Carnegie Mellon University

About: Carnegie Mellon University is a education organization based out in Pittsburgh, Pennsylvania, United States. It is known for research contribution in the topics: Computer science & Robot. The organization has 36317 authors who have published 104359 publications receiving 5975734 citations. The organization is also known as: CMU & Carnegie Mellon.

Supervised Descent Method and Its Applications to Face Alignment

Abstract: Many computer vision problems (e.g., camera calibration, image alignment, structure from motion) are solved through a nonlinear optimization method. It is generally accepted that 2nd order descent methods are the most robust, fast and reliable approaches for nonlinear optimization of a general smooth function. However, in the context of computer vision, 2nd order descent methods have two main drawbacks: (1) The function might not be analytically differentiable and numerical approximations are impractical. (2) The Hessian might be large and not positive definite. To address these issues, this paper proposes a Supervised Descent Method (SDM) for minimizing a Non-linear Least Squares (NLS) function. During training, the SDM learns a sequence of descent directions that minimizes the mean of NLS functions sampled at different points. In testing, SDM minimizes the NLS objective using the learned descent directions without computing the Jacobian nor the Hessian. We illustrate the benefits of our approach in synthetic and real examples, and show how SDM achieves state-of-the-art performance in the problem of facial feature detection. The code is available at www.humansensing.cs. cmu.edu/intraface.

An Evaluation of Statistical Approaches to Text Categorization

Abstract: This paper focuses on a comparative evaluation of a wide-range of text categorization methods, including previously published results on the Reuters corpus and new results of additional experiments. A controlled study using three classifiers, kNN, LLSF and WORD, was conducted to examine the impact of configuration variations in five versions of Reuters on the observed performance of classifiers. Analysis and empirical evidence suggest that the evaluation results on some versions of Reuters were significantly affected by the inclusion of a large portion of unlabelled documents, mading those results difficult to interpret and leading to considerable confusions in the literature. Using the results evaluated on the other versions of Reuters which exclude the unlabelled documents, the performance of twelve methods are compared directly or indirectly. For indirect compararions, kNN, LLSF and WORD were used as baselines, since they were evaluated on all versions of Reuters that exclude the unlabelled documents. As a global observation, kNN, LLSF and a neural network method had the best performances except for a Naive Bayes approach, the other learning algorithms also performed relatively well.

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

Abstract: Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vivo delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy.

Clinical versus actuarial judgment

Abstract: Professionals are frequently consulted to diagnose and predict human behavior; optimal treatment and planning often hinge on the consultant's judgmental accuracy. The consultant may rely on one of two contrasting approaches to decision-making--the clinical and actuarial methods. Research comparing these two approaches shows the actuarial method to be superior. Factors underlying the greater accuracy of actuarial methods, sources of resistance to the scientific findings, and the benefits of increased reliance on actuarial approaches are discussed.

Compilation and analysis of Escherichia coli promoter DNA sequences.

Abstract: The DNA sequence of 168 promoter regions (-50 to +10) for Escherichia coli RNA polymerase were compiled. The complete listing was divided into two groups depending upon whether or not the promoter had been defined by genetic (promoter mutations) or biochemical (5' end determination) criteria. A consensus promoter sequence based on homologies among 112 well-defined promoters was determined that was in substantial agreement with previous compilations. In addition, we have tabulated 98 promoter mutations. Nearly all of the altered base pairs in the mutants conform to the following general rule: down-mutations decrease homology and up-mutations increase homology to the consensus sequence.