Showing papers by "Central Drug Research Institute published in 1975"
TL;DR: Himachalol has been identified as the major antispasmodic constituent in the wood of Cedrus deodara and was devoid of spasmolytic effect on the bronchial musculature of guinea pig but was 3.3 times more potent than papaverine in antagonizing epinephrine-induced contraction of the Guinea pig seminal vesicle.
46 citations
TL;DR: A series of isatin-3-anils (with or without a N-piperidino/morpholinomethyl substituent) have been screened for their cysticidal activity against Schizopyrenus russelli.
Abstract: A series of isatin-3-anils (with or without a N-piperidino/morpholinomethyl substituent) have been screened for their cysticidal activity against Schizopyrenus russelli. Their ability to cause excystment has also been studied.
30 citations
TL;DR: In this paper, six biscoclaurine alkaloids have been isolated from Cocculus pendulus (Forsk) Diels and assigned structures and stereochemistry by a series of chemical transformations and spectral studies.
23 citations
TL;DR: In this paper, it was shown that Papaver somniferum papaverine arises from (−)-norreticuline via norlaudanidine and norlanaudanosine.
22 citations
TL;DR: The structure of hedychenone, a furanoid diterpene, isolated from the rhizomes of Hedychium spicatum has been deduced on the basis of spectroscopic and chemical evidence as mentioned in this paper.
21 citations
TL;DR: It appears that effects of clonidine on the vasomotor loci of the medulla oblongata and the spinal cord contribute to its hypotensive action.
Abstract: 1 The effect of clonidine on the direct excitability of hypothalamic, medullary and spinal vasomotor loci has been investigated in cats anaesthetized with chloralose 2 Clonidine inhibited the excitability of these loci when it was localized to the central sites by intracerebroventricular, intravertebral arterial or intrathecal injection in very low doses (1-2 mug) 3 Topical application of clonidine (001 percent and 10 percent) to the floor of the fourth ventricle inhibited pressor responses evoked either by stimulation of medullary or hypothalamic vasomotor areas Inhibition of the pressor responses was accompanied by hypotension and bradycardia in many experiments 4 It appears that effects of clonidine on the vasomotor loci of the medulla oblongata and the spinal cord contribute to its hypotensive action
17 citations
TL;DR: In this paper, various chemical and spectroscopic methods have been employed to elucidate the structure of centdarol as 2β,7β-dihydroxyhimachal-3-ene.
15 citations
12 citations
TL;DR: During encystation of Hartmannella culbertsoni induced by taurine or epinephrine, 60-70% of the reserve glycogen is degraded and the carbon skeleton of glycogen but not that of protein is utilised in the synthesis of cyst wall cellulose.
8 citations
TL;DR: Sagittariol a new diterpene has been isolated from Sagittaria sagittifolia and characterized as labda-7,14-dien-13(S,17-diol.
7 citations
TL;DR: Mallotin, a new C 32 triterpene from Mallotous stenanthus, has been isolated and its structure established as 24,24-dimethyl-lanosta-7,25-dien-3α-ol.
TL;DR: Rats inserted in 1 horn of rats and their uterin were subsequently studied to determined the effect of these IUDs on in vitro estradiol-17beta, 6,7-Tritiated and progesterone 1,2-tritiated.
TL;DR: It is suggested that the antifertility effect of Centchroman may be due principally to the ability of the compound to elicit estrogen-like responses in the Fallopian tube and uterus.
TL;DR: The inference is that the increase of tyrosine aminotransferase activity in vivo by tetracycline is brought about by the latter inhibiting the lysosomal catheptic action.
Abstract: Rat liver tyrosine aminotransferase was purified 200-fold and an antiserum raised against it in rabbits. 2. Hepatic tyrosine aminotransferase activity was increased fourfold by tyrosine, twofold by tetracycline, 2.5-fold by cortisone 21-acetate and ninefold by a combination of tyrosine and cortisol administered intraperitoneally to rats. 3. Radioimmunoassay with 14C-labelled tyrosine aminotransferase, in conjunction with rabbit antiserum against the enzyme, revealed that cortisol stimulates the synthesis of the enzyme de novo, but that tetracycline has no such effect. 4. Incubation of rat liver homogenates with purified tyrosine aminotransferase in vitro leads to a rapid inactivation of the enzyme, which tetracycline partially inhibits. 5. The inactivation is brought about by intact lysosomes, and the addition of 10mM-cysteine increases the rate of enzyme inactivation, which is further markedly increased by 10mM-Mg2+ and 10mM-ATP. Here again tetracycline partially inhibits the decay rate, leading to the inference that the increase of tyrosine aminotransferase activity in vivo by tetracycline is brought about by the latter inhibiting the lysosomal catheptic action.
TL;DR: Activation of adenyl cyclase and phosphorylation of cellular proteins appears to precede RNA and protein synthesis in the imbibed seeds.
TL;DR: The antifertility effect of DBF may be due to its ability to elicit many biochemical effects similar to those induced by a typical estrogen.
01 Jan 1975
TL;DR: It is not appreciated that soil is an ideal habitat for small free-living aerobic amoebae to exist in large numbers in active (trophic) form from soil, and from soil these amoEBae spread to other sites.
Abstract: It has been generally postulated that primary amoebic meningoencephalitis in man caused by the free-living amoeba, Naegleria aerobia (see chapters 3 and 4), is due to the entry of trophozoites through the intranasal route during swimming or bathing in fresh water. Therefore, it is not appreciated that soil is an ideal habitat for small free-living aerobic amoebae to exist in large numbers in active (trophic) form. From soil these amoebae spread to other sites.
TL;DR: In the main, the genetic phenomenon identified in V. cholerae resembled sexual mating in Escherichia coli, chromosomal transfer occurring from a donor to a receipient strain by conjugation.
Abstract: The demonstration of genetic recombination in Vibrio cholerae by Bhaskaran [1–4], provided new avenues for the study of variability in Vibrio species by Bhaskaran, Sinha and Iyer [8], Bhaskaran and Sinha [5], development of vaccine strains and evaluation of immune mechanisms in cholera by Bhaskaran and Sinha [6], Sinha and Bhaskaran [11, 12]. In the main, the genetic phenomenon identified in V. cholerae resembled sexual mating in Escherichia coli, chromosomal transfer occurring from a donor to a receipient strain by conjugation. The donor trait was determined by transmissible sex factor, designated P: P+ denoting the presence and P− absence of the factor in the strain concerned.
01 Jan 1975
TL;DR: An outline of the system of classification of Amoebida based on sound characters and probable phylogenetic relationships is presented here.
Abstract: In the revised classification of the phylum Protozoa by Honigberg et al. (1964), the class Rhizopodea by von Siebold (1845) has been divided into subclasses Lobosia Carpenter (1861), and Filosia Leidy (1879). The order Amoebida Kent (1880), has been included in the subclass Lobosia for naked, typically uninucleate amoebae, the majority of which are free-living, the rest parasitic. An outline of the system of classification of Amoebida based on sound characters and probable phylogenetic relationships is presented here.
TL;DR: As a result of the treatment with NE, the Fallopian tube and uterus recorded a significant increase in the concentrations of protein and glycogen; however, the NPN level of the tube was diminished and that of the uterus was enhanced.
TL;DR: The results suggest that estradiol dipropionate, when given at a dose of 1 mg per animal intramuscularly daily for 5 days commencing from day 2 of instillation, antagonises the action of quinacrine in producing tubal occlusion.
01 Jan 1975
TL;DR: Extensive studies carried out at Rothamsted Experimental Station, England between 1941 and 1952 led to the use of non-nutrient agar and a suitable edible bacterium, such as Aerobacter sp.
Abstract: Extensive studies carried out at Rothamsted Experimental Station, England between 1941 and 1952 (summarised in chapters 1, 2 and 3) led to the use of non-nutrient agar and a suitable edible bacterium, such as Aerobacter sp., for the isolation and culture of small free-living amoebae, other holozoic protozoa and amoeboid organisms from soil and other substrates, and for the count of their numbers in these substrates. A rational system of classification of small free-living amoebae, based on their nuclear structure, nuclear division and other characters and possible phylogenetic relationship, was also developed. It was inconceivable in those days even to imagine that soil amoebae might cause disease in man.
01 Aug 1975
TL;DR: Mitochondrial fractions prepored from tissues of weanling rats receiving the magnesium-low diet for 60 days showed increased swelling as evidenced by their differential response to calcium pentachlorophenol, phloridzin, orp-chloromercuri benzoate as compared to mitochondria prepared from tissue of control animals.
Abstract: 1. Hypomagnesemia was induced in weanling rats by feeding a magnesium-low diet. During a 78 day regimen on this diet, the animals showed retarded growth rate and low concentrations of magnesium in liver, kidney, skeletal muscle and heart but not in brain. When animals fed with the magnesium-low diet were returned to the control diet for 18 days, the Mg content of serum, heart, liver and kidney increased appreciably. The Mg content of skeletal muscle did not increase on supplementation. 2. Marked inhibition of P:O ratios was noticed in mitochondria prepared from magnesium deficient rats. P:O ratios were resorted to normal by supplementation with Mg. 3. Hypomagnesemia produced as above also led to depletion of tissue proteins and mitochondrial proteins. On injecting valine-1-14C such animals incorporatedin vivo significantly less of radioactivity into tissue and mitochondrial proteins. This defect was also partially corrected on returning the animals to the control diet. 4. Mitochondrial fractions prepored from tissues of weanling rats receiving the magnesium-low diet for 60 days showed increased swelling as evidenced by their differential response to calcium pentachlorophenol, phloridzin, orp-chloromercuri benzoate as compared to mitochondria prepared from tissues of control animals.