Centro Universitário das Faculdades Metropolitanas Unidas

About: Centro Universitário das Faculdades Metropolitanas Unidas is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Population & The Internet. The organization has 358 authors who have published 286 publications receiving 1289 citations. The organization is also known as: FMU.

An Overview of Animal Models Related to Schizophrenia.

Abstract: Schizophrenia is a heterogeneous psychiatric disorder that is poorly treated with current therapies. In this brief review, we provide an update regarding the use of animal models to study schizophrenia in an attempt to understand its aetiology and develop novel therapeutic strategies. Tremendous progress has been made developing and validating rodent models that replicate the aetiologies, brain pathologies, and behavioural abnormalities associated with schizophrenia in humans. Here, models are grouped into 3 categories-developmental, drug induced, and genetic-to reflect the heterogeneous risk factors associated with schizophrenia. Each of these models is associated with varied but overlapping pathophysiology, endophenotypes, behavioural abnormalities, and cognitive impairments. Studying schizophrenia using multiple models will permit an understanding of the core features of the disease, thereby facilitating preclinical research aimed at the development and validation of better pharmacotherapies to alter the progression of schizophrenia or alleviate its debilitating symptoms.

Tradução e validação cultural do questionário algofuncional de Lequesne para osteoartrite de joelhos e quadris para a língua portuguesa

Abstract: OBJECTIVE: translation, validation and cultural adaptation of the algofunctional index of Lequesne for the Portuguese language. PATIENTS AND METHODS: the original questionnaire, published in English, was translated by three English professors, and after back translated by others three professors. Four physiotherapists had congregated and comparing the translations, they had elaborated the first version. This was applied to 11 patients with diagnosis of osteoarthritis (OA) of knees and/or hips, and this version was recognized fully by the patients, who had not reported understanding problems. This version, considered as definitive, was them applied to others 73 patients in the following form: a time for observer 1 (A1), in the same day for observer 2 (A2) and one week later for observer 1 or 2 (A3). Jointly it was collected data on age, sex and applied questionnaire Westerm Ontario and McMaster Universities WOMAC in its version validated for Portuguese language. RESULTS: for osteoarthritis of knees, the patients of the pre-test (10 of 11 evaluated) had average age of 63 years (DP=9.3) and 2 were men. Its average grade for the index of Lequesne was of 14.9 (DP=5.1). The patients, evaluated with the definitive version, in number of 42, had in average 67.5 years (DP=8.7), 5 were men. Its average for the index of Lequesne was for A1=11.9 (DP=5.0), for A2=12.1 (DP=6.4) and A3=11.3 (DP=7.9). The intraclass correlation between A1 and A2 was of 0.99 and between A1 and A3 was of 0,99. The Pearson coefficient between A1 and WOMAC pain was of 0.800, WOMAC stiffness was of 0.640 and WOMAC function was 0.828, all with statistical significance. For osteoarthritis of hips, the patients of the pre-test (3 of the 11 evaluated) had average age of 67 years (DP=9.18) and were all women. Its average grade for the index of Lequesne was of 11.2 (DP=5.86). The patients, evaluated with the definitive version, in number of 37, had in average 66.9 years (DP=9.01), 8 were men. Its average for the index of Lequesne was for A1=12.5 (DP=5.6) for A2=12,5 (DP=5.7) and A3=14.1 (DP=6.3). The intraclass correlation between A1 and A2 was of 0.99 and between A1 and A3 was of 0.98. The coefficient of Pearson between A1 and WOMAC pain was of 0.759, WOMAC rigidity was of 0.659 and WOMAC function was 0.851, all also with statistical significance. CONCLUSION: the version for the Portuguese language (Brazil) of the algofunctional index of Lequesne, for evaluation of osteoarthritis of knees and hips is validated for use in Brazilian population.

Development and sensory profile of a probiotic beverage from apple fermented with Lactobacillus casei

Abstract: The objective of this study was the development and optimization of a probiotic apple beverage as well as the establishment of a sensory profile by using chemical, microbiological, and quantitative descriptive analysis (sensory profiling). For this purpose, both Lactobacillus casei and L. acidophilus were tested in two different media - Fuji and Gala apple juices - at different pH values. The optimal conditions to develop the apple probiotic beverage were obtained by response surface methodology. They were found to be 10 h of fermentation at 37oC in Gala apple juice. Sensorially, the clarified Gala apple juice was characterized by a caramel color, apple aroma, and an acidic apple taste. The fresh fermented probiotic apple beverage was characterized by a thick texture and sweet taste. The probiotic apple beverage stored for 28 days at 7oC presented a thick texture and acidic taste. Finally, when the fermented probiotic beverage was tested by potential consumers, it presented an acceptance index of 96%.

Glucose oxidase: A potential option to decrease the oxidative stress in stirred probiotic yogurt

Abstract: The effect of the addition of glucose oxidase as a technological option todecrease the oxidative stress in a stirred yogurt during 15 days of refrigerated storage was investigated. A significant increase in the viable population of Bifidobacteria longum (6.9–8.7 log CFU g −1 ) was observed in all yogurts added with glucose oxidase and glucose. Additionally, the yogurts containing glucose oxidase and glucose presented and caused higher pH, proteolysis rate, and contents of organic acids and aroma compounds, and this effect was comparable to the control sample (without glucose oxidase and glucose). Overall, the combined effect of the glucose oxidase system was important to reduce the oxygen content during storage of the probiotic yogurt. These findings suggest that glucose oxidase is a potential option to decrease the oxidative stress in probiotic yogurts.