Showing papers by "Celal Bayar University published in 2001"
TL;DR: In this article, the non-linear vibrations of an axially moving beam are investigated by including the stretching effect of the beam, where the beam is moving with a time-dependent velocity, namely a harmonically varying velocity about a constant mean velocity.
Abstract: Non-linear vibrations of an axially moving beam are investigated. The non-linearity is introduced by including stretching effect of the beam. The beam is moving with a time-dependent velocity, namely a harmonically varying velocity about a constant mean velocity. Approximate solutions are sought using the method of multiple scales. Depending on the variation of velocity, three distinct cases arise: (i) frequency away from zero or two times the natural frequency, (ii) frequency close to zero, (iii) frequency close to two times the natural frequency. Amplitude-dependent non-linear frequencies are derived. For frequencies close to two times the natural frequency, stability and bifurcations of steady-state solutions are analyzed. For frequencies close to zero, it is shown that the amplitudes are bounded in time.
207 citations
TL;DR: In this paper, the physical and chemical properties of colemanite waste from concentrator, coal bottom ash, fly ash, cement+ash mixtures, and their effects on the mechanical properties of concrete were investigated.
121 citations
TL;DR: In this paper, a polyphenoloxidase (PPO) of peppermint leaves ( Mentha piperita) was isolated by (NH4)2SO4 precipitation and dialysis and its pH and temperature optima were 7.0 and 30°C, respectively.
94 citations
TL;DR: An unusual case of primary intramuscular hydatidosis with its magnetic resonance imaging appearance, clinical and pathological findings is reported.
Abstract: Hydatid disease of the muscle is very rare and represents approximately 3% of all patients with hydatidosis. Since the infection closely resembles a soft-tissue tumor on clinical examination, the preoperative radiologic diagnosis is very important to avoid biopsy. We report an unusual case of primary intramuscular hydatidosis with its magnetic resonance imaging appearance, clinical and pathological findings.
84 citations
TL;DR: In this paper, two-dimensional equations of motion for the slowly flowing second grade fluid are written in cartesian coordinates neglecting the inertial terms, by employing Lie group analysis, the symmetries of the equations are calculated.
Abstract: The two-dimensional equations of motion for the slowly flowing second grade fluid are written in cartesian coordinates neglecting the inertial terms. By employing Lie group analysis, the symmetries of the equations are calculated. The Lie algebra consists of four finite parameter Lie group transformations, one being the scaling symmetry and the others being translations. Two different types of solutions are found using the symmetries. Using the translations in x and y coordinates, an exponential type of exact solution is constructed. For the scaling symmetry, the outcoming ordinary differential equations are more involved and only a series type of approximate solution is presented. Finally, some boundary value problems are discussed.
70 citations
TL;DR: Intraoperative single‐dose application of EDTA, EDTA+RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes.
Abstract: Purpose: To determine whether an intraoperative single dose of dexamethasone, diclofenac, ethylenediaminetetraacetic acid (EDTA), a combination of EDTA and RGD peptide (arginine-glycin-aspartic acid sequence), or mitomycin-C (MMC) is a pharmacological means of preventing or reducing the development of posterior capsule opacification (PCO). Setting: Department of Ophthalmology, Celal Bayar University, School of Medicine, Manisa, and Department of Pathology, Dokur Eylul University, School of Medicine, Izmir, Turkey. Methods: Fifty-four rabbits were randomly divided into 6 groups. Dexamethasone (4 mg/cc), diclofenac (2.5 mg/cc), EDTA (8 mg/cc), a combination of EDTA and RGD peptide (2.5 mg/cc), or MMC (0.04 mg/cc) was given, 0.1 cc by hydrodissection and 0.9 cc into the capsular bag after phacoemulsification. The sixth group served as a control group. After 3 months, the PCO was graded clinically and the proliferation of lens epithelial cells (LECs) was evaluated histologically. Results: The drugs were significantly effective in preventing PCO compared with the control ( P Conclusions: Intraoperative single-dose application of EDTA, EDTA+RGD peptide combination, and MMC significantly prevented the development of PCO in rabbit eyes. Diclofenac was less effective but also reduced PCO. Although dexamethasone did not prevent the proliferation of LECs, it decreased PCO clinically.
69 citations
TL;DR: The results of this study suggested that the activities of GSH-PX, GR and GST did not depend and GST activities overall were higher in females, which implies that each population should determine its own reference values and should investigate the influence of environmental factors and life style habits on these enzymes.
60 citations
TL;DR: In this article, the authors investigated the non-linear transverse vibrations of highly tensioned pipes with vanishing flexural stiffness and conveying fluid with variable velocity, where the velocity is assumed to be a harmonic function about a mean velocity.
Abstract: In this study, the non-linear transverse vibrations of highly tensioned pipes with vanishing flexural stiffness and conveying fluid with variable velocity are investigated. The pipe is on fixed supports and the immovable end conditions result in the extension of the pipe during vibration and hence introduce further non-linear terms to the equation of motion. The velocity is assumed to be a harmonic function about a mean velocity. These systems experience a Coriolis acceleration component which renders such systems gyroscopic. The equation of motion is solved analytically by direct application of the method of multiple scales (a perturbation technique). Principal parametric resonance cases are investigated in detail. Non-linear frequencies are derived depending on amplitude. For frequencies close to two times the natural frequency, stability and bifurcations of steady-state solutions are analyzed. For frequencies close to zero, it is shown that the amplitudes are bounded in time.
58 citations
TL;DR: All are invited for a 3-day symposium, Àdvances in Medical and Surgical Dermatology', to be held 79± December 2001 in New York, USA, with prizes of $500, $250 and $100 will be awarded for the best three poster abstracts.
Abstract: s are invited for a 3-day symposium, Àdvances in Medical and Surgical Dermatology', to be held 79± December 2001 in New York, USA. Closing date for abstracts is 1 November, 2001. The timetable for the meeting is as follows: Friday December 7: Surgical meeting. Cutting edge lectures on all aspects of surgical and cosmetic dermatology: Saturday December 8: Live patient demonstrations of filler substances, Botox, laser treatments. Scientific meeting lectures by leaders in dermatological research. Prizes of $500, $250 and $100 will be awarded for the best three poster abstracts. Sunday December 9: Medical meeting. State-of-the-art lectures on psoriasis, atopic dermatitis, STDs, skin manifestations of HIV, topical immunomodulators, contact dermatitis. Reduced registration fee available for dermatologists outside of north America. Further information can be obtained from: http://www.mssm.edu/dermatology/symposium2001, or by contacting Donald Rudikoff MID, email: RNAhybrid(a)aol.com British Skin Foundation 2001 Awards: Call for Grant Applications The Trustees of the British Skin Foundation wish to announce that funding is again available for skin disease research. This year there are four categories of award as listed below. Applicants are asked to apply for funding from the category that they feel is most appropriate. The closing date is 17th September 2001. BSF Research Awards: Oneor 2-year project grants of up to £50,000 per annum. The BSF Fellowship: A grant of £40,000 to support a specialist registrar in dermatology through one year of research. Candidates should submit details of their proposed research and a C.V. in the manner described below. Selection will be by interview in late 2001. It is envisaged that the successful candidate will already hold an NTN or will have just completed their training. BSF Small Grant Awards: One-off payments of up to £10,000. May be used to purchase equipment or for less costly projects. BSF Studentship: A 3-year package, value £44,000, covering tuition fees, expenses and some consumables. If you wish to receive an application form for a British Skin Foundation grant, please contact the office, specifying the type of grant you are interested in at: British Skin Foundation, 19 Fitzroy Square, London WIT 6EH, U.K. Tel: 20 7383 0266; fax: 7388 5263. NEWS AND NOTICES 373
54 citations
TL;DR: This is the first article describing organized hematoma in the maxillary sinus mimicking tumor without bleeding history and disorders, and it is presented as a provisional diagnosis when a patient with history of epistaxis develops a slow-growing mass of the cheek and/or nasal obstruction.
42 citations
TL;DR: It is concluded that lacrimal drainage system injury might occur in various extents during functional endoscopic sinus surgery, however, it does not necessarily result in postoperative epiphora.
Abstract: In order to evaluate the lacrimal drainage system injury after functional endoscopic sinus surgery, surgical records and postoperative active transport dacryocystography imaging of 31 patients were analyzed. Presence of the lacrimal bone dehiscence and no passage of the contrast material into the inferior meatus were noted as the signs of injury to the lacrimal canal on active transport dacryocystography. Bony dehiscence was detected in 53.2% of the operated sides but 20% of the nonoperated sides. No passage of the contrast material into the inferior meatus was observed in 14.9% of the operated sides. There were no cases of epiphora postoperatively. The lacrimal drainage system injury was more frequently observed on the left sides operated. We conclude that lacrimal drainage system injury might occur in various extents during functional endoscopic sinus surgery. However, it does not necessarily result in postoperative epiphora. Performing the middle meatal antrostomy in posteroinferior direction, and uncinectomy with backbiting forceps or a shaver might help in reducing the lacrimal injury. Active transport dacryocystography can be adopted as an alternative diagnostic tool in detection of the lacrimal injury. (Otolaryngol Head Neck Surg 2001;124:308-12.)
TL;DR: In this paper, the presence of copper nanoparticles in alumina and silica modifies their luminescence, and the changes in spectra are influenced by variations in the nanoparticle size distributions.
Abstract: The presence of copper nanoparticles in alumina and silica modifies their luminescence, and the changes in spectra are influenced by variations in the nanoparticle size distributions. Luminescence signals are sensitive to the total defect population. Thus the luminescence not only reflects changes caused by thermal annealing, which can modify both intrinsic defects and the copper nanoparticles, but also responds to the method of preparation of thin film layers. Copper nanoparticle influence on luminescence is reported both for ion-implanted bulk silica and for copper in pulsed laser deposition within alumina. Luminescence thus potentially offers a non-destructive monitor of the layer quality, reproducibility and growth conditions, as well as the state and size of the copper nanoparticles.
TL;DR: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes, and the optimal biocompatible dosage must be carefully determined by further investigation.
Abstract: Background: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 µg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multilayer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation.
Journal Article•
TL;DR: It is considered that in selected cases the dissection might be carried out laterally from the sphenoid ostium for safe enlargement of the ostium and approaching the sinus, and the lateral distance was about the distance between both ostea.
Abstract: Endoscopic surgery of the sphenoid sinus can present the operator with a considerable challenge. The relationship of the sphenoid sinuses, in particular on the lateral wall, to the carotid artery, optic nerve, as well as the other anatomic structures, is of utmost importance. Surgical complications can occur because of a lack of orientation during dissection. To avoid the complications or lessen, somehow, the rate of complications, some described the technique consisting of the opening of the sphenoid sinus ostium medially. We studied 69 axial high resolution computed tomography (HRCT) of temporal bones to reveal the relationship of sphenoid sinus to the vital structures and to get some measurements in the sphenoid sinus. The lateral distance from the sphenoid ostium revealed that the lateral distance was about the distance between both ostea. We consider that in selected cases the dissection might be carried out laterally from the sphenoid ostium for safe enlargement of the ostium and approaching the sinus.
TL;DR: Good spontaneous smile and sufficient depressor mechanism were achieved by cross-f facial nerve grafting and hypoglossal-facial nerve crossover respectively, and these techniques are demonstrated by the authors clinically and electrophysiologically.
Abstract: Reanimation of a spontaneous and synchronous smile, and sufficient depressor mechanism of the lower lip presents a surgical challenge in facial paralysis. Hypoglossal-facial nerve crossover and cross-facial nerve grafting are the best options if the mimetic muscles around the mouth are still viable in patients in whom the facial nerve was sacrificed at the brainstem. Although good muscle tone and facial motion have been obtained by hypoglossal-facial nerve crossover, smile is dependent on conscious tongue movement. Cross-facial nerve grafting provides a voluntary and emotion-driven smile, but requires two coaptation sites, which leads to substantial axonal loss and a long regeneration time. This method was not successful in activating the depressor mechanism. The first stage is the classic "baby-sitting" procedure, in which the bulk of the mimetic muscles was maintained by the rapid reinnervation of the hypoglossal-facial nerve crossover during the regeneration period of the cross-facial nerve graft, and temporalis muscle transfer to the eyelids is performed. During the second stage, the cross-facial nerve graft that used the thickest zygomaticobuccal branch on the healthy side was coapted with the corresponding branches on the paralyzed side. The hypoglossal-facial nerve crossover continued to innervate the depressor muscles. Good spontaneous smile and sufficient depressor mechanism were achieved by cross-facial nerve grafting and hypoglossal-facial nerve crossover respectively, and these techniques are demonstrated by the authors clinically and electrophysiologically.
TL;DR: In this article, the power law model described the pseudoplastic behaviour of boza and the consistency (k) and flow behaviour index (n) of fermented and unfermented boza samples were significantly different from each other at 10, 20 and 30 °C.
Abstract: Boza was prepared with corn, rice and wheat flour. Alterations in pH, water-soluble protein content and viscosity were observed during a 30 h fermentation period. Fermentation caused a reduction in pH, whereas the water-soluble protein content of boza significantly increased (P<0.05). The power law model described the pseudoplastic behaviour of boza. The consistency (k) and flow behaviour index (n) values indicated that the viscosity of boza decreases as the temperature increases. The k values of fermented and unfermented boza samples were significantly (P<0.05) different from each other at 10, 20 and 30 °C. The n values of unfermented boza did not vary significantly with temperature whereas n values of fermented boza changed significantly.
TL;DR: A child (8 years old) with a gigantic mass of intracranial hydatid cysts (95×90×75 mm) is presented, and a craniotomy was performed, and more than 25 cysts were removed.
Abstract: A child (8 years old) with a gigantic mass of intracranial hydatid cysts (95×90×75 mm) is presented. The first manifestation was difficulty in walking, which was followed by symptoms of raised intracranial pressure. A craniotomy was performed, and more than 25 hydatid cysts were removed. The literature is reviewed and the incidence of gigantic mass of cerebral hydatid cyst is compared in the published reports.
TL;DR: The microsurgical anatomy of the jugular foramen was studied in 12 formalin preserved cadavers and 40 dry-skulls and related terminology is discussed in the light of a literature review.
TL;DR: Surgical anatomical relationships of the facial nerve with several landmarks used in mastoid surgery were studied in temporal bone axial high resolution CT scans of 90 patients and FN–EAC was found to be longer in poorly pneumatized bones whereas other distances were longer in pneumatizing bones.
Abstract: Surgical anatomical relationships of the facial nerve (FN) with several landmarks used in mastoid surgery were studied in temporal bone axial high resolution CT scans of 90 patients (180 ears). The shortest distances between the FN and external auditory canal (EAC), sigmoid sinus (SS), posterior fossa dural plate (PFD), and joint of the bony EAC with the lateral surface of the mastoid (M) were measured. These measurements were also analysed in respect of pneumatization and side differences. On average, it was found that FN-EAC was 2.9 mm, FN-SS was 10.5 mm, FN-PFD was 7.3 mm and FN-M was 15.3 mm. FN-EAC was found to be longer in poorly pneumatized bones whereas other distances were longer in pneumatized bones. FN-M was found to be longer on the right side.
TL;DR: In this paper, the operator notation was further generalized to model a system with an arbitrary number of coupled differential equations, where linear parts of the equations are expressed with linear differential and/or integral operators, and non-linear parts with arbitrary quadratic and cubic operators.
TL;DR: Investigation of the electrochemical behavior of timolol maleate on a mercury drop electrode reveals the presence of a specific reduction peak of analytical significance, which is suitable for routine analysis and requires no preconcentration step for the analysis of therapeutic doses of the drug.
Abstract: Timolol as a β-adrenoceptor antagonist is a potent antihypertensive and antianginal drug, which was also proved to be effective for the secondary prevention of myocardial infarction. The analysis of timolol, as with other oxprenolols, in ophthalmic solutions and biological liquids using sensitive instrumental methods has gained importance. Investigation of the electrochemical behavior of timolol maleate on a mercury drop electrode reveals the presence of a specific reduction peak of analytical significance. Analysis conditions affecting the properties of this peak were optimized by a systematic study. The limit of detection of about 2.5 ppb, obtained for the DPV technique using SMDE, is comparable with the most sensitive techniques. This method is suitable for routine analysis in that it is simpler and requires no preconcentration step for the analysis of therapeutic doses of the drug.
TL;DR: The purification and characterization of catalase from chard is reported, indicating that the chardCatalase is a tetramer and the purified protein has a broad pH optimum for catal enzyme activity between 6.0 and 8.0.
Abstract: Catalase is a major primary antioxidant defence component that primarily catalyses the decomposition of H(2) O(2) to H(2) O. Here we report the purification and characterization of catalase from chard (Beta vulgaris var. cicla). Following a procedure that involved chloroform treatment, ammonium sulfate precipitation and three chromatographic steps (CM-cellulose, Sephadex G-25, and Sephadex G-200), catalase was purified about 250-fold to a final specific activity of 56947 U/mg of protein. The molecular weight of the purified catalase and its subunit were determined to be 235 000 and 58 500 daltons, indicating that the chard catalase is a tetramer. The absorption spectra showed a soret peak at 406 nm, and there was slightly reduction by dithionite. The ratio of absorption at 406 and 275 nanometers was 1.5, the value being similar to that obtained for catalase from other plant sources. In the catalytic reaction, the apparent Km value for chard catalase was 50 mM. The purified protein has a broad pH optimum for catalase activity between 6.0 and 8.0. The enzyme had an optimum reaction temperature at 30 degrees C. Heme catalase inhibitors, such as azide and cyanide, inhibited the enzyme activity markedly and the enzyme was also inactivated by ?-mercaptoethanol, dithiothreitol and iodoacetamide.
TL;DR: Although CH has a bitter taste and is a gastric irritant for oral medication, it remains as a safe and successful drug for use in children for TTE because of the minimal side effects and efficacy for sedation.
Abstract: Transthoracic echocardiography (TTE) is a painless, noninvasive and risk-free diagnostic method in children with known or suspected congenital heart disease. Sedation is frequently required for an optimal achievement of this procedure. The purpose of this study was to determine the safety and efficacy of chloral hydrate (CH) sedation in undergoing TTE. The study population included 360 patients with a median age of 19 months. (2 weeks to 8 years). The median dosage of CH given was 75 mg/kg (ranging 50 and 100 mg), with either oral or rectal administration. Oral administration could not be achieved successfully in 90 patients (20%) because of the bitter taste of the drug, in the other 108 patients (30%), vomiting occurred immediately after drug administration. Prior to CH administration and until discharge; respiratory rate; heart rate, blood pressure and oxygen saturation were recorded. Sedation was successfully achieved in 342 (95%) of the patients. No child had a clinically significant change in heart rate, blood pressure and respiratory rate during sedation. There were also no significant differences in heart rate, respiratory rate, blood pressure and oxygen saturation before and after sedation. Although CH has a bitter taste and is a gastric irritant for oral medication, because of the minimal side effects and efficacy for sedation, it remains as a safe and successful drug for use in children for TTE.
TL;DR: In this paper, the authors encountered 9 cases of tuberculosis out of 157 chronic HD patients in 36 months, including four pulmonary, four lymph nodal and one isolated dermal involvement.
Abstract: We encountered 9 cases of tuberculosis out of our 157 chronic HD patients in 36 months. Four pulmonary, 4 lymph nodal and one isolated dermal involvement were detected. Therapy was commenced without waiting for absolute cultural or pathologic diagnosis because of the high index of clinical suspicion. All cases except one recovered completely. Among associated conditions, peptic ulcer disease, anti-HCV positivity, and diabetes mellitus were noted, though the last two did not reach statistical significance. Prompt institution of the specific therapy and close supervision of the cases during treatment enabled us to obtain a cure in all cases except one and to discern adverse drug effects immediately and to make appropriate changes in the therapy. Thus, no morbidity due to the disease itself or drugs was observed.
TL;DR: Balb/c mice are a suitable laboratory model for this isolate of L. tropica and thus a source of amastigotes for studies on the immunology, chemotherapy, and pathogenicity of cutaneous leishmaniasis.
Abstract: Leishmania tropica, which is endemic in Turkey, is the causative agent of cutaneous leishmaniasis. Leishmania tropica promastigotes (2 × 107) isolated from a patient with dermal leishmaniasis and reproduced in NNN medium were inoculated subcutaneously into the footpads of 10 Balb/c mice. Cutaneous leishmaniasis developed on the footpads of 4 mice approximately 45 days later. Leishmania tropica amastigotes were observed in smear slides and then cultivated in NNN medium. Balb/c mice are a suitable laboratory model for this isolate of L. tropica and thus a source of amastigotes for studies on the immunology, chemotherapy, and pathogenicity of cutaneous leishmaniasis.
TL;DR: It is indicated that clomiphene citrate treatment significantly decreased the endometrial thickness and increased oestradiol and progesterone concentrations, however, secretion of alpha(v), beta1 and alpha3 integrin molecules, which might play a role in implantation, was not affected.
Abstract: BACKGROUND The expression of integrin molecules on the endometrium suggests that certain integrins may participate in the cascade of molecular events leading to successful implantation. A prospective, controlled study was carried out to investigate the effect of clomiphene citrate (CC) on secretions of beta1, alpha3 and alphaV integrin molecules in the endometrium of patients with unexplained infertility during the implantation window. METHODS A total of 40 endometrial samples was evaluated in both spontaneous (n = 13) and ensuing clomiphene-treated cycles (100 mg on days 5-9) and also from fertile women serving as controls (n = 14) during postovulatory 7th or 8th day of menstrual cycle. A semiquantitative grading system (H-score) was used to compare the immunohistochemical staining intensities. Endometrial thickness and serum oestradiol and progesterone concentrations were also measured on the day of sampling. RESULTS Staining of alpha(v) but not beta1 and alpha3 integrins was significantly less intense in infertile cases than fertile control cases (1.42 +/- 0.12 versus 2.21 +/- 0.13 respectively, P = 0.012) and this was not restored to normal concentrations with treatment. CONCLUSIONS Our study indicated that cc treatment significantly decreased the endometrial thickness and increased oestradiol and progesterone concentrations. However, secretion of alpha(v), beta1 and alpha3 integrin molecules, which might play a role in implantation, was not affected.
TL;DR: A 69‐year‐old man who developed a blue–black nodular lesion with satellitosis mimicking malignant melanoma with no cellular atypia and mitotic activity is reported, which is the third reported case of a blue naevus with satellites mimickingmalignant melanomas.
Abstract: Blue naevus is an acquired benign melanocytic naevus. It is a firm, sharply defined dark blue to grey-black papule or nodule, which is likely to arise from the arrested dermal melanocytes in the dermis. In the last few years, blue naevus has attracted much attention due to the recognition of new entities and to its confusion with malignant melanoma. We report a 69-year-old man who developed a blue-black nodular lesion with satellitosis on his scalp. Although clinically it was thought to be a malignant melanoma, histopathological investigation and conservative methods such as dermatoscopy and power Doppler ultrasonography did not confirm this diagnosis. Histopathological examination excluded malignant melanoma, as there were no cellular atypia and mitotic activity in either the nodular lesion or the satellitosis. Doppler ultrasonography confirmed the benign nature of the lesion. Dermatoscopic examination showed homogeneous steel-blue pigmentation with individual blue globules, dots and some brown veils, and confirmed the histopathological diagnosis. To the best of our knowledge, our case is the third reported case of a blue naevus with satellitosis mimicking malignant melanoma.
TL;DR: The aim of this study was to investigate the effect of interferon‐α to 2b and octreotide on the treatment of esophagus corrosive burns.
Abstract: Objective The aim of this study was to investigate the effect of interferon-α to 2b and octreotide on the treatment of esophagus corrosive burns.
Method The experimental study was performed on 63 rabbits. Burn was obtained by treating a segment, isolated in cervical esophagus, with NAOH. The rabbits were allocated into three groups (control, interferon, and octreotide). On the fourth, eighth, and 20th days, 7 rabbits randomly selected from each group were killed. Comparisons among the groups were made by taking histopathologic findings, stenosis index, and hydroxyproline production into consideration. Cross-tabulation and analysis of variance tests were used for statistical analysis.
Results There were no statistically significant differences among the groups in terms of epithelial changes, extension of inflammation, and severity of fibrosis. In terms of severity of inflammation, there was a statistically significant difference between the control and the other two groups. Also, a significant difference was found between the control group and the other two groups in terms of extension of fibrosis on the 20th day. The difference between the control and the two treatment groups was significant on the eighth day and the 20th day measurements. Comparison of the hydroxyproline values showed a statistically significant difference between the octreotide group and the other two groups on the eighth and 20th days.
Conclusion Histopathologic and biochemical findings indicate that, by hindering fibrosis progress, octreotide (and interferon) might be new and promising alternatives in the treatment of corrosive burns of the esophagus.
TL;DR: The findings revealed that CagA-negative status might be a risk factor for failure of H. pylori triple therapies, and has been associated with an increase in the inflammatory response at the gastric mucosal level.
Abstract: If cytotoxin-associated gene A (CagA) status affects the response rates of therapy, then it may be possible to predict Helicobacter pylori eradication rates. We aimed to evaluate the response to eradication treatment of H. pylori infection in CagA-positive and CagA-negative patients. A total of 184 patients (93 males, 91 females, mean age 42.6 ± 12.8 years) with H. pylori-positive chronic gastritis were studied. Subjects underwent a gastroscopy and biopsy specimens were taken from the gastric antrum, body, and fundus. Before the eradication therapy was given all patients were tested for CagA, TNF-a and gastrin levels. They were then prescribed lansoprazole (30 mg bid), clarithromycin (500 mg bid), and amoxicillin (1.0 mg bid) for one week. On the 8th week a second endoscopy was performed and further biopsy specimens were obtained from the same sites as in the initial endoscopy. One hundred and twenty-seven patients (69.1%) were found to be CagA positive and 57 patients (30.9%) were CagA negative. The total eradication rate was 82.6%. In the CagA-positive group this rate was 87.4%, and in the CagA-negative group it was 71.9% (P = 0.019). TNF-a levels were higher in the CagA-positive than in the CagA-negative group (P = 0.001). However, gastrin levels were not different between groups (P = 0.421). Our findings revealed that CagA-negative status might be a risk factor for failure of H. pylori triple therapies. The CagA pathogenicity island gives a growth advantage to H. pylori strains and has been associated with an increase in the inflammatory response at the gastric mucosal level. These properties could make CagA-positive H. pylori strains more susceptible to antibiotics.
TL;DR: It is suggested that 99mTc-IgG scintigraphy is a reliable and objective method in detecting synovial activity and can be appropriate for observing disease prognosis in clinical trials with RA.
Abstract: The aim of this study was to investigate whether 99mtechnetium-labelled polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy reflects synovial inflammation in patients with rheumatoid arthritis (RA). We evaluated 29 patients with RA for this reason and found a highly significant correlation between total scintigraphic scores and total tenderness scores (r=0.781, P 0.05). The correlation between disease activity scores and total scintigraphic scores was also found to be significant (r=0.812, P < 0.001). We suggest that 99mTc-IgG scintigraphy is a reliable and objective method in detecting synovial activity and can be appropriate for observing disease prognosis in clinical trials with RA.