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Institution

Centre national de la recherche scientifique

GovernmentParis, France
About: Centre national de la recherche scientifique is a government organization based out in Paris, France. It is known for research contribution in the topics: Population & Catalysis. The organization has 239077 authors who have published 382421 publications receiving 13670943 citations.
Topics: Population, Catalysis, Gene, Thin film, Laser


Papers
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Journal ArticleDOI
Clotilde Théry1, Kenneth W. Witwer2, Elena Aikawa3, María José Alcaraz4  +414 moreInstitutions (209)
TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.
Abstract: The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

5,988 citations

BookDOI
01 Jan 1999
TL;DR: This chapter discusses Ant Foraging Behavior, Combinatorial Optimization, and Routing in Communications Networks, and its application to Data Analysis and Graph Partitioning.
Abstract: 1. Introduction 2. Ant Foraging Behavior, Combinatorial Optimization, and Routing in Communications Networks 3. Division of Labor and Task Allocation 4. Cemetery Organization, Brood Sorting, Data Analysis, and Graph Partitioning 5. Self-Organization and Templates: Application to Data Analysis and Graph Partitioning 6. Nest Building and Self-Assembling 7. Cooperative Transport by Insects and Robots 8. Epilogue

5,822 citations

Journal ArticleDOI
TL;DR: In this paper, the authors present the first global assessment of recent tree mortality attributed to drought and heat stress and identify key information gaps and scientific uncertainties that currently hinder our ability to predict tree mortality in response to climate change and emphasizes the need for a globally coordinated observation system.

5,811 citations

Journal ArticleDOI
TL;DR: In this article, a metallic solid with long-range orientational order, but with icosahedral point group symmetry, which is inconsistent with lattice translations, was observed and its diffraction spots are as sharp as those of crystals but cannot be indexed to any Bravais lattice.
Abstract: We have observed a metallic solid (Al-14-at.%-Mn) with long-range orientational order, but with icosahedral point group symmetry, which is inconsistent with lattice translations. Its diffraction spots are as sharp as those of crystals but cannot be indexed to any Bravais lattice. The solid is metastable and forms from the melt by a first-order transition.

5,702 citations

Journal ArticleDOI
TL;DR: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) as discussed by the authors provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk distribution.

5,668 citations


Authors

Showing all 239423 results

NameH-indexPapersCitations
Guido Kroemer2361404246571
Trevor W. Robbins2311137164437
Robert J. Lefkowitz214860147995
Pierre Chambon211884161565
Bruce M. Spiegelman179434158009
Tony Hunter175593124726
Kari Alitalo174817114231
Didier Raoult1733267153016
Marc G. Caron17367499802
Sophie Henrot-Versille171957157040
George F. Koob171935112521
Richard H. Friend1691182140032
Philippe Froguel166820118816
Marc A. Pfeffer166765133043
Anders Björklund16576984268
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023107
2022892
202111,361
202012,602
201912,217
201812,380