Institution
CEU San Pablo University
Education•Madrid, Spain•
About: CEU San Pablo University is a education organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Adipose tissue. The organization has 1928 authors who have published 3195 publications receiving 57367 citations.
Topics: Population, Adipose tissue, Lithium, Pleiotrophin, Insulin
Papers published on a yearly basis
Papers
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National Institutes of Health1, Society for Immunotherapy of Cancer2, French Institute of Health and Medical Research3, University of Paris4, University of Bern5, Providence Portland Medical Center6, University of Mainz7, Cornell University8, University of Erlangen-Nuremberg9, Medical University of Graz10, Karolinska Institutet11, Harvard University12, CEU San Pablo University13, Memorial Sloan Kettering Cancer Center14, Lund University15, University of Southampton16, Innsbruck Medical University17, University Health Network18, Princess Margaret Cancer Centre19, Keio University20, Yamaguchi University21, Kindai University22, Cancer Research Institute23, University of Tübingen24, Loyola University Chicago25, University of Manchester26, Université de Montréal27, Georgia Regents University28, Royal Melbourne Hospital29, University of Melbourne30, Sapporo Medical University31, Kurume University32, Umeå University33, Radboud University Nijmegen34, Xi'an Jiaotong University35, Dorset County Hospital NHS Foundation Trust36, University of Texas MD Anderson Cancer Center37, Mayo Clinic38, University of Chicago39, Oregon Health & Science University40
TL;DR: Evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy, into traditional classification of cancer, designated TNM-I (TNM-Immune), and introduction of this parameter as a biomarker to classify cancers will facilitate clinical decision-making.
Abstract: Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM classification) summarizes data on tumor burden (T), presence of cancer cells in draining and regional lymph nodes (N) and evidence for metastases (M). However, it is now recognized that clinical outcome can significantly vary among patients within the same stage. The current classification provides limited prognostic information, and does not predict response to therapy. Recent literature has alluded to the importance of the host immune system in controlling tumor progression. Thus, evidence supports the notion to include immunological biomarkers, implemented as a tool for the prediction of prognosis and response to therapy. Accumulating data, collected from large cohorts of human cancers, has demonstrated the impact of immune-classification, which has a prognostic value that may add to the significance of the AJCC/UICC TNM-classification. It is therefore imperative to begin to incorporate the 'Immunoscore' into traditional classification, thus providing an essential prognostic and potentially predictive tool. Introduction of this parameter as a biomarker to classify cancers, as part of routine diagnostic and prognostic assessment of tumors, will facilitate clinical decision-making including rational stratification of patient treatment. Equally, the inherent complexity of quantitative immunohistochemistry, in conjunction with protocol variation across laboratories, analysis of different immune cell types, inconsistent region selection criteria, and variable ways to quantify immune infiltration, all underline the urgent requirement to reach assay harmonization. In an effort to promote the Immunoscore in routine clinical settings, an international task force was initiated. This review represents a follow-up of the announcement of this initiative, and of the J Transl Med. editorial from January 2012. Immunophenotyping of tumors may provide crucial novel prognostic information. The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune).
705 citations
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TL;DR: The evidence for and against the spreading LP model are discussed, as well as evidence that cell-autonomous factors govern both α-syn pathology and neuronal death.
Abstract: Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and neuronal death are commonly found in the brains of patients with clinical Parkinson disease (cPD). It is widely believed that LP appears early in the disease and spreads in synaptically coupled brain networks, driving neuronal dysfunction and death. However, post-mortem analysis of human brains and connectome-mapping studies show that the pattern of LP in cPD is not consistent with this simple model, arguing that, if LP propagates in cPD, it must be gated by cell- or region-autonomous mechanisms. Moreover, the correlation between LP and neuronal death is weak. In this Review, we briefly discuss the evidence for and against the spreading LP model, as well as evidence that cell-autonomous factors govern both α-syn pathology and neuronal death.
669 citations
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TL;DR: A mini review of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the Neurodegenerative process are given.
Abstract: Parkinson disease (PD) is a chronic, progressive neurological disease that is associated with a loss of dopaminergic neurons in the substantia nigra pars compacta of the brain. The molecular mechanisms underlying the loss of these neurons still remain elusive. Oxidative stress is thought to play an important role in dopaminergic neurotoxicity. Complex I deficiencies of the respiratory chain account for the majority of unfavorable neuronal degeneration in PD. Environmental factors, such as neurotoxins, pesticides, insecticides, dopamine (DA) itself, and genetic mutations in PD-associated proteins contribute to mitochondrial dysfunction which precedes reactive oxygen species formation. In this mini review, we give an update of the classical pathways involving these mechanisms of neurodegeneration, the biochemical and molecular events that mediate or regulate DA neuronal vulnerability, and the role of PD-related gene products in modulating cellular responses to oxidative stress in the course of the neurodegenerative process.
599 citations
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TL;DR: The data indicated that culture of both bacteria accumulate bioactive C 19 -gibberellins in relative high amounts and that these GAs appear to be physiologically active in the host plant.
Abstract: The plant-growth-promoting rhizobacteria (PGPR), Bacillus pumilus and Bacillus licheniformis, isolated from the rhizosphere of alder (Alnus glutinosa [L.] Gaertn.) have a strong growth-promoting activity. Bioassay data showed that the dwarf phenotype induced in alder seedlings by paclobutrazol (an inhibitor of gibberellin [GA] biosynthesis) was effectively reversed by applications of extracts from media incubated with both bacteria and also by exogenous GA 3 , Full-scan gas chromatography-mass spectrometry analyses on extracts of these media showed the presence of GA 1 , GA 3 , GA 4 and GA 20 , in addition to the isomers 3-epi-GA 1 and iso-GA 3 . Isotope dilution analysis indicated that epi-GA 1 was an artefact. Likewise, iso-GA 3 is also probably an artifact spontaneously formed during extraction and/or analysis. In both culture media, GA 1 was present in higher concentrations (130-150 ng ml -1 ) than GA 3 (50-60 ng ml -1 ), GA 4 (8-12 ng ml -1 ) and GAS (2-3 ng ml -1 ). The data indicated that culture of both bacteria accumulate bioactive C 19 -gibberellins in relative high amounts and that these GAs appear to be physiologically active in the host plant. The evidence suggests that the promotion of stem elongation induced by the PGPR could be mediated by bacterial GAs.
598 citations
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CEU San Pablo University1, National and Kapodistrian University of Athens2, University of Marburg3, Rush University Medical Center4, University of Toronto5, Toronto Western Hospital6, University of Pennsylvania7, Newcastle University8, University of Sydney9, University of New South Wales10, Centre national de la recherche scientifique11, Peking Union Medical College12, Columbia University13, University of Paris14, Aarhus University15, UCL Institute of Neurology16, National Institutes of Health17, Emory University18, San Francisco VA Medical Center19, University of California, San Francisco20, Veterans Health Administration21, Erasmus University Medical Center22, Baylor College of Medicine23, University of Kiel24, Hebrew University of Jerusalem25, University of Barcelona26, Columbia University Medical Center27, McGill University28, University of Alabama at Birmingham29, Northwestern University30, Icahn School of Medicine at Mount Sinai31, University of Perugia32, University of British Columbia33, Vancouver Coastal Health34
TL;DR: This multiple‐author article provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.
Abstract: This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple-author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state-of-the-art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society.
523 citations
Authors
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Name | H-index | Papers | Citations |
---|---|---|---|
Jose A. Obeso | 97 | 485 | 37597 |
Manuel Hidalgo | 92 | 538 | 41330 |
Alejandro Cifuentes | 66 | 369 | 16101 |
Manuel Talon | 66 | 175 | 22751 |
Manuel Ferrer | 64 | 230 | 11619 |
Philippe Valet | 63 | 276 | 13474 |
Coral Barbas | 58 | 299 | 11230 |
José M. Pingarrón | 56 | 456 | 14523 |
Domingo Barber | 48 | 194 | 7247 |
Mario Masellis | 42 | 212 | 6662 |
Michele Dileone | 42 | 102 | 6246 |
Carlos Oscar S. Sorzano | 41 | 221 | 7281 |
Manoj K. Karmakar | 40 | 154 | 5406 |
Jesús Almendral | 40 | 181 | 5472 |
Juan Rodríguez-Carvajal | 38 | 277 | 17793 |