Carnegie Mellon University

About: Carnegie Mellon University is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Computer science & Robot. The organization has 36317 authors who have published 104359 publications receiving 5975734 citations. The organization is also known as: CMU & Carnegie Mellon.

STEM: a tool for the analysis of short time series gene expression data

Abstract: Time series microarray experiments are widely used to study dynamical biological processes. Due to the cost of microarray experiments, and also in some cases the limited availability of biological material, about 80% of microarray time series experiments are short (3–8 time points). Previously short time series gene expression data has been mainly analyzed using more general gene expression analysis tools not designed for the unique challenges and opportunities inherent in short time series gene expression data. We introduce the Short Time-series Expression Miner (STEM) the first software program specifically designed for the analysis of short time series microarray gene expression data. STEM implements unique methods to cluster, compare, and visualize such data. STEM also supports efficient and statistically rigorous biological interpretations of short time series data through its integration with the Gene Ontology. The unique algorithms STEM implements to cluster and compare short time series gene expression data combined with its visualization capabilities and integration with the Gene Ontology should make STEM useful in the analysis of data from a significant portion of all microarray studies. STEM is available for download for free to academic and non-profit users at http://www.cs.cmu.edu/~jernst/stem .

Autonomous driving in urban environments: Boss and the Urban Challenge

Abstract: Boss is an autonomous vehicle that uses on-board sensors (global positioning system, lasers, radars, and cameras) to track other vehicles, detect static obstacles, and localize itself relative to a road model. A three-layer planning system combines mission, behavioral, and motion planning to drive in urban environments. The mission planning layer considers which street to take to achieve a mission goal. The behavioral layer determines when to change lanes and precedence at intersections and performs error recovery maneuvers. The motion planning layer selects actions to avoid obstacles while making progress toward local goals. The system was developed from the ground up to address the requirements of the DARPA Urban Challenge using a spiral system development process with a heavy emphasis on regular, regressive system testing. During the National Qualification Event and the 85-km Urban Challenge Final Event, Boss demonstrated some of its capabilities, qualifying first and winning the challenge. © 2008 Wiley Periodicals, Inc.

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies and the Distant Universe

Abstract: We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median $z\sim 0.03$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $z\sim 0.6$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July.

Efficient clustering of high-dimensional data sets with application to reference matching

Abstract: important problems involve clustering large datasets. Although naive implementations of clustering are computa- tionally expensive, there are established ecient techniques for clustering when the dataset has either (1) a limited num- ber of clusters, (2) a low feature dimensionality, or (3) a small number of data points. However, there has been much less work on methods of eciently clustering datasets that are large in all three ways at once|for example, having millions of data points that exist in many thousands of di- mensions representing many thousands of clusters. We present a new technique for clustering these large, high- dimensional datasets. The key idea involves using a cheap, approximate distance measure to eciently divide the data into overlapping subsets we call canopies .T hen cluster- ing is performed by measuring exact distances only between points that occur in a common canopy. Using canopies, large clustering problems that were formerly impossible become practical. Under reasonable assumptions about the cheap distance metric, this reduction in computational cost comes without any loss in clustering accuracy. Canopies can be applied to many domains and used with a variety of cluster- ing approaches, including Greedy Agglomerative Clustering, K-means and Expectation-Maximization. We present ex- perimental results on grouping bibliographic citations from the reference sections of research papers. Here the canopy approach reduces computation time over a traditional clus- tering approach by more than an order of magnitude and decreases error in comparison to a previously used algorithm by 25%.