Central Drug Research Institute

About: Central Drug Research Institute is a facility organization based out in Lucknow, Uttar Pradesh, India. It is known for research contribution in the topics: Leishmania donovani & Brugia malayi. The organization has 4357 authors who have published 7257 publications receiving 143871 citations. The organization is also known as: Central Drug Research Institute, Lucknow & CDRI.

Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion–induced ischaemia in rat

Abstract: The neuroprotective potential of ethanol:water (1:1) extract of rhizomes of Acorus calamus (AC-002) has been investigated in middle cerebral artery occlusion (MCAO)-induced ischaemia in rats A significant behavioural impairment in Rota-Rod performance and grid walking was observed in rats, 72 hours after MCAO as compared to sham-operated animals These rats also exhibited an increase in lipid peroxidation (cortex -157%, corpus striatum - 58%) and a decrease in glutathione levels (cortex - 59%, corpus striatum - 34%) and superoxide dismutase (SOD) activity (cortex - 64%, corpus striatum - 32%) as compared to sham-operated animals Ischaemic rats treated with AC-002 (25 mg/kg, po) exhibited a significant improvement in neurobehavioural performance viz Rota-Rod performance and grid walking as compared to the MCAO group Interestingly, treatment with AC-002 in MCAO rats significantly decreased malonaldialdehyde levels in cortex as compared to ischaemic rats A significant increase in reduced glutathione levels and SOD activity was also observed both in cortex and corpus striatum in MCAO rats treated with AC-002 in comparison to MCAO rats Treatment with AC-002 in MCAO rats also reduced the contralateral cortical infarct area (19%) as compared to MCAO rats (33%) Neurological function score was improved in the AC-002-treated rats as compared to the MCAO group The results of the present study indicate the neuroprotective efficacy of A calamus in the rat model of ischaemia

Chemistry and pharmacology of Withania coagulans: an Ayurvedic remedy.

Abstract: Objectives The use of Withania coagulans, a member of the solanaceae family, has been highlighted in Ayurveda. We have reviewed the chemical constituents and pharmacological properties of W. coagulans, as well as its morphology. This has included therapeutic effects of the whole plant and its extracts, fractions and isolated withanolides. The hepatoprotective, anti-inflammatory, antihyperglycaemic, hypolipidaemic, free radical scavenging, antimicrobial, cardiovascular, central nervous system depressant, immunomodulating, antitumour and cytotoxic activities of W. coagulans have been described. Key findings Research carried out using different biological testing in-vitro and in-vivo techniques supported the claims. Summary This review has covered the morphology, chemistry and pharmacology of the plant. It has described 37 compounds containing 46 references.