scispace - formally typeset
Search or ask a question
Institution

Catholic University of the Sacred Heart

EducationMilan, Lombardia, Italy
About: Catholic University of the Sacred Heart is a education organization based out in Milan, Lombardia, Italy. It is known for research contribution in the topics: Population & Health care. The organization has 13592 authors who have published 31048 publications receiving 853961 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: The current framework provides a preliminary overview of factors which may account for PA behaviour across the life course and are most relevant to the European community.
Abstract: A large proportion of European children, adults and older adults do not engage in sufficient physical activity (PA). Understanding individual and contextual factors associated with PA behaviours is essential for the identification and implementation of effective preventative environments, policies, and programmes that can promote an active lifestyle across life course and can potentially improve health. The current paper intends to provide 1) a multi-disciplinary, Pan-European and life course view of key determinants of PA behaviours and 2) a proposal of how these factors may cluster. After gathering a list of 183 potential PA behaviours-associated factors and a consensus meeting to unify/consolidate terminology, a concept mapping software was used to collate European experts’ views of 106 identified factors for youth (<19 years), adults (19–64 years), and older adults (≥65 years). The analysis evaluated common trends in the clustering of factors and the ratings of the distinct factors’ expected modifiability and population-level impact on PA behaviours across the life course. Priority for research was also assessed for each cluster. The concept mapping resulted in six distinct clusters, broadly merged in two themes: 1) the ‘Person’, which included clusters ‘Intra-Personal Context and Wellbeing’ and ‘Family and Social Economic Status’ (42 % of all factors) and 2) the ‘Society’, which included the remaining four clusters ‘Policy and Provision’, ‘Cultural Context and Media’, ‘Social Support and Modelling’, and ‘Supportive Environment’ (58 % of all factors). Overall, 25 factors were rated as the most impactful on PA behaviours across the life course and being the most modifiable. They were mostly situated in the ‘Intra-Personal Context and Wellbeing’ cluster. Furthermore, 16 of them were rated as top priority for research. The current framework provides a preliminary overview of factors which may account for PA behaviour across the life course and are most relevant to the European community. These insights could potentially be a foundation for future Pan-European research on how these factors might interact with each other, and assist policy makers to identify appropriate interventions to maximize PA behaviours and thus the health of European citizens.

303 citations

Journal ArticleDOI
TL;DR: In this article, a large cohort of 1733 patients from Wuhan found persistent symptoms in 76% of patients 6 months after initial diagnosis of acute COVID•19, with the exception of an earlier description of five children with Long COVID in Sweden.
Abstract: There is increasing evidence that adult patients diagnosed with acute COVID‐19 suffer from Long COVID initially described in Italy. 1 A recent large cohort of 1733 patients from Wuhan found persistent symptoms in 76% of patients 6 months after initial diagnosis. 2 To date, data on Long COVID in children are scarce, with the exception of an earlier description of five children with Long COVID in Sweden. 3 We assessed persistent symptoms in paediatric patients previously diagnosed with COVID‐19.

303 citations

Journal ArticleDOI
TL;DR: The state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS) is summarized.
Abstract: Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).

302 citations

Journal ArticleDOI
TL;DR: Building on the advances achieved in the understanding of IPF pathobiology, the further investigation of the role of gene variants, epigenetic alterations and other molecular biomarkers reflecting disease activity and behaviour will hopefully enable earlier and more confident diagnosis, improve disease phenotyping and support the development of novel agents for personalized treatment of IPf.
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma, associated with significant morbidity and poor prognosis. This review will present the substantial advances achieved in the understanding of IPF pathogenesis and in the therapeutic options that can be offered to patients, and will address the issues regarding diagnosis and management that are still open. Over the last two decades much has been clarified about the pathogenic pathways underlying the development and progression of the lung scarring in IPF. Sustained alveolar epithelial micro-injury and activation has been recognised as the trigger of several biological events of disordered repair occurring in genetically susceptible ageing individuals. Despite multidisciplinary team discussion has demonstrated to increase diagnostic accuracy, patients can still remain unclassified when the current diagnostic criteria are strictly applied, requiring the identification of a Usual Interstitial Pattern either on high-resolution computed tomography scan or lung biopsy. Outstanding achievements have been made in the management of these patients, as nintedanib and pirfenidone consistently proved to reduce the rate of progression of the fibrotic process. However, many uncertainties still lie in the correct use of these drugs, ranging from the initial choice of the drug, the appropriate timing for treatment and the benefit-risk ratio of a combined treatment regimen. Several novel compounds are being developed in the perspective of a more targeted therapeutic approach; in the meantime, the supportive care of these patients and their carers should be appropriately prioritized, and greater efforts should be made toward the prompt identification and management of relevant comorbidities. Building on the advances in the understanding of IPF pathobiology, the further investigation of the role of gene variants, epigenetic alterations and other molecular biomarkers reflecting disease activity and behaviour will hopefully enable earlier and more confident diagnosis, improve disease phenotyping and support the development of novel agents for personalized treatment of IPF.

302 citations

Journal ArticleDOI
TL;DR: The present document provides a reporting scheme for thyroidcytology and the suggested clinical actions and is not meant to address in detail all the morphological features of thyroid cytology.
Abstract: IntroductionThyroid nodules are diagnosed with increasing frequencyin clinical practice. The first step in the management ofpatients presenting with thyroid nodules is an accuratetriage of those who should be referred to surgery [1–5]. Inspite of the advances in ultrasound (US) imaging [6–8] andthe promising results of molecular analysis [9–16], thisbasic step still strongly relies on cytology [3]. Among theacronyms used to indicate the sampling technique forthyroid cytology (FNA, FNAB, FNAC, FNC), fine-needleaspiration (FNA) is the most frequently adopted and it willbe employed in this document. When the cytologicspecimen is obtained without aspiration the term FNC(fine-needle cytology) may be used [2].In the recent years, a variety of four- to six-tieredreporting schemes for thyroid cytology have been proposedby different societies and institutions, with the aim ofimproving the communication between cytopathologistsand clinicians [17].With the aim to standardize the diagnostic terminologyin thyroid FNA, in 2007 the United States National CancerInstitute (NCI) has proposed a reporting system for thyroidcytology based on the NCI Thyroid FNA State-Of-ScienceConsensus Conference [18]. This system has gained widediffusion and the atlas ‘‘The Bethesda System for Report-ing Thyroid Cytology’’ (BSRTC) provided well-definedcriteria with exhaustive explanatory notes [19]. Followingthe recommendations of the 2009 European Federation ofCytology Societies (EFCS) symposium aiming at theworldwide unification of the reporting systems for thyroidcytology [20], a working group of the Royal College ofPathologists (RCPath) updated the reporting systemalready in use in UK since 2007 [21] using criteria that aresimilar to those used in BSRTC [22].In Italy, a 5-tiered classification, proposed in 2007 bythe Italian Society for Anatomic Pathology and Cytologyjoint with the Italian Division of the International Academyof Pathology (SIAPEC-IAP) [2], is currently used by mostinstitutions. In 2012 the Italian Societies of Endocrinology,i.e., the Italian Thyroid Association (AIT), the ItalianAssociation of Clinical Endocrinologists (AME), the Ital-ian Society of Endocrinology (SIE) and the SIAPEC-IAPappointed a working panel of experts to update the formerconsensus in line with the indications of the EFCS. Thepresent document provides a reporting scheme for thyroidcytology and the suggested clinical actions. This Consen-sus is not meant to address in detail all the morphological

301 citations


Authors

Showing all 13795 results

NameH-indexPapersCitations
Peter J. Barnes1941530166618
Cornelia M. van Duijn1831030146009
Dennis R. Burton16468390959
Paolo Boffetta148145593876
Massimo Antonelli130127279319
David B. Audretsch12667172456
Piero Anversa11541260220
Marco Pahor11247646549
David L. Paterson11173968485
Alfonso Caramazza10845139280
Anthony A. Amato10591157881
Stefano Pileri10063543369
Giovanni Gasbarrini9889436395
Giampaolo Merlini9668440324
Silvio Donato9686041166
Network Information
Related Institutions (5)
University of Turin
77.9K papers, 2.4M citations

95% related

University of Milan
139.7K papers, 4.6M citations

94% related

Sapienza University of Rome
155.4K papers, 4.3M citations

93% related

University of Florence
79.5K papers, 2.3M citations

93% related

University of Bologna
115.1K papers, 3.4M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023106
2022276
20213,228
20202,935
20192,170
20181,907