA ground-motion data as evidenced by near-zero average residuals (within a factor of 1.2) for all frequencies, and the lack of any significant residual trends with distance. However, there is a tendency to positive residuals for moderate events at high frequencies in the distance range from 30 to 100 km (by as much as a factor of 2). This indicates epistemic uncertainty in the prediction model. The positive residuals for moderate events at 100 km could be eliminated by an increased stress parameter, at the cost of producing negative residuals in other magnitude-distance ranges; adjustment factors to the equations are provided that may be used to model this effect.

Country equity and country branding: Problems and prospects

Abstract: This paper surveys and reviews the voluminous research on product-country images and their effects, with the objectives of discussing the multi-faceted nature of country equity and its importance, and identifying knowledge gaps and misconceptions that often impede the development of successful business or national strategies based on effective country branding. The paper concludes that country-based marketing is often underused or misdirected due to inadequate understanding of the meaning of 'country branding', and suggests approaches for strategy development as well as pointing to knowledge gaps that call for additional research.

NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

Abstract: Despite recent therapeutic advances, multiple myeloma (MM) remains largely incurable. Here we report results of a phase I/II trial to evaluate the safety and activity of autologous T cells engineered to express an affinity-enhanced T cell receptor (TCR) recognizing a naturally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1. Twenty patients with antigen-positive MM received an average 2.4 × 10(9) engineered T cells 2 d after autologous stem cell transplant. Infusions were well tolerated without clinically apparent cytokine-release syndrome, despite high IL-6 levels. Engineered T cells expanded, persisted, trafficked to marrow and exhibited a cytotoxic phenotype. Persistence of engineered T cells in blood was inversely associated with NY-ESO-1 levels in the marrow. Disease progression was associated with loss of T cell persistence or antigen escape, in accordance with the expected mechanism of action of the transferred T cells. Encouraging clinical responses were observed in 16 of 20 patients (80%) with advanced disease, with a median progression-free survival of 19.1 months. NY-ESO-1-LAGE-1 TCR-engineered T cells were safe, trafficked to marrow and showed extended persistence that correlated with clinical activity against antigen-positive myeloma.