Celal Bayar University

About: Celal Bayar University is a education organization based out in Magnesia ad Sipylum, Turkey. It is known for research contribution in the topics: Population & Heat transfer. The organization has 2960 authors who have published 6024 publications receiving 100646 citations.

Predicting Technology Integration Based on a Conceptual Framework for ICT Use in Education.

Abstract: The purpose of this study is twofold: (1) to propose a conceptual framework for classifying ICT use in education and (2) to develop and test a structural model including both teacher- and s...

Nonlinear free and forced vibration analyses of axially functionally graded Euler-Bernoulli beams with non-uniform cross-section

Abstract: Nonlinear free and forced vibrations of axially functionally graded Euler-Bernoulli beams with non-uniform cross-section are investigated. The beam has immovable, namely clamped-clamped and pinned-pinned boundary conditions, which leads to midplane stretching in the course of vibrations. Nonlinearities occur in the system due to this stretching. Damping and forcing terms are included after nondimensionalization. The equations are solved approximately using perturbation method and mode shapes by differential quadrature method. In the linear order natural frequencies and mode shapes are computed. In the nonlinear order, some corrections arise to the linear problem; the effect of these nonlinear correction terms on natural frequency is examined and frequency –response curves are drawn to show the unstable regions. In order to confirm the validity, our results are compared with others available in literature.

Resveratrol induces mitochondria-mediated, caspase-independent apoptosis in murine prostate cancer cells.

Abstract: Found in the skins of red fruits, including grapes, resveratrol (RES) is a polyphenolic compound with cancer chemopreventive activity. Because of this activity, it has gained interest for scientific investigations. RES inhibits tumor growth and progression by targeting mitochondria-dependent or -independent pathways. However, further investigations are needed to explore the underlying mechanisms.The present study is focused on examining the role of RES-induced, mitochondria-mediated, caspase-independent apoptosis of prostate cancer cells, namely transgenic adenocarcinoma of mouse prostate (TRAMP) cells. These cells were exposed to RES for various times, and cell killing, cell morphology, mitochondrial membrane potential (Δψm), expression of Bax and Bcl2 proteins, the role of caspase-3, and DNA fragmentation were analyzed.TRAMP cells exposed to RES showed decreased cell viability, altered cell morphology, and disrupted Δψm, which led to aberrant expression of Bax and Bcl2 proteins. Furthermore, since the caspase-3 inhibitor, z-VAD-fmk (benzyloxycarbonyl-valine-alanine-aspartic acid-fluoromethyl ketone), had no appreciable impact on RES-induced cell killing, the killing was evidently caspase-independent. In addition, RES treatment of TRAMP-C1, TRAMP-C2, and TRAMP-C3 cells caused an appreciable breakage of genomic DNA into low-molecular-weight fragments.These findings show that, in inhibition of proliferation of TRAMP cells, RES induces mitochondria-mediated, caspase-independent apoptosis. Therefore, RES may be utilized as a therapeutic agent to control the proliferation and growth of cancer cells.