Institution
Catholic University of Daegu
Education•Gyeongsan-si, South Korea•
About: Catholic University of Daegu is a education organization based out in Gyeongsan-si, South Korea. It is known for research contribution in the topics: Population & Apoptosis. The organization has 2745 authors who have published 5670 publications receiving 80311 citations.
Topics: Population, Apoptosis, Cancer, MAPK/ERK pathway, Signal transduction
Papers published on a yearly basis
Papers
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TL;DR: Antibacterial activities of chitosan was inversely affected by pH (pH 4.5-5.9 range tested), with higher activity at lower pH value, and bactericidal effects with gram-positive bacteria than gram-negative bacteria in the presence of 0.1% chitOSan.
1,382 citations
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TL;DR: In this article, the authors present an overview on electrochemical characteristics of graphene by summarizing the recent research trend on graphene for energy conversion and storage applications, such as fuel, and present an analysis of the potential of this material for next generation energy conversion devices.
616 citations
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University of Texas Southwestern Medical Center1, University of Glasgow2, Harvard University3, Novartis4, Université de Montréal5, Medical University of South Carolina6, University of Iceland7, University of Western Ontario8, Charles University in Prague9, Saarland University10, Stellenbosch University11, University of Santiago de Compostela12, National Yang-Ming University13, Comenius University in Bratislava14, University of Latvia15, University of Gothenburg16, Universidad Autónoma de Santo Domingo17, University of Paris18, Nanjing Medical University19, Khon Kaen University20, Catholic University of Daegu21, Dokuz Eylül University22, National University of Cordoba23, Semmelweis University24, Central University of Venezuela25, Wrocław Medical University26, University of Eastern Finland27, University of São Paulo28, Aarhus University29, University of Porto30, University of Leicester31, Cleveland Clinic32, University of California, San Francisco33, Katholieke Universiteit Leuven34, Carol Davila University of Medicine and Pharmacy35
TL;DR: Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotens in-converting enzyme inhibition.
Abstract: Background—Clinical trials in heart failure have focused on the improvement in symptoms or decreases in the risk of death and other cardiovascular events. Little is known about the effect of drugs ...
532 citations
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TL;DR: The crystal structure of H. pylori urease is determined and provides a novel example of a molecular assembly adapted for acid resistance that, together with the low Km value of the enzyme, is likely to enable the organism to inhabit the hostile niche.
Abstract: Helicobacter pylori, an etiologic agent in a variety of gastroduodenal diseases, produces a large amount of urease, which is believed to neutralize gastric acid by producing ammonia for the survival of the bacteria. Up to 30% of the enzyme associates with the surface of intact cells upon lysis of neighboring bacteria. The role of the enzyme at the extracellular location has been a subject of controversy because the purified enzyme is irreversibly inactivated below pH 5. We have determined the crystal structure of H. pylori urease, which has a 1.1 MDa spherical assembly of 12 catalytic units with an outer diameter of approximately 160 A. Under physiologically relevant conditions, the activity of the enzyme remains unaffected down to pH 3. Activity assays under different conditions indicated that the cluster of the 12 active sites on the supramolecular assembly may be critical for the survival of the enzyme at low pH. The structure provides a novel example of a molecular assembly adapted for acid resistance that, together with the low Km value of the enzyme, is likely to enable the organism to inhabit the hostile niche.
438 citations
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University of Ulsan1, Korea University2, Chungnam National University3, Chonnam National University4, Keimyung University5, Soonchunhyang University6, Yonsei University7, Kangwon National University8, Hallym University9, Catholic University of Korea10, Catholic University of Daegu11, Chonbuk National University12, Dongguk University13, Inje University14, Kyungpook National University15
TL;DR: The use of dual antiplatelet therapy for a period longer than 12 months in patients who had received drug-eluting stents was not significantly more effective than aspirin monotherapy in reducing the rate of myocardial infarction or death from cardiac causes.
Abstract: Background The potential benefits and risks of the use of dual antiplatelet therapy beyond a 12-month period in patients receiving drug-eluting stents have not been clearly established. Methods In two trials, we randomly assigned a total of 2701 patients who had received drugeluting stents and had been free of major adverse cardiac or cerebrovascular events and major bleeding for a period of at least 12 months to receive clopidogrel plus aspirin or aspirin alone. The primary end point was a composite of myocardial infarction or death from cardiac causes. Data from the two trials were merged for analysis. Results The median duration of follow-up was 19.2 months. The cumulative risk of the primary outcome at 2 years was 1.8% with dual antiplatelet therapy, as compared with 1.2% with aspirin monotherapy (hazard ratio, 1.65; 95% confidence interval [CI], 0.80 to 3.36; P = 0.17). The individual risks of myocardial infarction, stroke, stent thrombosis, need for repeat revascularization, major bleeding, and death from any cause did not differ significantly between the two groups. However, in the dual-therapy group as compared with the aspirin-alone group, there was a nonsignificant increase in the composite risk of myocardial infarction, stroke, or death from any cause (hazard ratio, 1.73; 95% CI, 0.99 to 3.00; P = 0.051) and in the composite risk of myocardial infarction, stroke, or death from cardiac causes (hazard ratio, 1.84; 95% CI, 0.99 to 3.45; P = 0.06). CONCLUSIONS The use of dual antiplatelet therapy for a period longer than 12 months in patients who had received drug-eluting stents was not significantly more effective than aspirin monotherapy in reducing the rate of myocardial infarction or death from cardiac causes. These findings should be confirmed or refuted through larger, randomized clinical trials with longer-term follow-up. (ClinicalTrials.gov numbers, NCT00484926 and NCT00590174.)
411 citations
Authors
Showing all 2758 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jon Zubieta | 79 | 820 | 29114 |
KiHwan Bae | 50 | 276 | 8235 |
M. A. Rao | 49 | 173 | 7792 |
Young Hag Koh | 47 | 178 | 6924 |
Heung Soo Kim | 46 | 372 | 10036 |
Maria Teresa Voso | 46 | 283 | 6815 |
Byung Sun Min | 43 | 385 | 7465 |
Hyo-Jin Kim | 40 | 394 | 6606 |
MinKyun Na | 39 | 233 | 5004 |
Young-Chae Chang | 37 | 172 | 4838 |
In-Seon Lee | 35 | 197 | 4170 |
Hyo Seon Park | 35 | 185 | 4648 |
Beom Soo Shin | 34 | 139 | 3250 |
Kwan-Kyu Park | 33 | 153 | 3259 |
Eugene S. Kim | 32 | 126 | 3140 |