Celal Bayar University

About: Celal Bayar University is a education organization based out in Magnesia ad Sipylum, Turkey. It is known for research contribution in the topics: Population & Heat transfer. The organization has 2960 authors who have published 6024 publications receiving 100646 citations.

Serum tumor growth factor‐β1 levels in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C

Abstract: Chronic liver disease and cirrhosis are two of the most important health problems according to current gastroenterology literature. Based on the recent developments in the field of immunology, advanced follow-up and treatment modalities have been introduced for these disorders. Immune defence against viral infections depends on effective cellular immune responses derived mainly from Th1-related cytokines. Th2 type immune responses can inhibit efficient immune function by secretion of several cytokines such as IL-10, TGF-beta1. In this particular study, we determined the serum levels of TGF-beta1, which plays a role in immune suppression and induction of tissue fibrosis. We evaluated the role of TGF-beta1 in the pathogenesis of chronic liver disease and cirrhosis. Fourteen chronic hepatitis B (CHB), 12 chronic hepatitis C (CHC) patients and 21 cirrhotic patients were enrolled in the study. The control group consisted of ten healthy people. Serum TGF-beta1 levels were higher in both cirrhosis and CHC group when compared to those in CHB and control groups (P < 0.05). Although serum TGF-beta1 levels in the cirrhosis group were higher than that in the CHC group, the difference was not statistically significant. In conclusion, elevated TGF-beta1 levels in patients with CHC and cirrhosis may have a role in the pathogenesis and chronicity of these diseases.

Alignment of pedicle screws with pilot holes: can tapping improve screw trajectory in thoracic spines?

Abstract: Pedicle screws are placed using pilot holes. The trajectory of pilot holes can be verified by pedicle sounding or radiographs. However, a pilot hole alone does not insure that the screw will follow the pilot hole. No studies have characterized the risk of misalignment of a pedicle screw with respect to its pilot hole trajectory. The objective of this study was to measure the misalignment angles between pedicle screws and pilot holes with or without tapping. Six human cadaveric thoracic spines were used. One hundred and forty pilot holes were created with a straight probe. Steel wires were temporarily inserted and their positions were recorded with CT scans. The left pedicles were tapped with 4.5 mm fluted tap and the right pedicles remained untapped. Pedicle screws (5.5 mm) were inserted into the tapped and untapped pedicles followed by CT scans. The trajectories of pilot holes and screws were calculated using three-dimensional vector analysis. A total of 133 pilot holes (95%) were inside pedicles. For the untapped side, 14 out of 68 (20%) screws did not follow the pilot holes and were outside the pedicles. For the tapped side, 2 out of 65 (3%) did not follow and breached the pedicles. The average misalignment angles between the screw and pilot hole trajectory were 7.7° ± 6.5° and 5.6° ± 3.2° for the untapped side and tapped side, respectively (P < 0.05). Most pedicle screws had lateral screw breach (13 out of 16) whereas most pilot holes had medial pedicle breach (6 out of 7). Tapping of pilot holes (1 mm undertap) helps align pedicle screws and reduces the risk of screw malposition. Although most pedicle screws had lateral breach, the risk of medial pedicle breach of the pilot holes must be recognized.

Regulatory-T, T-helper 1, and T-helper 2 cell differentiation in nasal mucosa of allergic rhinitis with olive pollen sensitivity.

Abstract: Background: Allergic rhinitis (AR) is a disease in which T-helper (Th)2 response is predominant and its pathogenic mechanism is still poorly understood. Aim: To e

Using the Satisfaction with Life Scale in People with Parkinson’s Disease: A Validation Study in Different European Countries

Abstract: Background. Overall, people with chronic illnesses have lower life satisfaction compared to nonclinical populations. The objective of this international study was to examine the psychometric properties of the Satisfaction with Life Scale (SWLS) in patients with Parkinson’s disease (PD). Methods. PD patients () were recruited and interviewed at different specialized services in the United Kingdom, Spain, Czech Republic, Italy, and The Netherlands. A questionnaire set including a measure of life satisfaction, quality of life (QoL), self-reported health and disability status, and sociodemographic information was used. Acceptability, reliability, and validity were examined. Results. The internal consistency was good (α = 0.81). The scale structure was satisfactory (comparative fit index = 0.99; root mean square error of approximation = 0.08). The SWLS was able to discriminate between healthy and unhealthy, disabled and nondisabled, and those perceiving a more severe impact of the disability on their lives. Concurrent validity using multiple linear regression models confirmed associations between SWLS and QoL and age. Conclusions. This study is the first to report on the use of the SWLS in PD patients in different European countries. It is a useful tool in assessing satisfaction with life in PD patients through the continuum of care.