Institution
Center for Biologics Evaluation and Research
Facility•Silver Spring, Maryland, United States•
About: Center for Biologics Evaluation and Research is a facility organization based out in Silver Spring, Maryland, United States. It is known for research contribution in the topics: Virus & Vaccination. The organization has 3024 authors who have published 4648 publications receiving 228078 citations. The organization is also known as: CBER.
Topics: Virus, Vaccination, Immune system, Antibody, Population
Papers published on a yearly basis
Papers
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TL;DR: A bioinformatics tool was developed and used to identify proteomic patterns in serum that distinguish neoplastic from non-neoplastic disease within the ovary, justifying a prospective population-based assessment of proteomic pattern technology as a screening tool for all stages of ovarian cancer in high-risk and general populations.
3,144 citations
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TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Abstract: We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentatively designated as IL-29, IL-28A and IL-28B, respectively, by HUGO). The expression of IFN-lambda mRNAs was inducible by viral infection in several cell lines. We identified a distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2). Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway. This receptor-ligand system may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
1,725 citations
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TL;DR: The quality of a CD4+ T-cell cytokine response can be a crucial determinant in whether a vaccine is protective, and may provide a new and useful prospective immune correlate of protection for vaccines based on T-helper type 1 (TH1) cells.
Abstract: CD4+ T cells have a crucial role in mediating protection against a variety of pathogens through production of specific cytokines. However, substantial heterogeneity in CD4+ T-cell cytokine responses has limited the ability to define an immune correlate of protection after vaccination. Here, using multiparameter flow cytometry to assess the immune responses after immunization, we show that the degree of protection against Leishmania major infection in mice is predicted by the frequency of CD4+ T cells simultaneously producing interferon-gamma, interleukin-2 and tumor necrosis factor. Notably, multifunctional effector cells generated by all vaccines tested are unique in their capacity to produce high amounts of interferon-gamma. These data show that the quality of a CD4+ T-cell cytokine response can be a crucial determinant in whether a vaccine is protective, and may provide a new and useful prospective immune correlate of protection for vaccines based on T-helper type 1 (TH1) cells.
1,308 citations
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TL;DR: Differences in humans and mice lacking gamma c expression indicate species-specific differences in the roles of gamma c-dependent cytokines or in the existence of redundant pathways.
1,030 citations
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TL;DR: Results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function, and the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
Abstract: It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
995 citations
Authors
Showing all 3036 results
Name | H-index | Papers | Citations |
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Elaine S. Jaffe | 156 | 828 | 112412 |
Charles M. Rice | 154 | 561 | 83812 |
Lance A. Liotta | 153 | 832 | 102335 |
Patrick C. Walsh | 136 | 776 | 77683 |
Alan Sher | 132 | 486 | 68128 |
Richard A. Koup | 122 | 401 | 61738 |
Milton C. Weinstein | 121 | 482 | 85070 |
Jack E. Dixon | 115 | 408 | 47201 |
Daniel C. Douek | 113 | 376 | 44694 |
Alan W. Partin | 111 | 710 | 54213 |
Mark Raffeld | 101 | 418 | 39194 |
Neil E. Caporaso | 100 | 497 | 35734 |
Emanuel F. Petricoin | 93 | 488 | 36145 |
Alexander D. MacKerell | 92 | 474 | 67029 |
Gerald B. Pier | 88 | 395 | 26166 |