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Institution

Case Western Reserve University

EducationCleveland, Ohio, United States
About: Case Western Reserve University is a education organization based out in Cleveland, Ohio, United States. It is known for research contribution in the topics: Population & Health care. The organization has 54617 authors who have published 106568 publications receiving 5071613 citations. The organization is also known as: Case & Case Western.


Papers
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Journal ArticleDOI
TL;DR: The complete human genome nucleotide sequence and technologies for assessing sequence variation on a genome–scale will prompt comprehensive studies of comparative genomic diversity in human populations across the globe.
Abstract: The complete human genome nucleotide sequence and technologies for assessing sequence variation on a genome-scale will prompt comprehensive studies of comparative genomic diversity in human populations across the globe. These studies, besides rejuvenating population genetics and our interest in how genetic variation is created and maintained, will provide the intellectual basis for understanding the genetic basis for complex diseases and traits.

624 citations

Journal ArticleDOI
TL;DR: A revised morphological model for the crimp structure of tendon is presented and small bunches of collagen fibrils removed from the tendon are shown to exhibit the simple planar zig-zag morphology described in previous literature.
Abstract: A revised morphological model for the crimp structure of tendon is presented. The 300-500 mu diameter tendons of the mature rat tail are comprised of from one to more than ten substructures, called fascicles, of 80-320 mu diameter. Fascicles each possess a "crimp structure" demonstrable in the polarizing microscope and neighboring fascicles within a tendon usually exhibit crimp registry. The fascicle itself is shown to be a cylindrical array of planar-zig-zag crimped 500-5000 A diameter collagen fibrils. The approximate cylindrical symmetry of the fascicle is domonstrated by SEM not equal to and polarizing optical microscopy. A method of replacing native water with other liquids of refractive index near to that of collagen is utilized to reduce or eliminate light diffusion and therby greatly improve OM observations. Small bunches of collagen fibrils removed from the tendon are shown to exhibit the simple planar zig-zag morphology described in previous literature. The planar crimping of collagen fibrils and their assemblage into cylindrically symmetric fascicles is verified by small angle X-ray diffraction.

623 citations

Journal ArticleDOI
18 May 2007-Cell
TL;DR: It is shown that, in addition to functioning through RAR, RA activates the "orphan" nuclear receptor PPARbeta/delta, which, in turn, induces the expression of prosurvival genes and opposing effects of RA on cell growth emanate from alternate activation of two different nuclear receptors.

622 citations

Journal ArticleDOI
TL;DR: The authors hypothesize that socially excluded individuals enter a defensive state of cognitive deconstruction that avoids meaningful thought, emotion, and self-awareness, and is characterized by lethargy and altered time flow.
Abstract: The authors hypothesize that socially excluded individuals enter a defensive state of cognitive deconstruction that avoids meaningful thought, emotion, and self-awareness, and is characterized by lethargy and altered time flow. Social rejection led to an overestimation of time intervals, a focus on the present rather than the future, and a failure to delay gratification (Experiment 1). Rejected participants were more likely to agree that "Life is meaningless" (Experiment 2). Excluded participants wrote fewer words and displayed slower reaction times (Experiments 3 and 4). They chose fewer emotion words in an implicit emotion task (Experiment 5), replicating the lack of emotion on explicit measures (Experiments 1-3 and 6). Excluded participants also tried to escape from self-awareness by facing away from a mirror (Experiment 6).

621 citations

Journal ArticleDOI
TL;DR: Results suggest that oxidative damage to cytoplasmic nucleic acid is selectively increased in midbrain, especially the SN, of PD patients and much less so in MSA-P and DLB patients.
Abstract: Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with Parkinson's disease (PD). To investigate the extent and distribution of nucleic acid oxidative damage in these vulnerable dopaminergic neurons, we immunohistochemically characterized a common product of nucleic acid oxidation, 8-hydroxyguanosine (8OHG). In PD patients, cytoplasmic 8OHG immunoreactivity was intense in neurons of the SN, and present to a lesser extent in neurons of the nucleus raphe dorsalis and oculomotor nucleus, and occasionally in glia. The proportion of 8OHG immunoreactive SN neurons was significantly greater in PD patients compared to age-matched controls. Midbrain sections from patients with multiple system atrophy-Parkinsonian type (MSA-P) and dementia with Lewy bodies (DLB) also were examined. These showed increased cytoplasmic 8OHG immunoreactivity in SN neurons in both MSA-P and DLB compared to controls; however, the proportion of positive neurons was significantly less than in PD patients. The regional distribution of 8OHG immunoreactive neurons within the SN corresponded to the distribution of neurodegeneration for these three diseases. Nuclear 8OHG immunoreactivity was not observed in any individual. The type of cytoplasmic nucleic acid responsible for 8OHG immunoreactivity was analyzed by preincubating midbrain sections from PD patients with RNase, DNase, or both enzymes. 8OHG immunoreactivity was substantially diminished by either RNase or DNase, and completely ablated by both enzymes. These results suggest that oxidative damage to cytoplasmic nucleic acid is selectively increased in midbrain, especially the SN, of PD patients and much less so in MSA-P and DLB patients. Moreover, oxidative damage to nucleic acid is largely restricted to cytoplasm with both RNA and mitochondrial DNA as targets.

621 citations


Authors

Showing all 54953 results

NameH-indexPapersCitations
Robert Langer2812324326306
Bert Vogelstein247757332094
Zhong Lin Wang2452529259003
John Q. Trojanowski2261467213948
Kenneth W. Kinzler215640243944
Peter Libby211932182724
David Baltimore203876162955
Carlo M. Croce1981135189007
Ronald Klein1941305149140
Eric J. Topol1931373151025
Paul M. Thompson1832271146736
Yusuke Nakamura1792076160313
Dennis J. Selkoe177607145825
David L. Kaplan1771944146082
Evan E. Eichler170567150409
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023142
2022411
20214,337
20204,141
20193,978
20183,663