Institution
Case Western Reserve University
Education•Cleveland, Ohio, United States•
About: Case Western Reserve University is a education organization based out in Cleveland, Ohio, United States. It is known for research contribution in the topics: Population & Health care. The organization has 54617 authors who have published 106568 publications receiving 5071613 citations. The organization is also known as: Case & Case Western.
Topics: Population, Health care, Cancer, Transplantation, Poison control
Papers published on a yearly basis
Papers
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TL;DR: Pulmonary-vein isolation was superior to atrioventricular-node ablation with biventricular pacing in patients with heart failure who had drug-refractory atrial fibrillation.
Abstract: Background Pulmonary-vein isolation is increasingly being used to treat atrial fibrillation in patients with heart failure. Methods In this prospective, multicenter clinical trial, we randomly assigned patients with symptomatic, drug-resistant atrial fibrillation, an ejection fraction of 40% or less, and New York Heart Association class II or III heart failure to undergo either pulmonary-vein isolation or atrioventricular-node ablation with biventricular pacing. All patients completed the Minnesota Living with Heart Failure questionnaire (scores range from 0 to 105, with a higher score indicating a worse quality of life) and underwent echocardiography and a 6-minute walk test (the composite primary end point). Over a 6-month period, patients were monitored for both symptomatic and asymptomatic episodes of atrial fibrillation. Results In all, 41 patients underwent pulmonary-vein isolation, and 40 underwent atrioventricular-node ablation with biventricular pacing; none were lost to follow-up at 6 months. Th...
645 citations
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United States Naval Research Laboratory1, Brookhaven National Laboratory2, Space Sciences Laboratory3, Kingsborough Community College4, University of Münster5, Michigan State University6, Osaka University7, Jet Propulsion Laboratory8, Lawrence Livermore National Laboratory9, Kobe University10, European Synchrotron Radiation Facility11, Washington University in St. Louis12, University of Chicago13, École normale supérieure de Lyon14, University of New Mexico15, Kyushu University16, University of Tokyo17, University of Washington18, Lawrence Berkeley National Laboratory19, University of Jena20, University of Hawaii21, American Museum of Natural History22, Case Western Reserve University23, University of Hyogo24, United States Geological Survey25, Imperial College London26, State University of New York System27, Open University28, Stanford University29
TL;DR: The bulk of the comet 81P/Wild 2 samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger ferromagnesian silicates, Fe-Ni sulfides,Fe-Ni metal, and accessory phases.
Abstract: The bulk of the comet 81P/Wild 2 (hereafter Wild 2) samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger (over 1 micrometer) ferromagnesian silicates, Fe-Ni sulfides, Fe-Ni metal, and accessory phases. The very wide range of olivine and low-Ca pyroxene compositions in comet Wild 2 requires a wide range of formation conditions, probably reflecting very different formation locations in the protoplanetary disk. The restricted compositional ranges of Fe-Ni sulfides, the wide range for silicates, and the absence of hydrous phases indicate that comet Wild 2 experienced little or no aqueous alteration. Less abundant Wild 2 materials include a refractory particle, whose presence appears to require radial transport in the early protoplanetary disk.
644 citations
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TL;DR: In this article, a color Doppler optical coherence tomography (CDOCT) was proposed for in vivo image of blood flow in a hamster subdermal tissue.
Abstract: We describe a novel optical system for bidirectional color Doppler imaging of flow in biological tissues with micrometer-scale resolution and demonstrate its use for in vivo imaging of blood flow in an animal model. Our technique, color Doppler optical coherence tomography (CDOCT), performs spatially localized optical Doppler velocimetry by use of scanning low-coherence interferometry. CDOCT is an extension of optical coherence tomography (OCT), employing coherent signal-acquisition electronics and joint time-frequency analysis algorithms to perform flow imaging simultaneous with conventional OCT imaging. Cross-sectional maps of blood flow velocity with <50-µm spatial resolution and <0.6-mm/s velocity precision were obtained through intact skin in living hamster subdermal tissue. This technology has several potential medical applications.
643 citations
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TL;DR: It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard.
Abstract: Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.
642 citations
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TL;DR: In this article, the authors proposed a mechanism of conductivity for the proton migration in polybenzimidazole (PB1) film, a candidate polymer electrolyte membrane (PEM) for high-temperature (120-200°C) fuel cells, was cast from PBI/trifluoacetyl/H 3 PO 4 solution with constant molecular weight PBI powder and various acid doping levels.
Abstract: Polybenzimidazole (PB1) film, a candidate polymer electrolyte membrane (PEM) for high-temperature (120-200°C) fuel cells, was cast from PBI/trifluoacetyl/H 3 PO 4 solution with constant molecular weight PBI powder and various acid doping levels. Conductivity measurements on these membranes were performed using an ac method under controlled temperature and relative humidity (RH). A complete set of conductivity data for H 3 PO 4 acid-doped PBI is presented as a function of temperature (60-200°C), RH (5-30%), and acid doping level (300-600 mol %). A mechanism of conductivity is proposed for the proton migration in this PBI/acid system based on this and previous work. Proton transfer in this system appears to occur along different paths for different doping levels, RHs, and temperatures. Hydrogen bonds immobilize the anions and form a network for proton transfer by a Grotthuss mechanism. The rate of proton transfer involving H 2 O is faster, leading to higher conductivity at higher RH. The order of the rate of proton transfer between various species is H 3 PO 4 (H 2 PO 4 -)...H-O-H> H 3 PO 4 ...H 2 PO - 4 > N-H + ...H 2 PO 4 - + N-H + ...H-O-H > N-H + ...N-H. The upper limit of proton conductivity is given by the conductivity of the liquid state H 3 PO 4 .
642 citations
Authors
Showing all 54953 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Bert Vogelstein | 247 | 757 | 332094 |
Zhong Lin Wang | 245 | 2529 | 259003 |
John Q. Trojanowski | 226 | 1467 | 213948 |
Kenneth W. Kinzler | 215 | 640 | 243944 |
Peter Libby | 211 | 932 | 182724 |
David Baltimore | 203 | 876 | 162955 |
Carlo M. Croce | 198 | 1135 | 189007 |
Ronald Klein | 194 | 1305 | 149140 |
Eric J. Topol | 193 | 1373 | 151025 |
Paul M. Thompson | 183 | 2271 | 146736 |
Yusuke Nakamura | 179 | 2076 | 160313 |
Dennis J. Selkoe | 177 | 607 | 145825 |
David L. Kaplan | 177 | 1944 | 146082 |
Evan E. Eichler | 170 | 567 | 150409 |