Institution
Central Drug Research Institute
Facility•Lucknow, Uttar Pradesh, India•
About: Central Drug Research Institute is a facility organization based out in Lucknow, Uttar Pradesh, India. It is known for research contribution in the topics: Catalysis & Leishmania donovani. The organization has 4357 authors who have published 7257 publications receiving 143871 citations. The organization is also known as: Central Drug Research Institute, Lucknow & CDRI.
Topics: Catalysis, Leishmania donovani, Ring (chemistry), Aryl, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: Two simple straightforward syntheses of triazolo isoquinolines and isochromenes from 2-alkynylbenzaldehydes as a common synthon are described, which involves formation of the corresponding heterocycles under metal-free conditions in good yields.
Abstract: We describe two simple straightforward syntheses of triazolo isoquinolines (3) and isochromenes (7) from 2-alkynylbenzaldehydes (1) as a common synthon The synthetic strategy for 3 involves formation of the (E)-1-(2-nitrovinyl)-2-(alkynyl)benzene species 2 via condensation of synthon 1 with nitromethane followed by a [3 + 2] cycloaddition/extrusion of the nitro group/regioselective 6-endo cyclization domino sequence In yet another strategy, the synthon 1 was condensed with nitromethane followed by electrophilic iodo cyclization of the resulting 2-nitro-1-(2-(alkynyl)phenyl)ethanol (6) to furnish iodo isochromene derivatives The salient feature of the above two strategies involves formation of the corresponding heterocycles under metal-free conditions in good yields
52 citations
TL;DR: The title compounds were evaluated for antimalarial activity against Plasmodium falciparum in vitro and showed MIC in the range of 2-50 microg/mL.
52 citations
TL;DR: In this article, a 3-component condensation of isotoic anhydride, amine, and aldehyde in presence of iodine was used to obtain a moderate to good yield.
52 citations
TL;DR: It is found that RES significantly enhances the caspase-mediated cytotoxic activity of CPA on MCF-7 cells in vitro, suggesting the possibility of a new combination chemotherapeutic regimen leading to improvements in the treatment of breast cancer.
52 citations
TL;DR: The feasibility of inhibiting erythrocyte invasion with antibodies directed against receptor-binding domains of ery Throcyte binding proteins is examined to provide support for the development of recombinant vaccines based on the homologous binding domains of P. knowlesi.
52 citations
Authors
Showing all 4385 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Sanjay Kumar | 120 | 2052 | 82620 |
| John A. Katzenellenbogen | 95 | 691 | 36132 |
| Brajesh K. Singh | 83 | 401 | 24101 |
| Gaurav Sharma | 82 | 1244 | 31482 |
| Sudhir Kumar | 82 | 524 | 216349 |
| Pramod K. Srivastava | 79 | 390 | 27330 |
| Mohan K. Raizada | 75 | 473 | 21452 |
| Syed F. Ali | 71 | 446 | 18669 |
| Ravi Shankar | 66 | 672 | 19326 |
| Ramesh Chandra | 66 | 620 | 16293 |
| Manoj Kumar | 65 | 408 | 16838 |
| Manish Kumar | 61 | 1425 | 21762 |
| Anil Kumar Saxena | 58 | 310 | 10107 |
| Sanjay Krishna | 56 | 624 | 13731 |
| Naibedya Chattopadhyay | 56 | 242 | 9795 |