Institution
Center for Advanced Biotechnology and Medicine
About: Center for Advanced Biotechnology and Medicine is a based out in . It is known for research contribution in the topics: Reverse transcriptase & Protein structure. The organization has 836 authors who have published 1171 publications receiving 95360 citations.
Papers published on a yearly basis
Papers
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TL;DR: Detailed analyses of a relatively small number of representative proteins provide a foundation for understanding this large family of signaling proteins, which consists of two conserved components, a histidine protein kinase and a response regulator protein.
Abstract: ▪ Abstract Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase and a response regul...
3,406 citations
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TL;DR: Limiting autophagy under conditions of nutrient limitation can restore cell death to apoptosis-refractory tumors, but this necrosis is associated with inflammation and accelerated tumor growth.
1,888 citations
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TL;DR: Defective autophagy is a mechanism for p62 upregulation commonly observed in human tumors that contributes directly to tumorigenesis likely by perturbing the signal transduction adaptor function of p62-controlling pathways critical for oncogenesis.
1,466 citations
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TL;DR: The identification of genes that control cell death and the appreciation of the role of apoptosis in development and disease has been identified and the characterization of the function of these gene products will help to define the process of cell death at the biochemical level.
Abstract: Apoptosis or programmed cell death is a genetically controlled response for cells to commit suicide. The symptoms of apoptosis are viability loss accompanied by cytoplasmic boiling, chromatin condensation, and DNA fragmentation (Wyllie 1980). Pathologists and developmental biologists have cataloged the occurrences of apoptosis for many years based on these defined morphological features, but what has propelled apoptosis into the forefront of basic research has been the identification of genes that control cell death and the appreciation of the role of apoptosis in development and disease. Regulation of cell death is essential for normal development and is an important defense against viral infection and the emergence of cancer. Too much cell death can lead to impaired development and degenerative diseases, whereas too little cell death car/lead to cancer and persistent and sustained viral infection. The process of apoptosis is controlled through the expression of an increasing number of genes conserved in nematodes through mammals and viruses. Some gene products are activators of apoptosis, whereas others are inhibitors and the characterization of the function of these gene products will help to define the process of cell death at the biochemical level.
1,366 citations
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TL;DR: Structures were obtained for three intermediates in the hydroxylation reaction of camphor by P450cam with trapping techniques and cryocrystallography and reveal a network of bound water molecules that may provide the protons needed for the reaction.
Abstract: Members of the cytochrome P450 superfamily catalyze the addition of molecular oxygen to nonactivated hydrocarbons at physiological temperature-a reaction that requires high temperature to proceed in the absence of a catalyst. Structures were obtained for three intermediates in the hydroxylation reaction of camphor by P450cam with trapping techniques and cryocrystallography. The structure of the ferrous dioxygen adduct of P450cam was determined with 0.91 angstrom wavelength x-rays; irradiation with 1.5 angstrom x-rays results in breakdown of the dioxygen molecule to an intermediate that would be consistent with an oxyferryl species. The structures show conformational changes in several important residues and reveal a network of bound water molecules that may provide the protons needed for the reaction.
1,211 citations
Authors
Showing all 836 results
Name | H-index | Papers | Citations |
---|---|---|---|
Martin J. Blaser | 147 | 820 | 104104 |
Masayori Inouye | 111 | 652 | 43410 |
Constance L. Cepko | 100 | 275 | 35476 |
Eileen White | 95 | 226 | 44992 |
Ronald G. Tompkins | 93 | 526 | 41859 |
Martin L. Yarmush | 91 | 702 | 34591 |
Liang Tong | 81 | 342 | 21752 |
John L. Markley | 76 | 595 | 28513 |
Gaetano T. Montelione | 76 | 437 | 19992 |
Robert M. Krug | 76 | 161 | 17311 |
Roger L. Williams | 75 | 188 | 22360 |
Richard H. Ebright | 72 | 231 | 16760 |
Michael M. Shen | 71 | 152 | 17732 |
Fei Xu | 71 | 743 | 24009 |
Victor E. Marquez | 69 | 419 | 16509 |