Institution
Cayetano Heredia University
Education•Lima, Peru•
About: Cayetano Heredia University is a education organization based out in Lima, Peru. It is known for research contribution in the topics: Population & Taenia solium. The organization has 6152 authors who have published 7768 publications receiving 183598 citations. The organization is also known as: Universidad Peruana Cayetano Heredia & UPCH.
Papers published on a yearly basis
Papers
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TL;DR: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and has reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-generation sequencing, deep exome sequencing, and dense microarray genotyping.
Abstract: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies.
12,661 citations
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Harvard University1, China Medical Board2, Aga Khan University3, Washington University in St. Louis4, Cayetano Heredia University5, Peking University6, National Health Laboratory Service7, University of Pennsylvania8, University of Toronto9, Rockefeller Foundation10, Public Health Foundation of India11, The Sage Colleges12, Bill & Melinda Gates Foundation13, Makerere University14, American University of Beirut15
TL;DR: In this article, the authors present a comprehensive framework that considers the connections between education and health systems, centred on people as co-producers and as drivers of needs and demands in both systems.
4,215 citations
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Mariachiara Di Cesare1, Mariachiara Di Cesare2, James Bentham1, Gretchen A Stevens3 +738 more•Institutions (60)
TL;DR: The posterior probability of meeting the target of halting by 2025 the rise in obesity at its 2010 levels, if post-2000 trends continue, is calculated.
3,766 citations
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TL;DR: In this article, the authors used a Bayesian hierarchical model to estimate trends in diabetes prevalence, defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs in 200 countries and territories in 21 regions, by sex and from 1980 to 2014.
2,782 citations
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TL;DR: The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease.
Abstract: In the past decade, leptospirosis has emerged as a globally important infectious disease. It occurs in urban environments of industrialised and developing countries, as well as in rural regions worldwide. Mortality remains significant, related both to delays in diagnosis due to lack of infrastructure and adequate clinical suspicion, and to other poorly understood reasons that may include inherent pathogenicity of some leptospiral strains or genetically determined host immunopathological responses. Pulmonary haemorrhage is recognised increasingly as a major, often lethal, manifestation of leptospirosis, the pathogenesis of which remains unclear. The completion of the genome sequence of Leptospira interrogans serovar lai, and other continuing leptospiral genome sequencing projects, promise to guide future work on the disease. Mainstays of treatment are still tetracyclines and beta-lactam/cephalosporins. No vaccine is available. Prevention is largely dependent on sanitation measures that may be difficult to implement, especially in developing countries.
2,055 citations
Authors
Showing all 6180 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gordon H. Guyatt | 231 | 1620 | 228631 |
Carlos Bustamante | 161 | 770 | 106053 |
Richard J. Johnson | 137 | 880 | 72201 |
Victor M. Montori | 131 | 711 | 78867 |
Liam Smeeth | 104 | 753 | 53433 |
Robert H. Gilman | 96 | 903 | 43750 |
Graciela S. Alarcón | 94 | 641 | 43254 |
Michael J. Levy | 94 | 1029 | 37843 |
Thomas J. Coates | 91 | 415 | 28878 |
Diane E. Griffin | 88 | 397 | 25137 |
Italo Biaggioni | 81 | 377 | 21886 |
David A. Sack | 80 | 437 | 23320 |
Paul E. Goss | 79 | 377 | 26502 |
Max Gassmann | 76 | 321 | 23115 |
Rosanna W. Peeling | 75 | 332 | 21465 |