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Institution

Case Western Reserve University

EducationCleveland, Ohio, United States
About: Case Western Reserve University is a education organization based out in Cleveland, Ohio, United States. It is known for research contribution in the topics: Population & Health care. The organization has 54617 authors who have published 106568 publications receiving 5071613 citations. The organization is also known as: Case & Case Western.


Papers
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Journal ArticleDOI
03 Feb 2006-Science
TL;DR: It is shown that neuroblast migration parallels cerebrospinal fluid (CSF) flow, and results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.
Abstract: In the adult brain, neuroblasts born in the subventricular zone migrate from the walls of the lateral ventricles to the olfactory bulb. How do these cells orient over such a long distance and through complex territories? Here we show that neuroblast migration parallels cerebrospinal fluid (CSF) flow. Beating of ependymal cilia is required for normal CSF flow, concentration gradient formation of CSF guidance molecules, and directional migration of neuroblasts. Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons.

763 citations

Journal ArticleDOI
TL;DR: In this article, the interaction between serum vitamin D (25-hydroxycholecalciferol) concentrations and VDR genotype on susceptibility to tuberculosis was investigated, and it was found that 25-hydroxcholeciferols deficiency was associated with active tuberculosis (odds ratio 2.9 [95% CI 1.3-6.5], p=0.008).

762 citations

Journal ArticleDOI
TL;DR: In this paper, a new experimental method based on a fusible coating was presented, which showed that the temperature rise, over a few nanoseconds, can be as high as a few thousand kelvin; nevertheless, the temperature rises did not seem to control the shear-band thickness.
Abstract: At ambient temperature the plastic flow shown by metallic glasses is localized into shear bands1,2. This localization and the liquid-like features seen on fracture surfaces are consistent with shear softening in the bands. The extent to which this softening is a result of local heating has remained controversial, with estimates of the local temperature rise ranging from less than 0.1 kelvin to a few thousand kelvin3,4,5,6,7,8,9,10,11. Here we present a new experimental method based on a fusible coating, which shows that the temperature rise, over a few nanoseconds, can be as high as a few thousand kelvin; nevertheless, the temperature rise does not seem to control the shear-band thickness. It is important to understand the mechanisms of shear banding and associated softening because these are the principal factors limiting structural applications of bulk metallic glasses, which have some attractive mechanical properties such as high yield strength12,13.

762 citations

Journal ArticleDOI
TL;DR: The NCCN Guidelines for Pancreatic Adenocarcinoma focus on diagnosis and treatment with systemic therapy, radiation therapy, and surgical resection, as well as on management of locally advanced unresectable and metastatic disease.
Abstract: Ductal adenocarcinoma and its variants account for most pancreatic malignancies. High-quality multiphase imaging can help to preoperatively distinguish between patients eligible for resection with curative intent and those with unresectable disease. Systemic therapy is used in the neoadjuvant or adjuvant pancreatic cancer setting, as well as in the management of locally advanced unresectable and metastatic disease. Clinical trials are critical for making progress in treatment of pancreatic cancer. The NCCN Guidelines for Pancreatic Adenocarcinoma focus on diagnosis and treatment with systemic therapy, radiation therapy, and surgical resection.

762 citations

Journal ArticleDOI
TL;DR: A camera-based method for automatically quantifying the individual and social behaviors of fruit flies, Drosophila melanogaster, interacting in a planar arena finds that behavioral differences between individuals were consistent over time and were sufficient to accurately predict gender and genotype.
Abstract: We present a camera-based method for automatically quantifying the individual and social behaviors of fruit flies, Drosophila melanogaster, interacting in a planar arena Our system includes machine-vision algorithms that accurately track many individuals without swapping identities and classification algorithms that detect behaviors The data may be represented as an ethogram that plots the time course of behaviors exhibited by each fly or as a vector that concisely captures the statistical properties of all behaviors displayed in a given period We found that behavioral differences between individuals were consistent over time and were sufficient to accurately predict gender and genotype In addition, we found that the relative positions of flies during social interactions vary according to gender, genotype and social environment We expect that our software, which permits high-throughput screening, will complement existing molecular methods available in Drosophila, facilitating new investigations into the genetic and cellular basis of behavior

760 citations


Authors

Showing all 54953 results

NameH-indexPapersCitations
Robert Langer2812324326306
Bert Vogelstein247757332094
Zhong Lin Wang2452529259003
John Q. Trojanowski2261467213948
Kenneth W. Kinzler215640243944
Peter Libby211932182724
David Baltimore203876162955
Carlo M. Croce1981135189007
Ronald Klein1941305149140
Eric J. Topol1931373151025
Paul M. Thompson1832271146736
Yusuke Nakamura1792076160313
Dennis J. Selkoe177607145825
David L. Kaplan1771944146082
Evan E. Eichler170567150409
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023142
2022411
20214,337
20204,141
20193,978
20183,663