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Institution

Catholic University of the Sacred Heart

EducationMilan, Lombardia, Italy
About: Catholic University of the Sacred Heart is a education organization based out in Milan, Lombardia, Italy. It is known for research contribution in the topics: Population & Health care. The organization has 13592 authors who have published 31048 publications receiving 853961 citations.


Papers
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Journal ArticleDOI
TL;DR: In this paper, a nationwide survey of Italian acromegalic patients was conducted to describe demographic and hormonal characteristics, comorbidities (diabetes mellitus and hypertension), therapeutic procedures and their effectiveness, as well as predictors of morbidity and mortality.
Abstract: Objective: To describe demographic and hormonal characteristics, comorbidities (diabetes mellitus and hypertension), therapeutic procedures and their effectiveness, as well as predictors of morbidity and mortality in a nationwide survey of Italian acromegalic patients Design: Retrospective multicenter epidemiological study endorsed by the Italian Society of Endocrinology and performed in 24 tertiary referral Italian centers The mean follow-up time was 120 months Results: A total of 1512 patients, 41% male, mean age: 45G13 years, mean GH: 31G37 mg/l, IGF1: 744 G318 ng/ml, were included Diabetes mellitus was reported in 16% of cases and hypertension in 33% Older age and higher IGF1 levels at diagnosis were significant predictors of diabetes and hypertension At the last follow-up, 65% of patients had a controlled disease, of whom 55% were off medical therapy Observed deaths were 61, with a standardized mortality ratio of 113 95% (confidence interval (CI): 087‐146) Mortality was significantly higher in the patients with persistently active disease (193; 95% CI: 134‐270) Main causes of death were vascular diseases and malignancies with similar prevalence A multivariate analysis showed that older age, higher GH at the last follow-up, higher IGF1 levels at diagnosis, malignancy, and radiotherapy were independent predictors of mortality Conclusions: Pretreatment IGF1 levels are important predictors of morbidity and mortality in acromegaly The full hormonal control of the disease, nowadays reached in the majority of patients with modern management, reduces greatly the disease-related mortality

162 citations

Journal ArticleDOI
TL;DR: The early diagnosis of COVID-19 in health care workers, must consider, in addition to respiratory disorders and fever, anosmia, dysgeusia, exhaustion, myalgias and enteric disorders, and sleep was a significant moderating factor in the relationship between occupational stress, or organizational justice, and anxiety.
Abstract: In March-April 2020, the Corona Virus Disease 19 (COVID-19) pandemic suddenly hit Italian healthcare facilities and in some of them many staff members became infected. In this work 595 health care workers from a public company were tested for Severe acute respiratory syndrome coronavirus 2 (82 positive) and asked to complete a questionnaire on early COVID-19 symptoms. Respiratory symptoms were present in 56.1% of cases. Anosmia and dysgeusia in COVID-19 cases were found to have an odds ratio (OR) = 100.7 (95% Confidence Interval [CI] = 26.5-382.6) and an OR = 51.8 (95%CI 16.6-161.9), respectively. About one in three of the cases (29.3%) never manifested symptoms. Anxiety was reported by 16.6% of COVID-19 cases and depression by 20.3%, with a significant increase in the estimated risk (OR = 4.3; 95%CI = 2.4-7.4 for anxiety, OR = 3.5; 95%CI = 2.0-6.0 for depression). In cases, sleep was a significant moderating factor in the relationship between occupational stress, or organizational justice, and anxiety. The early diagnosis of COVID-19 in health care workers, must consider, in addition to respiratory disorders and fever, anosmia, dysgeusia, exhaustion, myalgias and enteric disorders. The frequency of anxiety and depression disorders in the population examined was not higher than that commonly recorded in the same company during periodic checks in the years preceding the epidemic. In COVID-19 cases there was a significant risk of anxiety, especially in those who had low sleep quality. Mental health support and improvement interventions must mainly concern workers with positive tests and should also tend to improve sleep quality.

162 citations

Journal ArticleDOI
TL;DR: In this paper, the effects of lorazepam and diazepam on short-interval intracortical inhibition (SICI), a motor cortical inhibition mediated through the GABAA receptor, were investigated.
Abstract: Peripheral nerve inputs have an inhibitory effect on motor cortex excitability at short intervals (short-latency afferent inhibition, SAI). This can be tested by coupling electrical stimulation of peripheral nerve with transcranial magnetic stimulation (TMS) of the motor cortex. SAI is reduced by the anticholinergic drug scopolamine, and in patients with Alzheimer's disease. Therefore, it is possible that SAI is a marker of central cholinergic activity important for memory function. The benzodiazepine lorazepam also reduces SAI. Since benzodiazepines impair memory formation, but do not do so uniformly, with a maximum amnesic effect after lorazepam but less or no effect after diazepam, we were interested in testing in this non-behavioural study to what extent the effects of lorazepam and diazepam on circuits involved in SAI could be dissociated. In addition, and for control, we tested the effects of lorazepam and diazepam on short-interval intracortical inhibition (SICI), a motor cortical inhibition mediated through the GABAA receptor. Lorazepam markedly reduced SAI, whereas diazepam slightly increased it. In contrast, both benzodiazepines uniformly increased SICI. Our findings demonstrate opposite effects of lorazepam and diazepam on SAI, an inhibition modulated by central cholinergic activity, but the same effects on SICI, a marker of neurotransmission through the GABAA receptor. This dissociation suggests, for the first time, that TMS measures of cortical inhibition provide the opportunity to segregate differences of benzodiazepine action in human central nervous system circuits.

162 citations

Journal ArticleDOI
TL;DR: A technique for minimally invasive, totally gasless video-assisted thyroid lobectomy that was accepted by a patient with a follicular nodule of the left lobe of the thyroid is developed and concluded that it is feasible and safe.
Abstract: Background: Neck surgery is one of the newest fields of application of video-assisted surgery. We developed a technique for minimally invasive, totally gasless video-assisted thyroid lobectomy. Methods: The procedure was accepted by a patient with a follicular nodule of the left lobe of the thyroid. We performed a left thyroid lobectomy through a single 20-mm horizontal skin incision, just above the sternal notch, after inserting a 5-mm 30° laparoscope, by using both endoscopic and conventional instrumentation. Results: The recurrent laryngeal nerve and the parathyroid glands were easily identified and preserved. The operating time was 2.5 hours. No complication occurred. The postoperative stay was 2 days. The cosmetic result was excellent Conclusions: We concluded that our technique is feasible and safe. This makes us optimistic about the future of minimally invasive, video-assisted thyroid surgery.

162 citations

Journal ArticleDOI
TL;DR: In this article, the authors measure the impact of wage zones on Italy's local labor markets during the 1950s using a spatial regression discontinuity design, and find that for the industrial sectors covered under wage zones there was an increase in employment when one crossed the border from a high-wage province into a low-wage one; the effect diminished as the distance from the boundary increased.
Abstract: This paper measures the impact of wage zones – minimum wage differentials at the province level – on Italy's local labor markets during the 1950s. Using a spatial regression discontinuity design, it finds that for the industrial sectors covered under wage zones there was an increase in employment when one crossed the border from a high-wage province into a low-wage one; the effect diminished, however, as the distance from the boundary increased. The paper also illustrates that the impact on the overall (non-farm) private sector, which includes both covered and uncovered sectors, was basically zero. On balance, the scheme generated some reallocation of economic activity, albeit confined to areas close to the province border.

162 citations


Authors

Showing all 13795 results

NameH-indexPapersCitations
Peter J. Barnes1941530166618
Cornelia M. van Duijn1831030146009
Dennis R. Burton16468390959
Paolo Boffetta148145593876
Massimo Antonelli130127279319
David B. Audretsch12667172456
Piero Anversa11541260220
Marco Pahor11247646549
David L. Paterson11173968485
Alfonso Caramazza10845139280
Anthony A. Amato10591157881
Stefano Pileri10063543369
Giovanni Gasbarrini9889436395
Giampaolo Merlini9668440324
Silvio Donato9686041166
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023106
2022276
20213,228
20202,935
20192,170
20181,907