Institution
Central Drug Research Institute
Facility•Lucknow, Uttar Pradesh, India•
About: Central Drug Research Institute is a facility organization based out in Lucknow, Uttar Pradesh, India. It is known for research contribution in the topics: Catalysis & Leishmania donovani. The organization has 4357 authors who have published 7257 publications receiving 143871 citations. The organization is also known as: Central Drug Research Institute, Lucknow & CDRI.
Topics: Catalysis, Leishmania donovani, Ring (chemistry), Aryl, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: The crude extract of the stembark of Streblus asper, a traditionally used medicinal plant of India, revealed significant macrofilaricidal activity against Litomosoides carinii and Brugia malayi in rodents, opening up the possibility of generating new leads in the development of novel macrofilericides.
Abstract: The crude extract of the stembark of Streblus asper, a traditionally used medicinal plant of India, revealed significant macrofilaricidal activity against Litomosoides carinii and Brugia malayi in rodents. The study revealed two cardiac glycosides, K029 (asperoside) and K030 (strebloside) of the extract to be responsible for antifilarial activity. Of the two glycosides, the more effective macrofilaricide was K029 which was active at 50 mg/kg orally against L. carinii (>90%), B. malayi (>70%), and Acanthocheilonema viteae (>70%) in their respective hosts. The glycosides were also active in vitro against all the three filarial species. Significantly weak activity was detected in glycon and aglycon portions of the parent glycosides (K029 and K030). Several cardiac glycosides of other origins did not show any comparable antifilarial efficacy. The aglycosidic portion of the extract, however, showed poor adulticidal activity (44.5% activity at 1 g/kg against L. carinii). The present finding, thus, opens up the possibility of generating new leads in the development of novel macrofilaricides. © 1992 Wiley-Liss, Inc.
60 citations
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TL;DR: Anti-inflammatory activity of 3 is comparable while analgesic activity was found to be better than that of standard drug.
60 citations
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TL;DR: It is suggested that bilirubin, through the development of oxidative stress, induces P. falciparum cell death and that the malaria parasite lacks an HO system probably to protect itself from bilirUBin-induced cell death as a second line of defense.
60 citations
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TL;DR: The oxidative stress was highest in liver followed by brain and kidney after oral CuSO4 exposure in a rat model, and levels correlated with the respective organ dysfunction and tissue free Cu concentration.
60 citations
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TL;DR: The study shows the similar trend in lipid profile and other parameters studied in both patients with OA and patients with RA with more pronounced changes in RA.
Abstract: Progression of Rheumatoid arthritis (RA) and osteoarthritis (OA) is associated with inflammation and oxidative stress. Previous studies have shown that there was no difference between RA and OA patients regarding the percentages of the different lymphocytes subsets reflecting the abnormalities in T cells and its subsets that may contribute to the pathogenesis of OA as in RA. Therefore, the present study was aimed to analyze that whether disease activity of OA is able to affect a few serological and biochemical parameters in the same way as RA does or differently. The study was done on 36 asymptomatic controls (25 women), 28 patients with OA (20 women), 36 patients with RA (22 women). Patients with OA were screened according to radiological and clinical finding of Kellgren and Lawrence grade and ACR criteria and assessed by VAS and WOMAC score. Patients with RA were selected who were fulfilling 4/5 symptoms of ACR criteria, and their DAS28-CRP, VAS score, and RF positivity were evaluated. Participants of the groups were matched for sex, age, weight, and height (body mass index). The BMI of all three groups was also found to be the same (P > 0.05). The mean level of LDL, Cholesterol, MDA, CRP, and Triglyceride was significantly (P < 0.05 or P < 0.01) higher in both OA and RA as compared to control. The mean level of total lipid, cholesterol, MDA, CRP, and triglyceride was found to be significantly (P < 0.05 or P < 0.01) higher in RA as compared to OA. The pre-treatment CRP level of both groups of patients showed significant and direct relation with total lipid (r = 0.27, P < 0.05) and cholesterol (r = 0.66, P < 0.01). Inverse relation was observed between Uric acid and Creatinine (r = −0.26, P < 0.05) and cholesterol and HDL (r = −0.34, P < 0.01). Our study shows the similar trend in lipid profile and other parameters studied in both patients with OA and patients with RA with more pronounced changes in RA.
60 citations
Authors
Showing all 4385 results
Name | H-index | Papers | Citations |
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Sanjay Kumar | 120 | 2052 | 82620 |
John A. Katzenellenbogen | 95 | 691 | 36132 |
Brajesh K. Singh | 83 | 401 | 24101 |
Gaurav Sharma | 82 | 1244 | 31482 |
Sudhir Kumar | 82 | 524 | 216349 |
Pramod K. Srivastava | 79 | 390 | 27330 |
Mohan K. Raizada | 75 | 473 | 21452 |
Syed F. Ali | 71 | 446 | 18669 |
Ravi Shankar | 66 | 672 | 19326 |
Ramesh Chandra | 66 | 620 | 16293 |
Manoj Kumar | 65 | 408 | 16838 |
Manish Kumar | 61 | 1425 | 21762 |
Anil Kumar Saxena | 58 | 310 | 10107 |
Sanjay Krishna | 56 | 624 | 13731 |
Naibedya Chattopadhyay | 56 | 242 | 9795 |