Case Western Reserve University

About: Case Western Reserve University is a education organization based out in Cleveland, Ohio, United States. It is known for research contribution in the topics: Population & Health care. The organization has 54617 authors who have published 106568 publications receiving 5071613 citations. The organization is also known as: Case & Case Western.

Carbon-Based Metal-Free ORR Electrocatalysts for Fuel Cells: Past, Present, and Future.

Abstract: Replacing precious platinum with earth-abundant materials for the oxygen reduction reaction (ORR) in fuel cells has been the objective worldwide for several decades. In the last 10 years, the fastest-growing branch in this area has been carbon-based metal-free ORR electrocatalysts. Great progress has been made in promoting the performance and understanding the underlying fundamentals. Here, a comprehensive review of this field is presented by emphasizing the emerging issues including the predictive design and controllable construction of porous structures and doping configurations, mechanistic understanding from the model catalysts, integrated experimental and theoretical studies, and performance evaluation in full cells. Centering on these topics, the most up-to-date results are presented, along with remarks and perspectives for the future development of carbon-based metal-free ORR electrocatalysts.

Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients.

Abstract: Background Colonization and infection with vancomycin-resistant enterococci have been associated with exposure to antibiotics that are active against anaerobes. In mice that have intestinal colonization with vancomycin-resistant enterococci, these agents promote high-density colonization, whereas antibiotics with minimal antianaerobic activity do not. Methods We conducted a seven-month prospective study of 51 patients who were colonized with vancomycin-resistant enterococci, as evidenced by the presence of the bacteria in stool. We examined the density of vancomycin-resistant enterococci in stool during and after therapy with antibiotic regimens and compared the effect on this density of antianaerobic agents and agents with minimal antianaerobic activity. In a subgroup of 10 patients, cultures of environmental specimens (e.g., from bedding and clothing) were obtained. Results During treatment with 40 of 42 antianaerobic-antibiotic regimens (95 percent), high-density colonization with vancomycin-resistant ...

Anxiety and Social Exclusion

Abstract: This article elaborates a view of anxiety as deriving from a basic human need to belong to social groups. Anxiety is seen as a pervasive and possibly an innately prepared form of distress that arises in response to actual or threatened exclusion from important social groups. The reasons groups exclude individuals (incompetence, deviance or immorality, and unattractiveness) therefore should all be linked to anxiety, and events that implicate the self as incompetent, guilty, or unattractive should create anxiety. This “exclusion theory” of anxiety can be considered a broader revision of separation anxiety theory and is distinguished from theories that base anxiety on fear of death, fear of castration, and perception of uncertainty. Current evidence from multiple sources is reviewed to show the explanatory power and utility of exclusion theory, and implications of this theory are developed in relation to culturally changing standards of sexual behavior, the motivations underlying the Oedipus complex, and the...

Postoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy

Abstract: Purpose A postoperative nomogram for prostate cancer recurrence after radical prostatectomy (RP) has been independently validated as accurate and discriminating. We have updated the nomogram by extending the predictions to 10 years after RP and have enabled the nomogram predictions to be adjusted for the disease-free interval that a patient has maintained after RP. Methods Cox regression analysis was used to model the clinical information for 1,881 patients who underwent RP for clinically-localized prostate cancer by two high-volume surgeons. The model was externally validated separately on two independent cohorts of 1,782 patients and 1,357 patients, respectively. Disease progression was defined as a rising prostate-specific antigen (PSA) level, clinical progression, radiotherapy more than 12 months postoperatively, or initiation of systemic therapy. Results The 10-year progression-free probability for the modeling set was 79% (95% CI, 75% to 82%). Significant variables in the multivariable model include...