Institution
Centers for Disease Control and Prevention
Government•Atlanta, Georgia, United States•
About: Centers for Disease Control and Prevention is a government organization based out in Atlanta, Georgia, United States. It is known for research contribution in the topics: Population & Public health. The organization has 58238 authors who have published 82592 publications receiving 4405701 citations. The organization is also known as: CDC & Centers for Disease Control and Prevention (CDC).
Topics: Population, Public health, Poison control, Vaccination, Acquired immunodeficiency syndrome (AIDS)
Papers published on a yearly basis
Papers
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University of Miami1, Jackson Memorial Hospital2, University of Paris-Sud3, United States Department of Veterans Affairs4, Case Western Reserve University5, Israel Ministry of Health6, National and Kapodistrian University of Athens7, National University of Ireland, Galway8, University of Verona9, University of Barcelona10, Rush University Medical Center11, University of Madras12, Public Health England13, University of East Anglia14, Centers for Disease Control and Prevention15, Royal Brisbane and Women's Hospital16, University of Calgary17, Peking University18, AstraZeneca19
TL;DR: The epidemiology of Klebsiella pneumoniae carbapenemases across continents is summarized, issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control are discussed.
Abstract: Klebsiella pneumoniae carbapenemases (KPCs) were originally identified in the USA in 1996. Since then, these versatile β-lactamases have spread internationally among Gram-negative bacteria, especially K pneumoniae, although their precise epidemiology is diverse across countries and regions. The mortality described among patients infected with organisms positive for KPC is high, perhaps as a result of the limited antibiotic options remaining (often colistin, tigecycline, or aminoglycosides). Triple drug combinations using colistin, tigecycline, and imipenem have recently been associated with improved survival among patients with bacteraemia. In this Review, we summarise the epidemiology of KPCs across continents, and discuss issues around detection, present antibiotic options and those in development, treatment outcome and mortality, and infection control. In view of the limitations of present treatments and the paucity of new drugs in the pipeline, infection control must be our primary defence for now.
1,314 citations
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TL;DR: The Working Group on Civilian Biodefense has developed consensus-based recommendations for measures to be taken by medical and public health professionals if tularemia is used as a biological weapon against a civilian population.
Abstract: ObjectiveThe Working Group on Civilian Biodefense has developed consensus-based
recommendations for measures to be taken by medical and public health professionals
if tularemia is used as a biological weapon against a civilian population.ParticipantsThe working group included 25 representatives from academic medical
centers, civilian and military governmental agencies, and other public health
and emergency management institutions and agencies.EvidenceMEDLINE databases were searched from January 1966 to October 2000, using
the Medical Subject Headings Francisella tularensis, Pasteurella tularensis, biological weapon, biological terrorism, bioterrorism, biological warfare, and biowarfare. Review of these references led to identification
of relevant materials published prior to 1966. In addition, participants identified
other references and sources.Consensus ProcessThree formal drafts of the statement that synthesized information obtained
in the formal evidence-gathering process were reviewed by members of the working
group. Consensus was achieved on the final draft.ConclusionsA weapon using airborne tularemia would likely result 3 to 5 days later
in an outbreak of acute, undifferentiated febrile illness with incipient pneumonia,
pleuritis, and hilar lymphadenopathy. Specific epidemiological, clinical,
and microbiological findings should lead to early suspicion of intentional
tularemia in an alert health system; laboratory confirmation of agent could
be delayed. Without treatment, the clinical course could progress to respiratory
failure, shock, and death. Prompt treatment with streptomycin, gentamicin,
doxycycline, or ciprofloxacin is recommended. Prophylactic use of doxycycline
or ciprofloxacin may be useful in the early postexposure period.
1,297 citations
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TL;DR: An avian H5N1 influenza A virus was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza, causing 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens.
Abstract: An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.
1,291 citations
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TL;DR: Researchers should familiarize themselves with the threats to validity inherent in this type of assessment and design research that minimizes these threats as much as possible.
1,288 citations
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TL;DR: The transfected human dermal microvascular endothelial cells (HMEC) with a PBR-322-based plasmid containing the coding region for the simian virus 40 A gene product, large T antigen, and succeeded in immortalizing them, making HMEC-1 the first immortalized human microv vascular endothelial cell line that retains the morphologic, phenotypic, and functional characteristics of normal human microfiltration cells.
1,285 citations
Authors
Showing all 58382 results
Name | H-index | Papers | Citations |
---|---|---|---|
Graham A. Colditz | 261 | 1542 | 256034 |
David J. Hunter | 213 | 1836 | 207050 |
Bernard Rosner | 190 | 1162 | 147661 |
Richard Peto | 183 | 683 | 231434 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Didier Raoult | 173 | 3267 | 153016 |
James F. Sallis | 169 | 825 | 144836 |
David R. Jacobs | 165 | 1262 | 113892 |
Steven N. Blair | 165 | 879 | 132929 |
Gordon J. Freeman | 164 | 579 | 105193 |
Dennis R. Burton | 164 | 683 | 90959 |
Rory Collins | 162 | 489 | 193407 |
Ali H. Mokdad | 156 | 634 | 160599 |
Caroline S. Fox | 155 | 599 | 138951 |
Paul Elliott | 153 | 773 | 103839 |