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Institution

Carolinas Medical Center

HealthcareCharlotte, North Carolina, United States
About: Carolinas Medical Center is a healthcare organization based out in Charlotte, North Carolina, United States. It is known for research contribution in the topics: Population & Emergency department. The organization has 2781 authors who have published 4710 publications receiving 181835 citations.


Papers
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Journal ArticleDOI
TL;DR: Among patients with heart failure and moderate‐to‐severe or severe secondary mitral regurgitation who remained symptomatic despite the use of maximal doses of guideline‐directed medical therapy, transcatheter mitral‐valve repair resulted in a lower rate of hospitalization forHeart failure and lower all‐cause mortality within 24 months of follow‐up than medical therapy alone.
Abstract: Background Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor Transcatheter mitral-valve repair may improve their clinical outcomes Methods At 78 sites in the United States and Canada, we enrolled patients with heart failure and moderate-to-severe or severe secondary mitral regurgitation who remained symptomatic despite the use of maximal doses of guideline-directed medical therapy Patients were randomly assigned to transcatheter mitral-valve repair plus medical therapy (device group) or medical therapy alone (control group) The primary effectiveness end point was all hospitalizations for heart failure within 24 months of follow-up The primary safety end point was freedom from device-related complications at 12 months; the rate for this end point was compared with a prespecified objective performance goal of 880% Results Of the 614 patients who were enrolled in the trial, 302 were assigned to the device group and 312 t

1,758 citations

Journal ArticleDOI
TL;DR: The clinical need for bone tissue-engineered alternatives to the present materials used in bone grafting techniques is presented, a status report on clinically availableBone tissue-engineering devices, and recent advances in biomaterials research are presented.

1,576 citations

Journal ArticleDOI
TL;DR: Although percutaneous repair was less effective at reducing mitral regurgitation than conventional surgery, the procedure was associated with superior safety and similar improvements in clinical outcomes.
Abstract: Background Mitral-valve repair can be accomplished with an investigational procedure that involves the percutaneous implantation of a clip that grasps and approximates the edges of the mitral leaflets at the origin of the regurgitant jet. Methods We randomly assigned 279 patients with moderately severe or severe (grade 3+ or 4+) mitral regurgitation in a 2:1 ratio to undergo either percutaneous repair or conventional surgery for repair or replacement of the mitral valve. The primary composite end point for efficacy was freedom from death, from surgery for mitral-valve dysfunction, and from grade 3+ or 4+ mitral regurgitation at 12 months. The primary safety end point was a composite of major adverse events within 30 days. Results At 12 months, the rates of the primary end point for efficacy were 55% in the percutaneous-repair group and 73% in the surgery group (P=0.007). The respective rates of the components of the primary end point were as follows: death, 6% in each group; surgery for mitral-valve dysfu...

1,468 citations

Journal ArticleDOI
TL;DR: Laparoscopic liver surgery is a safe and effective approach to the management of surgical liver disease in the hands of trained surgeons with experience in hepatobiliary and laparoscopic surgery, and national and international societies should become involved in the goal of establishing training standards and credentialing.
Abstract: Objective:To summarize the current world position on laparoscopic liver surgery.Summary Background Data:Multiple series have reported on the safety and efficacy of laparoscopic liver surgery. Small and medium sized procedures have become commonplace in many centers, while major laparoscopic liver re

1,366 citations

Journal ArticleDOI
09 Oct 2013-JAMA
TL;DR: The application of SLN surgery for staging the axilla following chemotherapy for women who initially had node-positive cN1 breast cancer is unclear because of high false-negative results reported in previous studies as mentioned in this paper.
Abstract: IMPORTANCE Sentinel lymph node (SLN) surgery provides reliable nodal staging information with less morbidity than axillary lymph node dissection (ALND) for patients with clinically node-negative (cN0) breast cancer. The application of SLN surgery for staging the axilla following chemotherapy for women who initially had node-positive cN1 breast cancer is unclear because of high false-negative results reported in previous studies.

1,105 citations


Authors

Showing all 2797 results

NameH-indexPapersCitations
Jasvinder A. Singh1762382223370
Gerald McGwin9379936798
Michelle A. Williams8663925966
Bruce J. Paster8426128661
Marc F. Swiontkowski8435221392
Ellen S. Vitetta8447325838
Richard J. Barohn7832723499
Paul A. Grayburn7739726880
Jay S. Kaufman7542919014
Jeffrey A. Kline6834217004
Peter A. Banks6734221143
Ronald D. Alvarez6732413962
Herbert L. Bonkovsky6521116685
William K. Smith6520412280
Bradley P. Knight6335415155
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
202219
2021262
2020241
2019211
2018197